A5100631091- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Wound Healing and Treatments
- Neuroscience and Neuropharmacology Research
- Forensic Entomology and Diptera Studies
- Muscle Physiology and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Insect Resistance and Genetics
- Diabetic Foot Ulcer Assessment and Management
- Alcohol Consumption and Health Effects
- Neurological Disease Mechanisms and Treatments
- Burn Injury Management and Outcomes
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Nicotinic Acetylcholine Receptors Study
- Glutathione Transferases and Polymorphisms
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Plant Stress Responses and Tolerance
- Forensic Toxicology and Drug Analysis
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
China Medical University
2016-2025
Liaoning University
2022-2025
Affiliated Hospital of Qingdao University
2017-2024
Kunming University of Science and Technology
2024
Harbin Medical University
2023-2024
Zhongshan Hospital
2024
State Key Laboratory of Medical Neurobiology
2024
University of Shanghai for Science and Technology
2023-2024
China Agricultural University
2003-2024
Qingdao University
2017-2024
Many neurological diseases involve neuroinflammation, during which overproduction of cytokines by immune cells, especially microglia, can aggregate neuronal death. Ferroptosis is a recently discovered cell metabolism-related form death and RSL3 well-known inducer ferroptosis. Here, we aimed to investigate the effects in neuroinflammation sensitivity different type microglia macrophage ferroptosis.Here, used quantitative RT-PCR analysis ELISA analyze production proinflammatory cytokine...
Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI) outcomes. NRF2 is the predominant transcription factor regulating oxidative stress neuroinflammation in TBI, but its role iron-induced post-TBI damage unclear. We investigated ferroptotic neuronal injured cortex observed neurological deficits post-TBI. These were ameliorated by iron chelator deferoxamine (DFO) wild-type mice. In Nrf2-knockout (Nrf2-/-) mice, more sever ferroptosis detected. Dimethyl fumarate...
Wound healing represents a well orchestrated reparative response that is induced by injuries. Angiogenesis plays central role in wound healing. In this work, we sought to develop the first mathematical model directed at addressing of tissue oxygen tension on cutaneous Key components developed include capillary tips, sprouts, fibroblasts, inflammatory cells, chemoattractants, oxygen, and extracellular matrix. The consists system nonlinear partial differential equations describing interactions...
Non-alcoholic fatty liver disease (NAFLD) is an emerging global with increasing prevalence. However, the mechanism of NAFLD development not fully understood. To elucidate cell-specific role nuclear factor erythroid-derived 2-like 2 (NRF2) in pathogenesis NAFLD, we utilized hepatocyte- and macrophage-specific Nrf2-knockout [Nrf2(L)-KO Nrf2(Mϕ)-KO] mice to examine progress induced by high-fat diet (HFD). Compared Nrf2-LoxP littermates, Nrf2(L)-KO showed less enlargement, milder inflammation...
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by accumulation of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Accumulating evidence has revealed that slow progressive deterioration AD associated with oxidative stress chronic inflammation in brain. Nuclear factor erythroid 2- (NF-E2-) related 2 (Nrf2), which acts through Nrf2/ARE pathway, a key regulator antioxidant anti-inflammatory response. Although recent data show link between Nrf2...
Human exposure to inorganic arsenic leads various dermal disorders, including hyperkeratosis and skin cancer. Curcumin is demonstrated induce remarkable antioxidant activity in a variety of cells tissues. The present study aimed at identifying curcumin as potent activator nuclear factor erythroid 2-related 2 (NRF2) demonstrating its protective effect against arsenite- (iAs 3+ -) induced cytotoxicity human keratinocytes. We found that led accumulation NRF2 protein increased the expression...
Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function induce psychotic states. Neuroinflammation has been suggested to play important role in neurodegeneration. Meanwhile, modulate the levels inflammatory cytokines. We hypothesized effects on central nervous system are associated with Therefore, we set out establish acute chronic administration models C57BL/6 mice, evaluate...
Resistance to chemotherapy is a major obstacle in the treatment of human hepatocellular carcinoma (HCC). Despite playing an important role chemoprevention, nuclear factor erythroid 2-related 2 (NRF2) also contributes chemo- and radio-resistance. The current study focusses on camptothecin as novel NRF2 inhibitor sensitise HCC chemotherapy. expression transcriptional activity biopsies camptothecin-treated culture cells were determined using immunostaining, western blot, reverse-transcription...
BackgroundHuman exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor–erythroid 2–related factor 1 (NRF1, also called NFE2L1) plays critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes.ObjectivesWe investigated NRF1 arsenic-induced cytotoxicity human keratinocytes.ResultsIn cultured keratinocyte HaCaT cells, arsenite (iAs3+) enhanced protein...
Nuclear factor E2-related factors (NRFs), including NRF2 and NRF1, play critical roles in mediating the cellular adaptive response to oxidative stress. Human exposure inorganic arsenic, a potent stressor, causes various dermal disorders, hyperkeratosis skin cancer.
Chronic exposure to arsenic induces a variety of cancers, particularly in the skin. Autophagy is highly conserved process which plays dual role tumorigenesis. In present study, we found that chronic an environmentally relevant dose arsenite induced malignant transformation human keratinocytes (HaCaT) with dysregulated autophagy as indicated by increased number autophagosomes, activation mTORC1 pathway, and elevated protein levels p62 LC3II. Meanwhile, arsenite-transformed cells showed lower...
Excessive iron released by hemoglobin and necrotic tissues is the predominant factor that aggravates outcome of traumatic brain injury (TBI). Regulating levels its metabolism a feasible way to alleviate damage due TBI. However, spatial-temporal deposition in neurons glial cells after TBI remains unclear. In our study, male C57BL/6 mice (8-12 weeks old, weighing 20-26 g) were conducted using controlled cortical impact (CCI) models, combined with treatment chelator deferoxamine (DFO), followed...