A5109934065- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Medical Image Segmentation Techniques
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Image Retrieval and Classification Techniques
- Neurological disorders and treatments
- Health, Environment, Cognitive Aging
- Brain Tumor Detection and Classification
- Chaos control and synchronization
- Diet and metabolism studies
- Neural dynamics and brain function
- Acoustic Wave Resonator Technologies
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Parkinson's Disease Mechanisms and Treatments
- Image and Signal Denoising Methods
- Nutritional Studies and Diet
- Optical Imaging and Spectroscopy Techniques
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
Beijing Tian Tan Hospital
2017-2024
Capital Medical University
2017-2024
Beijing YouAn Hospital
2024
National Clinical Research Center for Digestive Diseases
2018-2024
Wenzhou Medical University
2015-2023
Chongqing University of Technology
2019-2023
Pennsylvania State University
2023
Lishui Central Hospital
2015-2023
First Affiliated Hospital Zhejiang University
2023
Zhejiang University
2007-2023
Prediction of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is major interest in AD research. A large number potential predictors have been proposed, with most investigations tending examine one or a set related predictors. In this study, we simultaneously examined multiple features different modalities data, including structural magnetic resonance imaging (MRI) morphometry, cerebrospinal fluid (CSF) biomarkers and neuropsychological functional measures (NMs),...
We investigated the key neurodevelopmental factors that determine cortical thickness, namely synaptogenesis and regression, by analyzing thickness of visual cortex in humans with early- late-onset blindness. The bilateral cortices early blind were significantly thicker than those late sighted controls, but latter two groups did not differ significantly. This suggests reduced “pruning” synapses cortex, which may be due to a lack experience during critical developmental period. These findings...
There have been many attempts at explaining age-related cognitive decline on the basis of regional brain changes, with usual but inconsistent findings being that smaller gray matter volumes in certain regions predict worse performance specific domains. Additionally, compromised white integrity, as suggested by hyperintensities or decreased fractional anisotropy, has an adverse impact functions. The human is, however, a network and it may be more appropriate to relate functions properties...
Anomalously abrupt nucleation and growth kinetics in polarization switching of wurtzite ferroelectrics are demonstrated. The anomaly inspires an extension the traditional model to a regime that simultaneous non-linear occur.
Alzheimer's disease (AD) is characterized by an insidious onset of progressive cerebral atrophy and cognitive decline. Previous research suggests that cortical folding sulcal width are associated with function in elderly individuals, the aim present study was to investigate these morphological measures patients AD. The sample contained 161 participants, comprising 80 normal controls, 57 very mild AD, 24 From 3D T1-weighted brain scans, automated methods were used calculate index global...
Intimal calcification is highly correlated with atherosclerotic plaque burden, but the underlying mechanism poorly understood. We recently reported that cartilage oligomeric matrix protein (COMP), a component of vascular extracellular matrix, an endogenous inhibitor smooth muscle cell calcification.To investigate whether COMP affects calcification.ApoE(-/-)COMP(-/-) mice fed chow diet for 12 months manifested more extensive in innominate arteries than did ApoE(-/-) mice. To which origins...
This study examined the heritability of brain grey matter structures in a subsample older adult twins (93 MZ and 68 DZ twin pairs; mean age 70 years) from Older Australian Twins Study. The estimates subcortical regions ranged 0.41 (amygdala) to 0.73 (hippocampus), cortical regions, 0.55 (parietal lobe) 0.78 (frontal lobe). Corresponding two hemispheres were influenced by same genetic factors high correlations observed between hemispheric regions. There three genetically correlated clusters,...
Background and purpose Cardiovascular diseases dementia are two major in the elderly. Atherosclerosis is associated with future vascular events cognitive impairment. The PolyvasculaR Evaluation for Cognitive Impairment vaScular Events (PRECISE) study a population-based prospective cohort comprehensive evaluation of multiterritorial artery stenosis plaque using advanced imaging techniques collection assessments. Methods Between May 2017 September 2019, PRECISE enrolled 3067 community-dwelling...
Identifying Alzheimer's disease (AD) at its early stage is of major interest in AD research. Previous studies have suggested that abnormalities regional sulcal width and global index (g-SI) are characteristics patients with early-stage AD. In this study, we investigated three other common neuroimaging morphological measures (cortical thickness, cortical volume, subcortical volume) to identify These were evaluated 150 participants, including 75 normal controls (NC) The the five individual...
Emerging evidence from lesion-symptom mapping (LSM) studies suggested that regional white matter lesions (WML) on strategic (WM) fiber tracts are significantly associated with specific cognitive domains, independent of global WML burden. However, previous LSM investigations were mostly carried out in disease cohorts, little community-based older individuals, making findings difficult to generalize. Moreover, most applied a threshold the probabilistic atlas, leading loss information and...
Abstract White matter hyperintensities (WMHs) represent the most common neuroimaging marker of cerebral small vessel disease (CSVD). The volume and location WMHs are important clinical measures. We present a pipeline using deep fully convolutional network ensemble models, combining U‐Net, SE‐Net, multi‐scale features, to automatically segment estimate their volumes locations. evaluated our method in two datasets: routine dataset comprising 60 patients (selected from Chinese National Stroke...
OBJECTIVE To investigate the contribution of alterations in brain structure and function to cognitive their interactions individuals with diabetes patients type 2 mellitus (T2DM). RESEARCH DESIGN AND METHODS This population-based study included 2,483 participants who underwent structural MRI (n = 569 normal glucose metabolism [NGM], n 1,353 prediabetes, 561 T2DM) testing. Of these, 2145 also functional 496 NGM, 1,170 479 T2DM). Multivariate linear regression models were used assess...