A5086868831- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Fire effects on ecosystems
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Liver Diseases and Immunity
- Muscle and Compartmental Disorders
- Liver Disease and Transplantation
- Respiratory viral infections research
- Pediatric Hepatobiliary Diseases and Treatments
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Hepatocellular Carcinoma Treatment and Prognosis
- Arsenic contamination and mitigation
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Connexins and lens biology
- Animal Virus Infections Studies
- Hematological disorders and diagnostics
- Abdominal Surgery and Complications
- Pneumonia and Respiratory Infections
- Drug-Induced Hepatotoxicity and Protection
First Hospital of China Medical University
2010-2025
China Medical University
2012-2025
302 Military Hospital of China
2012
Shiraz University of Medical Sciences
2012
University of California Davis Medical Center
2012
BackgroundIn 2009, severe fever with thrombocytopenia syndrome virus (SFTSV) was identified as a novel member of the genus phlebovirus in Bunyaviridae family China. The detailed clinical features cases SFTSV infection have not been well described, and risk factors for severity among patients fatality remain to be determined. Methodology/Principal FindingsClinical laboratory 115 hospitalized during period from June 2010 December 2011 Northeast China were retrospectively reviewed. We assessed...
Severe fever with thrombocytopenia syndrome virus (SFTSV), which can cause hemorrhagic fever-like illness, is a newly discovered bunyavirus in China. The pathogenesis of SFTSV infection poorly understood. However, it has been suggested that immune mechanisms, including cytokines and chemokines, play an important role disease pathogenesis. In the present study, we investigated host cytokine chemokine profiles serum samples patients from Northeast China explored possible correlation between...
Lopinavir/ritonavir, an anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug, may be associated with the development of liver injury. In this paper, we reported elderly female patient drug-induced injury secondary to lopinavir/ritonavir, which was evaluated for their causality using updated Roussel Uclaf Causality Assessment Method (RUCAM) 2016. She had a RUCAM score 8 equivalent probable grading. Her clinical course complicated by persistent hepatocyte secretion failure...
Abstract Background During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. We describe clinical characteristics factors associated with death patients who were hospitalized 2009 H1N1 pneumonia in Shenyang, China, from November to December 2009. Methods carried out retrospective chart review 68 confirmed have infection by real time RT-PCR assay respiratory specimens. Results Of we studied, 30 (44%) admitted an intensive care unit 10 (14.7%) died. The...
Human exposure to inorganic arsenic leads various dermal disorders, including hyperkeratosis and skin cancer. Curcumin is demonstrated induce remarkable antioxidant activity in a variety of cells tissues. The present study aimed at identifying curcumin as potent activator nuclear factor erythroid 2-related 2 (NRF2) demonstrating its protective effect against arsenite- (iAs 3+ -) induced cytotoxicity human keratinocytes. We found that led accumulation NRF2 protein increased the expression...
Hepatocellular carcinoma remains one of the leading contributors to global cancer mortality, frequently stemming from chronic liver conditions, such as viral hepatitis, non-alcoholic fatty disease, and alcohol-induced cirrhosis. While antiviral treatments have made significant strides, rising prevalence hepatocellular linked non-infectious causes underscores pressing demand for more effective diagnostic tools therapeutic interventions. Advances in imaging liquid biopsy technologies...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease recently discovered in northeastern and central China that caused by a novel bunyavirus, severe virus (SFTSV). Humans are primarily infected through tick bites. Four previous reports have discussed SFTS infection from person to person, all cases of which were symptomatic. In this report, we analysed the epidemiological clinical data for cluster cases, including one case secondary-asymptomatic infection,...
Myopia is a major public health concern with increasing global prevalence and the leading cause of vision loss complications. The potential role cornea, substantial component refractive power protective fortress eye, has been underestimated in development myopia. Our study acquired corneal stroma tissues from myopic patients undergoing femtosecond laser-assisted small incision lenticule extraction (SMILE) surgery investigated differential expression circulating proteins between subjects low...
Although hepatitis B virus (HBV) primarily affects hepatocytes, it has also been shown to cause complications in the skin, joints, muscles, and kidneys. Thyroid dysfunction is uncommon cases of acute HBV infection. In this report, we describe a case 46-year-old woman with incipient infection who presented clinically Graves' hyperthyroidism. She showed typical symptoms hyperthyroidism, laboratory tests revealed high levels DNA alanine transaminase (ALT). The patient was not administered...
Abstract Background We report a mononucleosis-like illnesses case due to co-infection with severe fever thrombocytopenia syndrome virus (SFTSV) and spotted group rickettsia (SFGR), which the best of our knowledge, has never been reported . Case presentation A 64-year-old male an 11-day history fever, sore throat, malaise, nausea, non-pruritic rash was admitted emergency department. Prior admission, he bitten by ticks. Laboratory tests revealed white blood cell count 24,460 cells/μL 25%...
Progressive familial intrahepatic cholestasis type 1 is a rare disease that characterized by low serum γ-glutamyltransferase levels due to mutation in ATP8B1 .We present 23-year-old male who experienced persistent marked pruritus for eighteen years and recurrent jaundice thirteen years, addition eventually became fatal.Genetic sequencing studies of the entire coding (exon) sequences ABCB11 uncovered novel heterozygous missense 3035G>T (S1012I) synonymous 696T>C .The patient's progression was...
Abstract Background Vanishing bile duct syndrome (VBDS) is a rare but potentially severe acquired chronic cholestatic liver disease. Bile deficiency reduction of ducts in the liver, which can eventually lead to disease and progress biliary cirrhosis. Primary cholangitis (PBC) one causes deficiency. In addition, 75% PBC patients may have dyslipidemia, case secondary cutaneous xanthomas occur. Case summary A 49-year-old woman was admitted with jaundice multiple subcutaneous nodules. She...
To analyze and discuss the transmission route of a cluster cases severe fever with thrombocytopenia syndrome bunyavirus (SFTSV).We performed an epidemiological investigation genetic analysis patients (SFTS) caused by SFTSV, their close contacts surrounding population.We found that all had contact blood first patient. The comparison gene sequences in three isolated SFTSV strains showed were closely related. Six nine individuals population positive for IgM antibody.We suspect outbreak was...
Hepatitis E virus (HEV) infection is a global health concern, with large number of new infections reported every year. In developing countries poor sanitation condition, HEV1 and HEV2 are mainly transmitted by the fecal-oral route due to water contamination. HEV3 HEV4 zoonotic diseases in humans consuming undercooked pork, developed countries. Usually, HEV an acute self-limited course, chronic can occur immunocompromised individuals. The diagnosis relies on sero - logical tests, including...