A5078727917- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Breast Implant and Reconstruction
- Cancer, Stress, Anesthesia, and Immune Response
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Pancreatic and Hepatic Oncology Research
- Pituitary Gland Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Cancer, Lipids, and Metabolism
- Neuroscience and Neural Engineering
- Cancer Genomics and Diagnostics
- Cancer-related cognitive impairment studies
- Meningioma and schwannoma management
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Inner Mongolia University
2024-2025
Cancer Hospital of Chinese Academy of Medical Sciences
2025
Beijing Anzhen Hospital
2025
Capital Medical University
2025
National Clinical Research Center for Digestive Diseases
2021-2025
Qingdao University
2021-2024
Union Hospital
2024
Jilin University
2017-2024
Nanjing Agricultural University
2023-2024
Objective This study aimed to assess the efficacy and safety of camrelizumab plus apatinib in patients with resectable hepatocellular carcinoma (HCC) as neoadjuvant therapy. Methods Initially, 20 HCC were screened 18 enrolled this open-label, single-arm, phase II clinical trial. Patients received three cycles therapy including doses concurrent for 21 days followed by surgery. Four 8 weeks after surgery, eight adjuvant combination apatinib. Major pathological reactions (MPR), complete (pCR),...
Many neurological diseases involve neuroinflammation, during which overproduction of cytokines by immune cells, especially microglia, can aggregate neuronal death. Ferroptosis is a recently discovered cell metabolism-related form death and RSL3 well-known inducer ferroptosis. Here, we aimed to investigate the effects in neuroinflammation sensitivity different type microglia macrophage ferroptosis.Here, used quantitative RT-PCR analysis ELISA analyze production proinflammatory cytokine...
Abstract Background Postoperative cognitive dysfunction (POCD) is a common neurological complication of anesthesia and surgery in aging individuals. Neuroinflammation has been identified as hallmark POCD. However, safe effective treatments POCD are still lacking. Itaconate an immunoregulatory metabolite derived from the tricarboxylic acid cycle that exerts anti-inflammatory effects by activating nuclear factor erythroid 2-related 2 (Nrf2) pathway. In this study, we investigated underlying...
BackgroundAutomatic early detection of acromegaly is theoretically possible from facial photographs, which can lessen the prevalence and increase cure probability.MethodsIn this study, several popular machine learning algorithms were used to train a retrospective development dataset consisting 527 patients 596 normal subjects. We firstly OpenCV detect face bounding rectangle box, then cropped resized it same pixel dimensions. From detected faces, locations landmarks potential clinical...
Prognostic nutritional index (PNI), calculated as serum albumin (ALB) (g/L) + 5 × total lymphocyte count (109/L), is initially used to evaluate status in patients undergoing surgery and may the therapeutic effects predict survival of various solid tumors. The present study aimed potential prognostic significance PNI breast cancer receiving neoadjuvant chemotherapy (NACT).A 785 treated with were enrolled this retrospective study. optimal cutoff value by receiver operating characteristic curve...
<h3>Importance</h3> Breast cancer is the most commonly diagnosed and leading cause of death in women worldwide. Yet racial/ethnic disparity incidences distributions breast remains largely unknown. <h3>Objective</h3> To examine patterns associated with incidence subtypes distribution patients across clinicopathological variables. <h3>Design, Setting, Participants</h3> This population-based cohort study analyzed data from Surveillance, Epidemiology, End Results (SEER) database, which collected...
The systemic immune-inflammation index (SII = N × P/L) based on neutrophil (N), platelet (P) and lymphocyte (L) counts is used to predict the survival of patients with malignant tumours can fully reflect balance between host inflammatory immune status. This study conducted explore potential prognostic significance SII in breast cancer undergoing neoadjuvant chemotherapy (NACT). A total 262 received NACT were enrolled this study. According receiver operating characteristic curve, optimal...
Abstract Previously, several protein-coding tumor suppressors localized at 1p36 have been reported. In the present work, we focus on functional long non-coding RNAs (lncRNAs) embedded in this locus. Small interfering RNA was used to identify lncRNA candidates with growth-suppressive activities breast cancer. The mechanism involved also explored. LINC01355 were downregulated cancer cells relative non-malignant epithelial cells. Overexpression of significantly inhibited proliferation, colony...
Systemic inflammation response index (SIRI=N×M/L), based on neutrophil (N), monocyte (M), and lymphocyte (L) counts, is used to predict the survival of patients with malignant tumors can fully evaluate balance between host immune inflammatory condition. The present study aimed potential prognostic significance SIRI in breast cancer undergoing neoadjuvant chemotherapy.A total 262 treated chemotherapy were enrolled this retrospective study. optimal cutoff value by receiver operating...
Despite the development of various therapeutic modalities to tackle cancer, multidrug resistance (MDR) and incomplete destruction deep tissue-buried tumors remain as long-standing challenges responsible for tumor recurrence low survival rates. In addition MDR tissue photoactivation problems, most primary metastasize lungs lymph nodes form secondary tumors. Therefore, it leaves a great challenge develop theranostic approaches combat both problems. Herein, we versatile plasmonic CuO/Cu2O...
There is a close relationship between inflammatory cells and tumors, but the pathways that connect two remain unclear. This research explores clinical prognostic value of systemic inflammation response index (SIRI) in breast cancer patients. The study included 477 patients who underwent neoadjuvant chemotherapy 308 did not our center January 1998 December 2016. Optimal SIRI threshold values were determined using receiver operating characteristic curve (ROC). Patients then reclassified as...
MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated EC tissue and highly expressed estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression functions as via the miR-30c-MTA-1 signalling pathway. Furthermore, decreased upon E2 treatment both ER-positive Ishikawa ER-negative Taken together, our results suggest an important deregulated miRNA might serve potential biomarker...