A5101577130- RNA modifications and cancer
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Sphingolipid Metabolism and Signaling
- HVDC Systems and Fault Protection
- Ginseng Biological Effects and Applications
- Viral-associated cancers and disorders
- Glycosylation and Glycoproteins Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Harbin Medical University
2015-2022
Third Affiliated Hospital of Harbin Medical University
2015-2022
Fourth Affiliated Hospital of Harbin Medical University
2015-2021
Breast cancer (BC) displays striking genetic, epigenetic and phenotypic diversity. N6-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls self-renewal cell fate. However, the key enzymes of m6A expression function human breast carcinogenesis remain unclear. The methylases (METTL3, METTL14 WTAP) demethylases (FTO ALKBH5) were analyzed by using ONCOMINE Cancer Genome Atlas databases 36 pairs BC adjacent non-cancerous tissue. level patients was...
Lung cancer is the major cause of cancer-related death worldwide, and 80 % them are non-small cell lung (NSCLC) cases. Recent studies have shown that sphingosine kinase 2 (SphK2) could promote tumor progression; however, whether SphK2 affect chemoresistance NSCLC to chemotherapy remains unclear. To determine serves as a potential therapeutic target NSCLC, we utilized small interference RNA (siRNA) knock down expression in human cells analyzed their phenotypic changes. The data demonstrated...
KRAS and TP53 mutations are the two most common driver in patients with lung adenocarcinoma (LUAD), they appear to reduce latency increase metastatic proclivity when a co-mutation (KRAS/TP53-mut) occurs. However, molecular mechanism involved is unclear. N6-methyladenosine (m6A), abundant RNA modification mammal mRNAs, plays critical role tumorigenesis. Here, we used genomic transcriptomic data found that only LUAD KRAS/TP53-mut, but not an individual mutation, appeared exhibit poor overall...
Abstract DNA N6-methyladenosine (6mA) is a novel epigenetic signaling modification in humans and has been implicated the progression tumorigenesis of several cancers. However, function mechanism 6mA breast cancer (BC), most common among women, are unclear. Here, we found that decreases N6AMT1 correlated with extent clinical BC tissues predicted worse survival patients. Functionally, knockdown markedly reduced promoted colony formation migration cells, whereas overexpression had opposite...
Aberrant epigenetic drivers or suppressors contribute to LUAD progression and drug resistance, including KRAS, PTEN, Keap1. Human Plant Homeodomain (PHD) finger protein 1 (PHF1) coordinates with H3K36me3 increase nucleosomal DNA accessibility. Previous studies revealed that PHF1 is markedly upregulated in various tumors enhances cell proliferation, migration tumorigenesis. However, its roles are still unknown. We aimed depict the biological of identify useful targets for clinical treatment...
Non-small cell lung cancer (NSCLC) is a devastating disease with heterogeneous prognosis, and the molecular mechanisms underlying tumor progression remain elusive. Mammalian Eps15 homology domain 1 (EHD1) plays promotive role in progression, but its angiogenesis remains unknown. This study thus explored of EHD1 NSCLC. The changes were evaluated through human umbilical vein endothelial (HUVEC) proliferation, migration tube formation assays. impact on β2-adrenoceptor (β2AR) signaling was by...
Abstract Background Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms required. Nonhuman primates, which share the closest genetic relationship with humans, serve as ideal model exploring complex aging process. However, potential nonhuman primate animal in screening human markers still not fully exploited. Multiomics analysis peripheral blood offers promising approach to evaluate new therapies and biomarkers. This...