A5054818585- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver physiology and pathology
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- MicroRNA in disease regulation
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Fibroblast Growth Factor Research
- Medical Imaging and Pathology Studies
- Medicinal plant effects and applications
- Cancer Cells and Metastasis
- Bioinformatics and Genomic Networks
- Connective Tissue Growth Factor Research
- Chemotherapy-induced organ toxicity mitigation
Guiyang Medical University
2016-2024
The First People's Hospital of Guiyang
2022-2024
Affiliated Hospital of Guizhou Medical University
2016-2024
The Fourth People's Hospital
2024
Soochow University
2015-2023
Shanghai Public Health Clinical Center
2023
University of Alabama at Birmingham
2020
First Affiliated Hospital of Soochow University
2015-2016
Idiopathic pulmonary fibrosis (IPF) seriously threatens human life and health, no curative therapy is available at present. Nintedanib the first agent approved by US Food Drug Administration (FDA) in order to treat IPF; however, its mechanism of inhibition IPF still elusive. According recent studies, nintedanib a potent inhibitor. It can antagonize platelet-derived growth factor (PDGF), basic fibroblast (b-FGF), vascular endothelial (VEGF), etc., inhibit fibrosis. Whether there are other...
Lung fibrosis is a major medical problem for the aging population worldwide. Fibroblast migration plays an important role in fibrosis. Focal Adhesion Kinase (FAK) senses extracellular stimuli and initiates signaling cascades that promote cell migration. This study first examined dose time responses of FAK activation human lung fibroblasts treated with platelet derived growth factor BB (PDGF-BB). The data indicate directly recruited by integrin β1 subsequent required fibroblast on...
Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HSCs) activation vitro and progression vivo. FAK associated with increased expression α-smooth muscle actin (α-SMA) collagen fibrotic live tissues. Transforming growth factor beta-1 (TGF-β1) induces time dose dependent manner. precedes α-SMA HSCs. Inhibition blocks expression,...
Changes in intestinal microecology during acute liver failure (ALF) directly affect the occurrence and development of disease. The study aimed to investigate relationship between microbiota key immune cells. Fecal transplantation (FMT) was used determine whether ALF can balance Th17/Treg cytokines. gut clinical indicators analyzed. BALB/c mice were treated with D-galactosamine (D-GalN) induce a murine model. FMT D-GalN conducted test for function indicators. Results showed that proportions...
Hepatic stellate cells (HSCs) are the primary cell type responsible for liver fibrosis. Our study proved that thymosin beta 4 (Tβ4) has anti-fibrogenic effects in HSCs through PI3K/AKT pathway. However, underlying mechanisms not fully elucidated. Circular RNAs (circRNAs) play important roles fine-tuning gene expression and often deregulated cancers. profile clinical significance of fibrosis is still unknown. Therefore, we hypothesize Tβ4 influences circRNAs fibrosis.Circular RNA microarray...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease. This study aimed to investigate the involvement of endoplasmic reticulum stress (ERS) in IPF and explore its correlation with immune infiltration. ERS-related differentially expressed genes (ERSRDEGs) were identified by intersecting (DEGs) from three Gene Expression Omnibus datasets gene sets. Set Variation Analysis Ontology used potential biological mechanisms underlying ERS. A nomogram was developed...
In order to clarify the risk of hematotoxicity carboplatin, we inspected 19901 case reports non-small cell lung cancer patients that were submitted FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These comprised 3907 cases which treated with carboplatin 15994 other therapies in absence carboplatin. By comparison, significantly more likely report anemia (OR = 2.27, 95% CI 1.85-2.78, P 5.04×10-15), neutropenia 1.76-2.92, 2.39×10-10), thrombocytopenia 2.38,...
BACKGROUNDMassive hepatocyte death is the core event in acute liver failure (ALF). Gasdermin D (GSDMD)-mediated pyroptosis a type of highly inflammatory cell death. However, role and its mechanisms expanding responses ALF are unclear. AIMTo investigate GSDMD-mediated through vitro vivo experiments. METHODSThe expression pathway-associated proteins tissues from patients injury model was examined by Western blot. GSDMD short hairpin RNA (shRNA) used to effects downregulation on monocyte...
