A5031453154- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Valve Diseases and Treatments
- Advanced Image and Video Retrieval Techniques
- Multimodal Machine Learning Applications
- Neurological Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune cells in cancer
- Cardiovascular Issues in Pregnancy
- Domain Adaptation and Few-Shot Learning
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Dermatology and Skin Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Nuclear Receptors and Signaling
- Inflammation biomarkers and pathways
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Vascular Malformations Diagnosis and Treatment
Guangdong Academy of Medical Sciences
2024-2025
Southern Medical University
2024-2025
Guangdong Provincial People's Hospital
2024-2025
Affiliated Hospital of Qingdao University
2020-2025
Qingdao University
2020-2025
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Shengli Oilfield Central Hospital
2019-2024
Fudan University
2020-2023
Rutgers, The State University of New Jersey
2022
Many neurological diseases involve neuroinflammation, during which overproduction of cytokines by immune cells, especially microglia, can aggregate neuronal death. Ferroptosis is a recently discovered cell metabolism-related form death and RSL3 well-known inducer ferroptosis. Here, we aimed to investigate the effects in neuroinflammation sensitivity different type microglia macrophage ferroptosis.Here, used quantitative RT-PCR analysis ELISA analyze production proinflammatory cytokine...
Importance Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion the internal carotid artery (ICA) or middle cerebral (MCA), but there have been subsequent improvements surgical techniques and patient selection. Objective To evaluate EC-IC symptomatic ICA MCA, using refined operator Design, Setting, Participants This was a randomized, open-label, outcome assessor–blinded trial conducted at 13...
Abstract YTH Domain Containing 1 (YTHDC1) is one of the m 6 A readers that essential for oocyte development and tumor progression. The role YTHDC1 in neuronal survival ischemic stroke unknown. Here, we found was unregulated early phase stroke. Knockdown exacerbated brain injury overexpression protected rats against injury. Mechanistically, promoted PTEN mRNA degradation to increase Akt phosphorylation, thus facilitating particular after ischemia. These data identify as a novel regulator...
Zero-Shot Sketch-based Image Retrieval (ZS-SBIR) has been proposed recently, putting the traditional (SBIR) under setting of zero-shot learning. Dealing with both challenges in SBIR and learning makes it become a more difficult task. Previous works mainly focus on utilizing one kind information, i.e., visual information or semantic information. In this paper, we propose SketchGCN model graph convolution network, which simultaneously considers Thus, our can effectively narrow domain gap...
Abstract Background Although stent-assisted coiling has become a standard approach for treating intracranial aneurysms (IAs), there are limited reports on its safety and effectiveness in parent artery less than 2.5 mm diameter. This study evaluates the feasibility, safety, short-term outcomes of using Neuroform Atlas IAs with small vessels. Methods reviewed analyzed clinical data 50 patients diameter ≤ mm, treated at single center between November 2020 April 2024. Immediate postoperative...
This study investigates the molecular mechanisms and hub genes in idiopathic rupture of mitral valve chordae tendineae (iRCT). Histological changes were assessed via pathological staining, transcriptome sequencing was performed on samples from 8 iRCT patients 6 controls. Differentially expressed (DEGs), functional enrichment, PPI networks, immune cell infiltration analyzed. Hub gene expression validated using RT-qPCR. exhibited proliferation, disorganized collagen fibers, elastin fiber...
Dural arteriovenous fistulas (DAVFs) are associated with venous hypertension. Numerous studies have revealed high expression levels of vascular endothelial growth factor (VEGF) in human DAVF specimens, as well animal models experimental The objective the present study was to clarify whether VEGF signaling pathway is important development DAVFs. Rats (n=216) were randomly divided into six groups. In rats from five groups (groups A and C-E, n=45 each group; group B, n=12), hypertension induced...
This preclinical study in a porcine model of recurrent regurgitation following tricuspid valvuloplasty aims to confirm the feasibility and safety novel transjugular valve (TV) replacement device optimize implantation procedure prior first-in-human study. The was implanted via approach large white pig (n = 2). No perivalvular leakage (PVL) or central (TR) observed on post-operative echocardiography. mean transvalvular gradient at 3 months follow-up 1.69 ± 0.7 mmHg with mild TR but no PVL....
Immune response imbalance and cardiac dysfunction caused by sepsis are the main reasons for death in sepsis. This study aimed to confirm expression diagnostic possibility of microRNA-381-3p (miR-381-3p) its mechanism Quantitative real-time PCR (qRT-PCR) receiver operating characteristic (ROC) were used reveal levels clinical significance miR-381-3p. Pearson correlation was conducted provide correlations between miR-381-3p several indexes The H9c2 cell models constructed lipopolysaccharide...
Abstract Aim To study the effect of pharmacological inhibition epidermal growth factor receptor (EGFR) on intracranial aneurysm (IA) initiation. Methods Human IA samples were analyzed for expression p‐EGFR and alpha smooth muscle actin (α‐SMA) by immunofluorescence (IF). Rat models established to evaluate ability EGFR inhibitor, erlotinib, attenuate incidence IA. We anterior cerebral artery tissues pathological proteomic detection relevant proteins, vessel casting was used aneurysms in each...
Abstract A highly sensitive, specific and simple LC–MS/MS method for quantification of capmatinib (INC280) in rat plasma was presented. The validated terms specificity selectivity, linearity, accuracy precision, matrix effect, extraction recovery, dilution integrity, carryover stability as per the US Food Drug Administration's bioanalytical validation guideline. assay applied from a pharmacokinetic study rats following oral administration at doses 1.0, 3.0 9.0 mg/kg. calibration curve ranges...
Allergic asthma (AA) is closely associated with the polarization of T helper (Th)2 and Th17 cells. Interleukin (IL)-18 acts as an inducer Th2 cell responses. However, expressions IL-18 receptor alpha (IL-18Rα) in blood cells patients AA remain unclear. We therefore investigated their using flow cytometric analysis, quantitative real-time PCR (qPCR), murine model. observed increased proportions Th2, Th17, IL-18+, IL-18+ CD4+ AA. Additionally, house dust mite seemed to upregulate further...
Background: Leaflet augmentation is often required to correct an inadequate leaflet size due thickening, contracture and junctional fusion in patients with tricuspid valve regurgitation (TR) after left-side surgery (LSVS). However, the ideal material for remains controversial. This article aims compare medium- long-term results of repair bovine pericardium (BP) expanded Polytetrafluoroethylene (ePTFE) patches leaflets durability two materials. Methods: From January 2015 April 2023, a total...
Pancreatic cancer portal hypertension (PCPH) is a rare cause of gastrointestinal bleeding. This study retrospectively assessed bleeding risk factors in 57 PCPH patients diagnosed via multidetector computed tomography (MDCT).The data with pancreatic from January 2008 to 2018 at Qingdao Municipal Hospital were reviewed. screened MDCT and followed up. findings (e.g., the location venous obstruction, type variceal veins pathway, splenomegaly) recorded. Variceal hemorrhage was The clinical used...
Graph convolution networks (GCNs) have been widely used in the field of skeleton-based human action recognition. However, it is still difficult to improve recognition performance and reduce parameter complexity. In this paper, a novel multi-scale attention spatiotemporal GCN (MSA-STGCN) proposed for violence by learning features from four different skeleton modality variants. Firstly, original joint data are preprocessed obtain position, bone vector, motion datas as inputs framework. Then,...