A5080016588- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Plant-derived Lignans Synthesis and Bioactivity
- Vibrio bacteria research studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bacterial Identification and Susceptibility Testing
- Peroxisome Proliferator-Activated Receptors
- Atmospheric Ozone and Climate
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bioactive natural compounds
- Endoplasmic Reticulum Stress and Disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Cholesterol and Lipid Metabolism
- Animal Nutrition and Physiology
- Atmospheric aerosols and clouds
- Heavy Metal Exposure and Toxicity
- Neutropenia and Cancer Infections
- Cell death mechanisms and regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Machine Learning in Healthcare
- Entomological Studies and Ecology
- Acute Myocardial Infarction Research
Wenzhou Medical University
2017-2025
First Affiliated Hospital of Wenzhou Medical University
2020-2025
Wenzhou University
2024-2025
Zhejiang Hospital
2024-2025
Zhejiang Medicine (China)
2025
Anyang Hospital of Traditional Chinese Medicine
2024
Affiliated Hospital of Guizhou Medical University
2024
Guiyang Medical University
2024
Xuzhou Medical College
2021-2024
Lianyungang Oriental Hospital
2021-2024
Disordered coagulation is an independent risk factor for mortality in patients with sepsis and currently lacks effective therapeutic strategies. In this study, PIM1, a novel target predominantly expressed macrophages during sepsis, investigated by bioinformatics analysis clinical evaluation compared healthy individuals. The regulatory mechanism which PIM1 promotes the release of tissue factors (TF) from modulating phosphorylation levels mTOR through AKT MAPK signaling pathways demonstrated...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease. This study aimed to investigate the involvement of endoplasmic reticulum stress (ERS) in IPF and explore its correlation with immune infiltration. ERS-related differentially expressed genes (ERSRDEGs) were identified by intersecting (DEGs) from three Gene Expression Omnibus datasets gene sets. Set Variation Analysis Ontology used potential biological mechanisms underlying ERS. A nomogram was developed...
Abstract This study was conducted to estimate the effect of dietary conjugated linoleic acids (CLA) on intramuscular and subcutaneous fat deposition in Yellow Breed × Simmental cattle. The experiment for 60 days. results showed that average backfat thickness, (testicles + kidney pelvic) percentage CLA were significantly lower than control group, while higher. Compared Longissimus muscle enzyme activities lipoprotein lipase (LPL), fatty acid synthase (FAS) acetyl‐coenzyme A carboxylase (ACC)...
Schisandrin B (ScB), isolated from Schisandra chinensis ( S. ), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects. However, it unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model. In this study, (20 mg/kg, 40 80 mg/kg) was administered via oral gavage once daily for 5 days before the surgery. After 6 h ischemia 24 reperfusion of left limb, reduced I/R induced histological changes edema. suppressed...
Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship limited in Japan. The purpose of study was to evaluate the correlation between TyG and risk T2DM Japanese population. Here, 12732 participants were selected from NAGALA (NAfld Gifu Area, Longitudinal Analysis) conducted 2004 2015 for a retrospective cohort analysis. association assessed using Cox proportional-hazard model. Subgroup analyses according age, sex, smoking...
Water vapour is an important atmospheric gas with a direct impact on climate and weather. Given the significant variations of water distribution in tridimensional temporal space, it great significance to use remote sensing data monitor large scale. One main missions Medium Resolution Spectral Imager (MERSI) onboard FengYun (FY)-3A satellite precipitable (PWV). However, official MERSI PWV not widely used due limitation its accuracy. The primary objective this study develop FY-3A/MERSI higher...
This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used assess risk factors for 28-day mortality. We also monitored pathogen load together with clinical indicators subgroup cohort. A total 107 patients positive baseline DDPCR results included. Detection poly-microorganisms [adjusted hazard ratio (HR) = 3.19; 95%...
NLRP6 inflammasome, one of the important intracellular innate immune sensors, has been shown to regulate responses. However, its roles in intracerebral hemorrhage (ICH) are completely not clear. In present study, we investigated expression profile and biological inflammasome perihematomal brain tissues mice subjected ICH. this explored role upon acute injury Increased was found ranging from 6 h 3 d, with a peak level at 1 d after Immunohistochemistry staining also showed that significantly...
The natural medicinal monomer, schisandrin B (Sch B), has been shown to exert cardioprotective effects; however, the underlying mechanisms of these effects remain be fully elucidated. Therefore, aim present study was investigate whether Sch attenuated myocardial ischemia/reperfusion (I/R) injury via phosphoinositide 3‑kinases (PI3K)/Akt signaling pathway. To confirm this, I/R models were established in rats by ligation left anterior descending coronary artery. A group animals administered...
