A5052383386- Cardiac Valve Diseases and Treatments
- Cardiac Fibrosis and Remodeling
- Prostate Cancer Treatment and Research
- Signaling Pathways in Disease
- COVID-19 diagnosis using AI
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Cardiac electrophysiology and arrhythmias
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Infective Endocarditis Diagnosis and Management
- Advanced Glycation End Products research
- Cardiac pacing and defibrillation studies
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Advanced X-ray and CT Imaging
- Curcumin's Biomedical Applications
Wenzhou Medical University
2016-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2024
Zhejiang Institute of Communications
2022-2023
Breast cancer (BC) displays striking genetic, epigenetic and phenotypic diversity. N6-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls self-renewal cell fate. However, the key enzymes of m6A expression function human breast carcinogenesis remain unclear. The methylases (METTL3, METTL14 WTAP) demethylases (FTO ALKBH5) were analyzed by using ONCOMINE Cancer Genome Atlas databases 36 pairs BC adjacent non-cancerous tissue. level patients was...
BACKGROUND: Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates. MicroRNAs (miRs) are closely related to heart disease, among which miR-574-3p plays an important role in myocardial remodeling, but its exercise-mediated cardioprotection is still unclear. METHODS: A mouse hypertrophy model was established by transverse aortic coarctation, a 4-week swimming exercise performed 1 week after the operation. After...
The optimal strategy to treat coronary bifurcation lesions (CBL) has been a long-debated topic. combination of stent in the main vessel (MV) and drug-coated balloon (DCB) side branch (SB) seems promising, but evidence is limited. This study aims investigate novel sirolimus-coated treatment non-left CBL compared with paclitaxel-coated balloon. SPACIOUS trial prospective, non-inferiority, multicentre trial. A total 230 patients were randomised sirolimus DCB or paclitaxel group 1:1 ratio....
FUN14 domain-containing 1 (FUNDC1), as a novel member of mitochondria-associated endoplasmic reticulum (ER) membranes associates with mitochondrial division and mitophagy. However, the expression profile functional roles FUNDC1 remain largely unclear in human cancer biology, including breast (BC).Immunohistochemistry western blot analysis were used to determine BMI1 polycomb ring finger oncogene (BMI1). CCK8, cell counting transwell assays analyze proliferation, migration invasion,...
Modification of the novel N6-methyladenine (m6A) DNA implicates this epigenetic mark in human malignant disease, but its role atherosclerosis (AS) is largely unknown. Here, we found that leukocyte level m6A not 5mC modification was decreased with increasing carotid plaque size and thickness 207 AS patients as compared 142 sex- age-matched controls. Serum low-density lipoprotein (LDL) levels were associated progression thickness. Both LDL also independently negatively related to level....
Abstract Both N6-methyladenosine (m6A) RNA modification and microRNAs (miRNAs) are common regulatory mechanisms for gene post-transcription by modulating mRNA stability translation. They also share the same 3′-untranslated regions (UTRs) their target gene. However, little is known about potential interaction in cell development biology. Here, we aimed to investigate how m6A regulates specific miRNA repression during cardiac hypertrophy. Our multiple lines of bioinformatic molecular...
Obesity is strongly associated with the cause of structural and functional changes heart in both human animal models. Oxidative stress inflammation play a critical role development obesity-induced cardiac disorders. Curcumin natural product from Curcuma Longa multiple bioactivities. In our previous study, order to reach better anti-inflammatory anti-oxidant dual activities, we designed new mono-carbonyl curcumin analog, Y20, via modification trifluoromethyl bromine. This study was...
Although c-MYC and mTOR are frequently activated proteins in prostate cancer, any interaction between the two is largely untested. Here, we characterize functional cross-talk FOXP3-c-MYC TSC1-mTOR signaling during tumor progression. Deletion of Tsc1 mouse embryonic fibroblasts (MEF) decreased phosphorylation at threonine 58 (pT58) increased serine 62 (pS62), an observation validated cancer cells. Conversely, inhibition pT58 but pS62. Loss both FOXP3 TSC1 cells synergistically enhanced...
Myocardial infarction is one of the most serious fatal diseases in world, which due to acute occlusion coronary arteries. Grape seed proanthocyanidin extract (GSPE) an active compound extracted from grape seeds that has anti-oxidative, anti-inflammatory and anti-tumor pharmacological effects. Natural products are cheap, easy obtain, widely used effective. It been treat numerous diseases, such as cancer, brain injury diabetes complications. However, there limited studies on its role...
Abstract Transforming growth factor β‐activated protein kinase 1 (TAK1) involves in various biological responses and is a key regulator of cell death. However, the role TAK1 on acute myocardial ischaemia/reperfusion (MI/R) injury unknown. We observed that activation increased significantly after MI/R hypoxia/reoxygenation (H/R), we hypothesized has an important injury. Mice (TAK1 inhibiting by 5Z‐7‐oxozeaenol or silencing AAV9 vector) were exposed to Primary cardiomyocytes siRNA;...
The autonomic nervous system dysfunction with increased sympathetic activity and withdrawal of vagal may play an important role in the pathogenesis viral myocarditis. vagus nerve can modulate immune response control inflammation through a 'cholinergic anti-inflammatory pathway' dependent on α7-nicotinic acetylcholine receptor (α7nAChR). Although β-adrenergic stimulation myocarditis has been investigated our pervious studies, direct effect tone this setting not yet studied. Therefore, present...
Persistent myocardial ischemia post-myocardial infarction can lead to fatal ventricular arrhythmias such as tachycardia and fibrillation, both of which carry high mortality rates. Dexmedetomidine (Dex) is a highly selective α2-agonist used in surgery for congenital cardiac disease because its antiarrhythmic properties. Dex has previously been reported prevent or terminate various arrhythmias. The purpose the present study was determine anti-arrhythmic properties context ischemic...
Background Idiopathic premature ventricular contractions (PVCs) and tachycardias (IVTs) originating from the subtricuspid septum near His bundle have been reported. However, little is known about prevalence, distribution, electrocardiographic characteristics efficacy of radiofrequency catheter ablation (RFCA) for arrhythmias arising right (RV) septum. This study aimed to investigate effects RFCA patients with symptomatic PVCs/IVTs, different portions RV Methodology/Principal Findings...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in clinic, with characteristics occult onset, rapid progression, and high degree malignancy. Alpha fetoprotein (AFP) important biomarker HCC, which widely used early screening, diagnosis, prognosis observation. A series immunoassays have been developed frequently detection AFP based on antibodies. Unfortunately, shortcomings antibodies, such as thermal unstable fluctuant activity by batches, lead to inaccuracy AFP. In...
A20, a negative regulator of nuclear factor κB signaling, has been shown to attenuate atherosclerotic events. Transforming growth beta-activated kinase 1 (TAK1) plays critical role in TNFα-induced atherosclerosis via endothelial nitric oxide (NO) synthase (eNOS) uncoupling and NO reduction. In the study, we investigated hypothesis that A20 protected cell injury induced by TNFα through modulating eNOS activity TAK1 signalling. Human umbilical vein cells (HUVECs) were stimulated TNFα. The...
Acute morphological changes in de novo coronary lesions after drug-coated balloon (DCB) angioplasty can affect endothelial mechanics and consequently clinical outcomes. Angiography-based computational modeling has been validated to assess dynamic strain (EDS) arteries vivo. The EDS was calculated on the basis of pre- post-DCB angiography. Parameters quantitative angiography were quantified at cross-sections treated segments. A total 336 348 lesion included small/large vessel groups,...