Nintedanib is an effective treatment for pulmonary fibrosis (PF), but the exact mechanism by which this agent works to delay progression of PF remains unclear. In study, we explored whether nintedanib alleviates at least partially inhibiting focal adhesion kinase (FAK)/ERK/S100A4 signalling pathway. Bleomycin (BLM) was used induce in a mouse model, and human fetal lung fibroblast 1 (HFL-1) cells were exposed transforming growth factor-β (TGF-β1) create vitro model PF. both models,...
Amifostine is a normal cell protection agent, not only used in the adjuvant therapy of lung cancer, ovarian breast nasopharyngeal bone tumor, digestive tract blood system tumor and other cancers order to reduce toxicity chemotherapy drugs, recent studies have reported that drug can also tissue damage patients with pulmonary fibrosis, but its mechanism action yet fully understood. In this study, we explored potential therapeutic effects molecular mechanisms AMI on bleomycin (BLM)-induced...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease of unknown etiology, characterized by diffuse alveolitis and alveolar structural damage. Due to the short median survival time poor prognosis IPF, it particularly urgent find new IPF biomarkers. Previous studies have shown that basement membranes (BMs) are associated with development tumor metastasis. However, there still lack research on BMs-related genes in IPF. Therefore, we investigated expression...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by unexplained irreversible fibrosis. Although the etiology of IPF unclear, studies have shown that it related to telomere length shortening. However, prognostic value telomere-related genes in has not been investigated.
Liver fibrosis is a necessary stage for chronic liver diseases, and serious threat to human health. Hepatic diseases. stellate cells (HSCs) are the primary cell type responsible fibrosis. Thymosin beta 4 (Tβ4) has potential role in pathogenesis of that it especially associated with activation HSCs, however, underlying mechanisms not fully elucidated. Herein, we investigated Tβ4 by describing effects Tβ4, discuss possible signaling pathway regulated Tβ4. The expression was significantly...
// Lei Yu 1, 2, * , Bao-fang Zhang 3, Ming-liang Cheng 2 Xue-ke Zhao Quan Ya-xin Hu Hua-juan Liu Mao Mu Bi Wang 4 Guo-zhen Yang Li-li Zhu Shuai 5 Yu-mei Yao Yi-ju Wang-sheng Li 6 1 The First Affiliated Hospital of Jinan University, Guangdong 510632, Guangzhou, China Hospital, Guizhou Medical Guiyang 550004, Guizhou, 3 Soochow Suzhou 215006, Jiangsu, Department Eugenics and Genetics, Maternal Child Health-Care 550003, Interventional Radiology, Cancer Clinical Laboratory, Liupanshui...
Abstract Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality. Here, we aimed to explore the roles potential correlation of placenta polypeptide injection (PPI) MMP‐9/TIMP‐1 signaling pathway in COPD. BEAS‐2B cells were treated with cigarette smoke extract (CSE) establish a COPD cell model vitro. The survival cytotoxic effect measured by CCK‐8, LDH release flow cytometry assays. inflammatory responses determined western blot ELISA assay. Cell fibrosis was assessed...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive form of unknown etiology. Despite ongoing research, there currently no cure for this disease. Recent studies have highlighted the significance competitive endogenous RNA (ceRNA) regulatory networks in IPF development. Therefore, study investigated ceRNA network associated with pathogenesis. We obtained gene expression datasets (GSE32538, GSE32537, GSE47460, and GSE24206) from Gene Expression Omnibus (GEO) database...
This investigation explored the mechanism by which total flavonoids of
Background: To investigate the therapeutic property for Danshen in development of COPD using SD rats as animal model. Methods: a total 30 were consecutively exposed cigarette smoke three months, and Broncho-alveolar lavage fluid (BALF) was collected followed sacrifice. These randomly divided five groups determined by approaches treatment (COPD group: smoke+ Sodium Chloride 0.2ml/100g; Control: only to ambient air+ A, B C groups: smoke+Danshen 0.1, 0.2, 0.4 ml/100g respectively). The level...
The abundance of circulating monocytes is closely associated with the development atherosclerosis in humans.
Abstract Background The combination of the endocannabinoid system (ECS) and type 2 cannabinoid receptor (CB2R) can activate various signal pathways, leading to distinct pathophysiological roles. This interaction has gained significant attention in recent research on fibrosis diseases. Focal adhesion kinase (FAK) plays a crucial role regulating signals from growth factor receptors Integrins. It is also involved transformation fibroblasts into myofibroblasts. study aims investigate impact CB2R...