A5035239238- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Traditional Chinese Medicine Analysis
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- Angiogenesis and VEGF in Cancer
- Cardiac Arrhythmias and Treatments
- Nitric Oxide and Endothelin Effects
- Vascular Anomalies and Treatments
- Congenital heart defects research
- Liver Disease Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Circular RNAs in diseases
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Bioactive Compounds and Antitumor Agents
- Acute Ischemic Stroke Management
- Galectins and Cancer Biology
- Nigella sativa pharmacological applications
- Intracerebral and Subarachnoid Hemorrhage Research
- TGF-β signaling in diseases
Zhejiang University
2006-2025
Lishui Central Hospital
2005-2023
Wenzhou Medical University
2015-2023
Lishui University
2020-2022
Charles Sturt University
2005-2006
Abstract SHP2 mediates the activities of multiple receptor tyrosine kinase signaling and its function in endothelial processes has been explored extensively. However, genetic studies on role tumor angiogenesis have not conducted. Here, we show that is activated endothelia. Shp2 deletion pharmacological inhibition reduce growth microvascular density mouse models. also leads to vascular normalization, indicated by increased pericyte coverage vessel perfusion. inefficiency impairs cell...
Recent studies have shown that resveratrol increased endothelial progenitor cells (EPCs) numbers and functional activity. However, the mechanisms remain to be determined. Previous demonstrated EPC activity were associated with inhibition of senescence, which involves activation telomerase. Therefore, we investigated whether inhibits onset senescence through telomerase activation, leading potentiation cellular activity.After prolonged in vitro cultivation, EPCs incubated or without...
Transforming growth factor β (TGFβ) signaling plays an important role in regulating tumor malignancy, including non–small cell lung cancer (NSCLC). The major biological responses of TGFβ are determined by the effector proteins SMAD2 and SMAD3. However, regulators TGFβ–SMAD not completely revealed yet. Here, we showed that scaffolding protein PDLIM5 (PDZ LIM domain 5, ENH) critically promotes maintaining SMAD3 stability NSCLC. First, was highly expressed NSCLC compared with adjacent normal...
Data are limited on the prevalence and vascular distribution of multiterritorial atherosclerotic plaque stenosis in community populations.To investigate older, community-dwelling populations China.This cross-sectional study was based baseline survey from Polyvascular Evaluation for Cognitive Impairment Vascular Events (PRECISE) study, a population-based prospective cohort that enrolled adults aged 50 to 75 years cluster sampling 6 villages 4 living communities Lishui city southeast China....
Background and purpose Cardiovascular diseases dementia are two major in the elderly. Atherosclerosis is associated with future vascular events cognitive impairment. The PolyvasculaR Evaluation for Cognitive Impairment vaScular Events (PRECISE) study a population-based prospective cohort comprehensive evaluation of multiterritorial artery stenosis plaque using advanced imaging techniques collection assessments. Methods Between May 2017 September 2019, PRECISE enrolled 3067 community-dwelling...
The aim of the present study was to investigate protective effect salvianolic acid A (SAA) on myocardial ischemia/reperfusion injury in rats. SAA (10 mg/kg) or Tirofiban (60 µg/kg) administered rats by jugular vein injection 10 min before initiation reperfusion. After 3 h reperfusion, platelet aggregation measured using an aggregometer and levels nitric oxide (NO) were detected ultraviolet spectrophotometer. Serum cardiac troponin T (cTnT), creatine kinase isoenzyme MB (CK-MB), p-selectin,...
Background: We aimed to evaluate the effects of both joint and individual types fatty acids on low muscle mass in adults. Methods: enrolled 8842 adults selected from National Health Nutrition Examination Survey (NHANES). Multivariate adjusted weighted logistic regression models were employed connection between mass. used restricted cubic splines (RCSs) determine whether relationship is linear or non-linear, while stratified analyses interaction also assessed. Weighted quantile sum (WQS)...
Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship limited in Japan. The purpose of study was to evaluate the correlation between TyG and risk T2DM Japanese population. Here, 12732 participants were selected from NAGALA (NAfld Gifu Area, Longitudinal Analysis) conducted 2004 2015 for a retrospective cohort analysis. association assessed using Cox proportional-hazard model. Subgroup analyses according age, sex, smoking...
Abstract The excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are mainly responsible for occlusion diseases, such as pulmonary arterial hypertension restenosis. Our previous study demonstrated thymoquinone (TQ) attenuated monocrotaline‐induced hypertension. aim the present is to systematically examine inhibitory effects TQ on platelet‐derived growth factor‐BB (PDGF‐BB)–induced VSMCs in vitro neointimal formation vivo elucidate potential mechanisms. Vascular were...
A decrease in nitric oxide, leading to vascular smooth muscle cell proliferation, is a common pathological feature of proliferative diseases. Nitric oxide synthesis by eNOS (endothelial synthase) precisely regulated protein kinases including AKT1. ENH (enigma homolog protein) scaffolding for multiple kinases, but whether it regulates activation and remodeling remains unknown. Approach Results: was upregulated injured mouse arteries human atherosclerotic plaques associated with coronary...
Pulmonary arterial hypertension (PAH) is a life‑threatening disease induced by the excessive proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Formononetin (FMN) natural isoflavone with numerous cardioprotective properties, which can inhibit induce tumor cells; however, whether FMN has therapeutic effect on PAH remains unclear. In present study, was in rats monocrotaline (MCT, 60 mg/kg); were then administered (10, 30 or mg/kg/day). At end experiment,...
The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, objective this study was to investigate BUN hospital mortality in critically ill patients with cardiogenic shock (CS). This a retrospective cohort study, which data were obtained from Medical Information Mart for Intensive Care III V1.4 database. Data 697 CS analyzed. Logistic regression subgroup analyses used assess CS. average age participants 71.14 years, approximately 42.18%...
Objective: Cerebral microbleeds (CMBs), which appear as small dot-like hypointense lesions, are strongly associated with cerebrovascular disease. Recently, numerous investigations have suggested that hypertension and age risk factors for CMBs; however, whether blood pressure grade rank related to the severity of CMBs remains unclear. The purpose this research was assess association between cerebral levels.Methods: In total, 460 consecutive patients (214 males 246 females; aged 44-96 years,...
Pulmonary arterial hypertension (PAH) caused by enhanced pressure increases vessel resistance in the lung. Endothelial-to-mesenchymal transition (EndMT) plays key roles vascular remodeling PAH. Naringin, a protective gaseous mediator is commonly extracted from tomatoes and citrus fruits (such as grapefruits), demonstrates anti-inflammation, anti-oxidant, anti-proliferation, anti-tumor effects. Meanwhile, association of Naringin process EndMT still unclear. In this study, monocrotaline (MCT)...
Pulmonary arterial hypertension (PAH) is a fatal syndrome resulting from enhanced pulmonary pressure and vessel resistance. Perivascular inflammation extracellular matrix deposition are considered to be the crucial pathophysiologic bases of PAH. Formononetin (FMN), natural phytoestrogen isolated red clover (Trifolium pratense), has variety proapoptotic, anti‑inflammatory anti‑tumor activities. However, therapeutic effectiveness FMN for PAH remains unclear. In present study, 60 mg/kg...