A5101625965- Platelet Disorders and Treatments
- Pancreatic function and diabetes
- Patient-Provider Communication in Healthcare
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Hippo pathway signaling and YAP/TAZ
- Neuropeptides and Animal Physiology
- Bone health and osteoporosis research
- Patient Dignity and Privacy
- Palliative Care and End-of-Life Issues
- Galectins and Cancer Biology
- Healthcare Decision-Making and Restraints
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Folate and B Vitamins Research
- Artificial Intelligence in Healthcare and Education
- Family and Patient Care in Intensive Care Units
- Knee injuries and reconstruction techniques
- Cancer, Lipids, and Metabolism
- Nursing Roles and Practices
- Periodontal Regeneration and Treatments
- Macrophage Migration Inhibitory Factor
Integrated Chinese Medicine (China)
2025
Hangzhou Normal University
2012-2024
Zhejiang University
2011-2023
University of California, San Diego
2015
Moores Cancer Center
2015
Thomas Jefferson University
2012
Wenzhou Medical University
2012
Abstract The Hippo pathway regulates cell proliferation, apoptosis, and stem self-renewal, its inactivation in animal models causes organ enlargement followed by tumorigenesis. deregulation occurs many human cancers, but the underlying mechanisms are not fully understood. Here, we report tyrosine phosphorylation of tumor suppressor LATS1 as a mechanism regulation adhesion. A kinase library screen identified Src to directly phosphorylate on multiple residues, causing attenuated Mob activator...
To explore the attitudes of healthcare professionals and public on applying ChatGPT in clinical practice. The successful application practice depends technical performance critically perceptions non-healthcare healthcare. This study has a qualitative design based artificial intelligence. was divided into five steps: data collection, cleaning, validation relevance, sentiment analysis, content analysis using K-means algorithm. comprised 3130 comments amounting to 1,593,650 words. dictionary...
Osteoarthritis (OA) is the most common age-related degenerative joint disease and platelet-rich plasma (PRP) has been shown to be beneficial in OA. Therefore, this study, we aimed investigate effects of platelets on chondrocytes underlying mechanisms. Anabolic catabolic activity proliferation rate were evaluated after co-culture with platelets. Chondrocyte gene expression was measured by real-time PCR. protein phosphorylation western blot. Chondrocytes treated or without transplanted into a...
Background: Primary nurses hesitated to communicate directly with leaders about safety concerns due apprehension confrontation, fear of blame, and their undervalued opinions. Affective leadership’s impact on voice behaviors was characterized by top–down impression management an absence upward management. This study aimed validate the mediating role workplace networking between affective leadership employee behaviors. Methods: a cross‐sectional survey, using purposive sampling select 639 from...
This study aimed to explore the public and medical professionals’ concerns attitudes toward nurse prescribing using text-mining method analyze social media data. Python was used automatically mine data related keywords “nurse prescribing” “prescription” that were posted on four Chinese internet platforms between January 1, 2017, November 2022. The included sites such as Zhihu Weibo, well forums like Aiaiyi Medical Hotspot Dingxiangyuan Medicine. We conducted personnel, topic, sentiment...
Nicotinic acid (niacin) has been widely used as a lipid-lowering drug for several decades, and recently, orphan G protein-coupled receptor GPR109A identified niacin. Mechanistic investigations have shown that, upon niacin activation, couples to Gi protein inhibits adenylate cyclase activity, leading inhibition of liberation free fatty acid. However, the underlying molecular mechanisms signaling remain largely unknown. Using CHO-K1 cells stably expressing A431 cells, which are human...
The human hydroxycarboxylic acid receptor 2 (HCA<sub>2</sub>), also known as GPR109A and HM74a, was first identified a niacin has recently received significant attention because of its potential to clinically modify plasma lipids in favorable manner. Our recent studies have demonstrated that the niacin-induced internalization HCA<sub>2</sub> receptors is regulated by G protein-coupled kinase (GRK) arrestin3 internalized rapidly recycle back cell surface. investigation presented here used...
Abstract Background Surrogate decision–makers (SDMs) who make decisions for critically ill patients often face great challenges. Although shared decision‐making has been advocated, its implementation less than satisfactory. Aim To explore the experience of surrogate process and determine how SDMs understand values preferences patients. Study Design A constructivist qualitative study was used. The data were collected using semistructured interviews with four questions conducted between...
Objective: To determine the killing effects on extracorporeal HepG2 cells under different temperatures, pressures of permeability and lengths treatment time. Method: According to treating time, human hepatoma cell-line were grouped 80 groups. Cell index (CI) as measurement effect calculated by monotetrazolium (MTT) methods, i.e., CI =1- (the OD value in treated group - blank control group) / (mean untreated mean group). factorial design, data fed into SPSS 10.0 analyzed three-way ANOVA...