Platelets in patients with type 2 diabetes mellitus (DM2) are characterized by increased activation and aggregation, which tends to be associated a high morbidity mortality due cardiovascular disease (CVD). Moreover, large proportion of DM2 show an inadequate response standard antiplatelet treatments, contributing recurrent events. In our previous study, we indicated that Salvianolic acid A (SAA) presents effect healthy volunteers. However, whether it can inhibit "activated platelets"...
Thrombocytopenia is common among sepsis patients. Platelet transfusions are frequently administered to increase platelet counts, but their clinical impacts remain unclear in sepsis-induced thrombocytopenia. The goal of this study was explore the association between transfusion and mortality patients with thrombocytopenia.The based on Medical Information Mart for Intensive Care (MIMIC) III database. Septic severe thrombocytopenia (a count ≤ 50/nl) were included divided into two groups: a...
ABSTRACT Objective: To achieve a better prediction of in-hospital mortality, the Sequential Organ Failure Assessment (SOFA) score needs to be adjusted and combined with comorbidities. This study aims enhance SOFA for mortality in patients Sepsis-3. Methods: maximum within first 3 days (Max Day3 SOFA) relation using logistic regression incorporated age-adjusted Charlson Comorbidity Index (aCCI) as continuous variable build Index-Sequential (aCCI-SOFA) model. The outcome was mortality. We...
Sepsis is still a major public health concern and medical emergency due to its high morbidity mortality. Accurate timely etiology diagnosis crucial for sepsis management. As an emerging rapid sensitive pathogen detection tool, digital droplet PCR (ddPCR) has shown promising potential in identification of pathogens antimicrobial resistance genes. However, the diagnostic value clinical impact ddPCR tests remains be studied patients with suspected sepsis. PROGRESS trial aimed evaluate...
This study investigates the role of long non-coding RNA EGOT in colorectal cancer (CRC) by examining its expression 40 pairs CRC and adjacent normal tissues assessing impact on clinical outcomes. was found to be downregulated tissues, low levels were associated with a higher likelihood lymphatic distant metastasis, as well poorer overall progression-free survival patients. Functional experiments revealed that overexpression SW480 cells reduced cell viability, migration, wound closure, while...
<title>Abstract</title> Lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a transmembrane protein that belongs to the C-type lectin family and plays significant role in various diseases by promoting release of inflammatory mediators enhancing cellular responses oxidative stress. Studies have demonstrated sepsis, activation LOX-1 promotes procoagulant phenotype endothelial cells. The aim this study was investigate whether inhibition could ameliorate coagulation dysfunction...
Objectives: To investigate the predictive value of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) before percutaneous intervention (PCI) to predict target vessel failure (TVF) after stent implantation. Methods: This retrospective study included 429 patients (429 vessels) who underwent PCI and implantation CCTA within 3 months. All between January 2012 December 2019. A dedicated workstation (Syngo Via, Siemens) was used analyze measure CT-FFR value. The...
Abstract Background: Evidences regarding the association between triglyceride-glucose index (TyG) and Nonalcoholic fatty liver (NAFLD) are controversial. Therefore, goals of this research to evaluate whether TyG is independently associated with NAFLD ability detect in Japanese population. Methods: The present study was a cross-sectional study. data downloaded from DATADRYAD website. A total 13178 participants involved hospital Japan 2004 2015. correlation detected by using binary logistic...
Abstract Background: The association of platelet transfusion and short-term mortality in patients with sepsis-induced thrombocytopenia remains unclear. Therefore, we intended to explore whether could make a difference for thrombocytopenia. Methods: study was based on the Medical Information Mart Intensive Care (MIMIC) III database. Sepsis were divided into those or without (Platelet Transfusion group [PT group] No Platelet [NPT group], respectively) during hospital stay. primary outcome...
Abstract Background: Thrombocytopenia is common among sepsis patients. Platelet transfusion frequently administered to increase platelet counts but its clinical impacts remains unclear in sepsis-induced thrombocytopenia. Therefore, we intended explore the association between and mortality patients with Methods: The study was based on Medical Information Mart for Intensive Care (MIMIC) III database. Sepsis were divided into two groups: group (PT group) no (NPT group). primary outcome 28-day...
Abstract Thrombocytopenia is common among sepsis patients. Platelet transfusion frequently administered to increase platelet counts but its clinical impacts remain unclear in sepsis-induced thrombocytopenia. The goal of this study was explore the association between and mortality patients with thrombocytopenia based on Medical Information Mart for Intensive Care (MIMIC) III database. In study, we included 1733 thrombocytopenia, these were divided into two groups: group (PT group) no (NPT...
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