A5040057942- Natural Compounds in Disease Treatment
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Computational Drug Discovery Methods
- Pulmonary Hypertension Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Autophagy in Disease and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Traditional Chinese Medicine Studies
- Cardiovascular Disease and Adiposity
- Ginger and Zingiberaceae research
- Natural product bioactivities and synthesis
- Biomarkers in Disease Mechanisms
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Ion Transport and Channel Regulation
- Polysaccharides and Plant Cell Walls
- Neuroscience and Neuropharmacology Research
- Cardiac Imaging and Diagnostics
- Bioactive Compounds and Antitumor Agents
- Artificial Intelligence in Healthcare and Education
- Medical Research and Treatments
Sichuan University
2025
Guiyang Medical University
2024-2025
Binzhou Medical University
2024
Wenzhou Medical University
2015-2024
Henan University
2024
Zhengzhou University
2024
Ningbo University
2023-2024
Henan Provincial People's Hospital
2024
Imperial College Healthcare NHS Trust
2022
Public Health England
2022
Hemodialysis (HD) and peritoneal dialysis (PD) are important renal replacement treatment in end stage disease (ESRD), but the comparison of quality life (QOL) causes hospitalisation between two modalities China is lacking. In present study, we compared a multi-center study.Six hundred fifty four HD 408 PD patients were investigated from 10 hospitals Sept, 2004 to Jan, 2005. Among patients, there 360 males 294 females with mean age 57.22 +/- 12.49 years (18-88 y). 165 243 females, 61.59 12.65...
The aim of the present study was to investigate protective effect salvianolic acid A (SAA) on myocardial ischemia/reperfusion injury in rats. SAA (10 mg/kg) or Tirofiban (60 µg/kg) administered rats by jugular vein injection 10 min before initiation reperfusion. After 3 h reperfusion, platelet aggregation measured using an aggregometer and levels nitric oxide (NO) were detected ultraviolet spectrophotometer. Serum cardiac troponin T (cTnT), creatine kinase isoenzyme MB (CK-MB), p-selectin,...
Recent studies have indicated that the insula underlies affective learning. Although learning is well-established in development of opiate addiction, role this context remains unclear. To elucidate organization opiate-related within insular cortex, we reversibly inactivated each two major subdivisions rats and tested effects inactivation on acquisition morphine-induced conditioned place preference (CPP) aversion (CPA) induced by naloxone-precipitated acute morphine withdrawal. Results showed...
Schisandrin B (ScB), isolated from Schisandra chinensis ( S. ), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects. However, it unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model. In this study, (20 mg/kg, 40 80 mg/kg) was administered via oral gavage once daily for 5 days before the surgery. After 6 h ischemia 24 reperfusion of left limb, reduced I/R induced histological changes edema. suppressed...
Vitamin C (ascorbic acid) is a nutrient used to treat cardiovascular disease (CVD). However, the pharmacological targets of vitamin and mechanisms underlying therapeutic effects on CVD remain be elucidated. In this study, we network pharmacology approach investigate for treatment CVD. The core targets, major hubs, enriched biological processes, key signaling pathways were identified. A protein-protein interaction an diagram target-related constructed. Three identified, including...
Objective The objective of this study was to investigate the potential association between dietary fiber intakes and prevalence chronic inflammatory airway diseases (CIAD), as well mortality in participants with CIAD. Methods Data collected from National Health Nutrition Examination Survey (NHANES) 2013–2018, being calculated average two 24-h reviews divided into four groups. CIAD included self-reported asthma, bronchitis, obstructive pulmonary disease (COPD). Through December 31, 2019,...
BackgroundGlobally, cardiovascular disease (CVD) has emerged as a leading cause of mortality. Bisphenol A (BPA), recognized one the most prevalent and widely distributed endocrine-disrupting chemicals (EDCs), been consistently linked to progression CVD. This research centers on unraveling molecular mechanisms responsible for toxic effects BPA exposure Key targets pathways involved in action CVD were investigated by network toxicology. Binding abilities core evaluated docking.Methods...
Drug-associated cues can elicit relapse to drug seeking after abstinence. Studies with extinction–reinstatement models implicate dopamine (DA) in the nucleus accumbens shell (NAshell) and dorsolateral caudate-putamen (dlCPu) cocaine seeking. However, less is known about their roles cue-induced opiate prolonged Using a morphine self-administration abstinence–relapse model, we explored of NAshell dlCPu DA D1/D2-like receptor mechanisms underlying rewarding and/or Acquisition was examined...
Abstract The excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are mainly responsible for occlusion diseases, such as pulmonary arterial hypertension restenosis. Our previous study demonstrated thymoquinone (TQ) attenuated monocrotaline‐induced hypertension. aim the present is to systematically examine inhibitory effects TQ on platelet‐derived growth factor‐BB (PDGF‐BB)–induced VSMCs in vitro neointimal formation vivo elucidate potential mechanisms. Vascular were...
Pulmonary arterial hypertension (PAH) is a life‑threatening disease induced by the excessive proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Formononetin (FMN) natural isoflavone with numerous cardioprotective properties, which can inhibit induce tumor cells; however, whether FMN has therapeutic effect on PAH remains unclear. In present study, was in rats monocrotaline (MCT, 60 mg/kg); were then administered (10, 30 or mg/kg/day). At end experiment,...
Abstract Introduction Three percent sodium chloride (NaCl) treatment has been shown to reduce brain edema and inhibited aquaporin 4 (AQP4) expression in bacterial meningitis induced by Escherichia coli . Lipopolysaccharide (LPS) is the main pathogenic component of E. We aimed explore effect 3% NaCl mouse LPS, as well elucidate potential mechanisms action. Methods was used treat cerebral LPS mice vivo Brain water content, IL-1β, TNFα, immunoglobulin G (IgG), AQP4 mRNA protein were measured...
Graphical Abstract Gal-3 triggers myocardial apoptosis, oxidative stress, inflammatory cytokines release, macrophage infiltration, and fibrosis, leading to cardiac dysfunction in DCM mice.
The natural medicinal monomer, schisandrin B (Sch B), has been shown to exert cardioprotective effects; however, the underlying mechanisms of these effects remain be fully elucidated. Therefore, aim present study was investigate whether Sch attenuated myocardial ischemia/reperfusion (I/R) injury via phosphoinositide 3‑kinases (PI3K)/Akt signaling pathway. To confirm this, I/R models were established in rats by ligation left anterior descending coronary artery. A group animals administered...
Abstract Left atrial (LA) remodeling has been identified to predict fibrillation (AF) and heart failure. However, the role of LA diameter (LAD) in patients with failure (HF) preserved (HFpEF), mid-range (HFmrEF), reduced ejection fraction (HFrEF) remains poorly understood. A total 142 including 71 subjects AF (21 HFpEF, 22 HFmrEF, 28 HFrEF) (EF)-matched sinus rhythm (SR) were included study. Baseline characteristics echocardiographic parameters LAD compared between both groups as well among...