A5101723345- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Genetics, Bioinformatics, and Biomedical Research
- HER2/EGFR in Cancer Research
- Genomic variations and chromosomal abnormalities
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- AI in cancer detection
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Cytokine Signaling Pathways and Interactions
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer and Skin Lesions
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
First Affiliated Hospital of Bengbu Medical College
2025
China Medical University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
National Clinical Research
2019-2023
Peking Union Medical College Hospital
2014-2022
Cancer Hospital of Chinese Academy of Medical Sciences
2020
Sentinel lymph node (LN) biopsy is currently the standard procedure for clinical LN‐negative breast cancer (BC) patients but it prone to false‐negative results and complications. Thus, an accurate noninvasive approach LN staging urgently needed in practice. Here, circulating exosomal microRNA (miRNA) expression profiles peripheral blood from BC age‐matched healthy women were obtained analyzed. We identified miRNA, miR‐363‐5p , that was significantly downregulated exosomes plasma of with...
Abstract Well-described evidence has demonstrated the critical roles of aerobic glycolysis in triple-negative breast cancer (TNBC) oncotherapy. Moreover, next-generation high-throughput sequencing indicates potential regulation energy metabolism by circular RNAs (circRNAs) TNBC. However, circRNA modulation TNBC is still unclear. Here, present research aimed to investigate function and underlying mechanisms novel circPDCD11 (hsa_circ_0019853) glycolysis. The results revealed that expression...
Cell cycle-associated proteins play important roles in breast cancer (BRCA), based on evidence from cell lines, preclinical murine models, and human tissue samples.Herein, we used the Onomine, GEPIA, Kaplan-Meier Plotter, cBioPortal databases to examine transcriptional survival data pertaining cyclin-associated gene clusters (CDK1, CCNA2, CCNB1) BRCA patients.CDK1, CCNB1 expression levels were higher compared with control samples correlated more-advanced tumor stage. analyses confirmed that...
Abstract Introduction. Although obesity has been reported worldwide as a risk factor for breast cancer, there are still some inconsistencies regarding the association between and cancer. Body mass index (BMI) is used most to assess extent of obesity; however, other body size characteristics, such waist hip circumference, with susceptibility cancer in Chinese Han women needs be better assessed. Patients Methods. Female patients (N = 2,800) were recruited from 21 hospitals northern eastern...
Background: Trastuzumab is an effective drug for the treatment of Her2-positive breast cancer. But, primary or secondary resistances to trastuzumab have become important factor influencing curative effect. The mechanisms resistance are somewhat complex. present work aims explore mechanism caused by HER-2 mutation in carcinomas. Methods: Firstly, HER2 wild type (WT) and mutant (HER2 Q429R, Q429H T798M commonest 3 types mutations) MCF7 cell lines were established. Cell proliferation inhibition...
The study is aimed at exploring the effect of microribonucleic acid- (miR-) 210 on chemosensitivity breast cancer and its potential molecular mechanism. Cell Counting Kit-8 (CCK-8) was applied to detect half maximal inhibitory concentration (IC50) cisplatin (DDP) cell, quantitative polymerase chain reaction (qPCR) carried out measure relative expression level miR-210. IC50 value DDP cells detected via CCK-8 after downregulating miR-210 in MCF-7/DDP cells. Flow cytometry terminal...
Abstract Background Identifying breast cancer patients with DNA repair pathway-related germline pathogenic variants (GPVs) is important for effectively employing systemic treatment strategies and risk-reducing interventions. However, current criteria risk prediction models prioritizing genetic testing among do not meet the demands of clinical practice due to insufficient accuracy. Methods The study population comprised 3041 enrolled from seven hospitals between October 2017 11 August 2019,...
IDO/TDO/Kyn/AhR signaling plays a crucial role in regulating innate and adaptive immunity, targeting Ah receptor (AhR) inhibition can potentially redirect immune cells toward an antitumoral phenotype. Therefore, AhR is attractive drug target for novel small molecule cancer immunotherapies. In this study, natural products tanshinolic A–D (1–4), the first adducts composed of ortho-naphthoquinone-type tanshinone phenolic acid featuring unique 1,4-benzodioxan hemiacetal structure, were isolated...
Background Breast cancer (BC) is one of the females’ most common malignant tumors there are large individual differences in its prognosis. We intended to uncover novel useful genetic biomarkers and a risk signature for BC aid determining clinical strategies. Methods A combined significance ( p ) was calculated each gene by Fisher’s method based on RNA-seq, CNV, DNA methylation data from TCGA-BRCA. Genes with < 0.01 were subjected univariate cox Lasso regression, whereby an RS...
To explore the effects of ulinastatin on proliferation and apoptosis breast cancer cells relevant mechanism action.
Background: Breast cancer patients with synchronous ipsilateral supraclavicular lymph node metastases (ISLNM) have unfavorable prognoses. The role of dissection (SLND) as a surgical intervention in the treatment this condition remains controversial. In study, we aimed to evaluate prognostic factors associated breast ISLNM and assess potential impact aggressive locoregional management on patient outcomes. Methods: We conducted retrospective analysis 250 who were treated curative intent at our...