A5100739398- Renal and related cancers
- RNA modifications and cancer
- Clinical Laboratory Practices and Quality Control
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Telomeres, Telomerase, and Senescence
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Pluripotent Stem Cells Research
- Meta-analysis and systematic reviews
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Wuxi Ninth People's Hospital
2024
Soochow University
2023-2024
First Affiliated Hospital of Soochow University
2023-2024
Shanxi Medical University
2023-2024
Hebei Medical University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Peking Union Medical College Hospital
2008-2023
Nankai University
2023
Weatherford College
2023
Objective To profile gut microbiome-associated metabolites in serum and investigate whether these could distinguish individuals with colorectal cancer (CRC) or adenoma from normal healthy individuals. Design Integrated analysis of untargeted metabolomics by liquid chromatography-mass spectrometry metagenome sequencing paired faecal samples was applied to identify significantly altered abundance patients CRC adenoma. The ability discriminate between tested targeted metabolomic analysis. A...
To improve the identification for CTCs with weak or negative CK and diploid in pancreatic cancer, we combined immune‐staining of CK, CD45, DAPI fluorescence situ hybridization centromere chromosome 8 (CEP8) probe method. 3.75 mL blood were depleted CD45 positive cells anti‐CD45 antibodies identified by combining CEP8 61 cases including 22 cancers, 3 borderline solid pseudopapillary tumors, 6 benign 30 healthy individuals. We found that enriched could be classified into 5 patterns:...
Objective— Homocysteine can accelerate the senescence of endothelial progenitor cells or (ECs) via telomerase inactivation and length shortening. However, underlying mechanism is unclear. Here, we investigated whether homocysteine promotes by reducing expression activity human reverse transcriptase (hTERT) DNA methylation to reduce ECs activity. Approach Results— When compared with primary umbilical vein grown under standard conditions, chronic treatment showed accelerated upregulation p16,...
Abstract miRNAs have been established as critical layer of regulation during tumorigenesis; extracellular are extraordinarily stable; and, quantitative reverse transcript polymerase chain reaction (qRT-PCR) provides a sensitive platform for quantifying with broad dynamic range. Herein, we aimed to establish serum miRNA signature diagnosing cervical cancer (CC). In this study, recruited cohort 184 CC, 186 intraepithelial neoplasia (CIN) patients and 193 healthy control subjects. qRT-PCR was...
FUN14 domain-containing 1 (FUNDC1), as a novel member of mitochondria-associated endoplasmic reticulum (ER) membranes associates with mitochondrial division and mitophagy. However, the expression profile functional roles FUNDC1 remain largely unclear in human cancer biology, including breast (BC).Immunohistochemistry western blot analysis were used to determine BMI1 polycomb ring finger oncogene (BMI1). CCK8, cell counting transwell assays analyze proliferation, migration invasion,...
Modification of the novel N6-methyladenine (m6A) DNA implicates this epigenetic mark in human malignant disease, but its role atherosclerosis (AS) is largely unknown. Here, we found that leukocyte level m6A not 5mC modification was decreased with increasing carotid plaque size and thickness 207 AS patients as compared 142 sex- age-matched controls. Serum low-density lipoprotein (LDL) levels were associated progression thickness. Both LDL also independently negatively related to level....
Our previous work shows that the stem cell factor SALL4 plays a central role in embryonic and leukemic cells. In this study, we report expression was higher drug resistant primary acute myeloid patients than those from drug-responsive cases. addition, while overexpression of led to resistance lines, cells with decreased were more sensitive treatments parental This our investigation implication its side population (SP) cancer SP compared non-SP by 2-4 fold various malignant hematopoietic...
Our aim in this study was to identify a prognostic biomarker predict the disease prognosis and reduce mortality rate of coronavirus 2019 (COVID-19), which has caused worldwide pandemic.COVID-19 patients were randomly divided into training test groups. Univariate multivariate Cox regression analyses performed signature, selected establish risk model group. The signature COVID-19 validated group.The combined with following 5 indicators: neutrophil count, lymphocyte procalcitonin, age,...
Cervical spondylosis (CS), including myelopathy and radiculopathy, is the most common degenerative cervical spine disease. This study aims to evaluate clinical outcomes of unilateral biportal endoscopy (UBE) compared those conventional anterior decompression fusion (ACDF) for treating radiculopathy or coexisting induced by herniated discs.
Background: Clinical management of lumbar infectious spondylodiscitis is challenging due to its variable presentation and complex course, treatment remains controversial. This study aims evaluate the clinical efficacy unilateral biportal endoscopic (UBE) debridement drainage for treating spondylodiscitis. Methods: We retrospectively analysed sixteen patients diagnosed with who underwent UBE between April 2022 July 2023. Biopsy specimens were sent laboratory identify pathogens immediately...
Background:Elevated homocysteine (Hcy) levels might play a role in the development of essential hypertension (EH). Telomere dynamics provide valuable insight into pathogenesis age-related diseases. The contribution Hcy to leukocyte telomere length (LTL) shortening EH and underlying mechanism was examined.Methods Results:LTL (ratio copy number [T] repeats that single [S] gene, T/S ratio) inversely associated with age patients (n=258) healthy controls (n=137), but significantly decreased level...
KRAS and TP53 mutations are the two most common driver in patients with lung adenocarcinoma (LUAD), they appear to reduce latency increase metastatic proclivity when a co-mutation (KRAS/TP53-mut) occurs. However, molecular mechanism involved is unclear. N6-methyladenosine (m6A), abundant RNA modification mammal mRNAs, plays critical role tumorigenesis. Here, we used genomic transcriptomic data found that only LUAD KRAS/TP53-mut, but not an individual mutation, appeared exhibit poor overall...
Abstract Pyroptosis, as a proinflammatory form of regulated cell death, plays an important role in multiple cancers. However, the diagnostic and prognostic values pyroptosis its interaction with tumor immunity pan-cancer are still unclear. Here, we show elevated general expression 17 pyroptosis-associated genes patients high-immune-activity reduced low-immune-activity tumors. Moreover, is positively correlated immune infiltration immune-related signatures across 30 types cancer. Furthermore,...
Abstract Background Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases with variable clinical course. Predicting disease progression is difficult due to lack specific molecular marker(s). SALL4 plays important roles in normal hematopoiesis and leukemogenesis. transgenic mice develop MDS prior acute myeloid leukemia (AML) transformation. However, the role human has not been extensively investigated. In this study, we evaluate diagnostic/prognostic value by examining its...
Abstract MiR-494 plays an important role in several types of human cancers, including non-small cell lung cancer (NSCLC). Although the miR-494 has been investigated studies, expression profile and underlying mechanism are still poorly understood. In this study, we found that overexpression promoted proliferation colony formation NSCLC cells reduced their sensitivity to cisplatin-induced apoptosis. By using microarray Dual luciferase reporter assays, further showed caspase-2 (CASP2) is a...