A5087254555- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Treatment of Major Depression
- Workplace Health and Well-being
- Genetic and Kidney Cyst Diseases
- Family Caregiving in Mental Illness
- Renal and Vascular Pathologies
- Neuroscience and Neuropharmacology Research
- Cardiac Health and Mental Health
- Stroke Rehabilitation and Recovery
- Fatty Acid Research and Health
- Neurosurgical Procedures and Complications
- Clinical practice guidelines implementation
- Tryptophan and brain disorders
- Neuroscience and Music Perception
UNSW Sydney
2018-2025
Prince of Wales Hospital
2018-2021
Prince of Wales Hospital
2021
Neuroscience Research Australia
2018
The University of Sydney
2011-2015
University College London
2008-2009
Mental Health Research UK
2008
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
Subjective memory complaints (SMC) are common but their significance is still unclear. It has been suggested they a precursor of mild cognitive impairment (MCI) or dementia and an early indicator decline. Vascular risk factors have important role in the development possibly MCI. We therefore aimed to test hypothesis that vascular were associated with SMC, independent psychological distress, middle-aged community-dwelling population. A cross-sectional analysis baseline data from 45 Up Study...
<h3>Objective</h3> To determine whether severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over 4 8 years, respectively, we analyzed data from a prospective cohort study. <h3>Methods</h3> A total of 414 community-dwelling older adults aged 72–92 years were assessed at baseline biennially for up to assessments, consensus diagnoses, 3T MRI. The numbers PVS in 2 representative slices the basal ganglia (BG) centrum semiovale (CSO)...
With the rise in ageing population and absence of a cure for dementia, cost-effective prevention strategies those 'at risk' dementia including with depression and/or mild cognitive impairment are urgently required.This study evaluated efficacy multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program older adults dementia.Using single-blinded design, 64 participants (mean age = 66.5 years, SD 8.6) were randomized to an immediate treatment or treatment-as-usual control arm. The...
We aimed to compare the rates of burden amongst caregivers participants with mild cognitive impairment (MCI), compared a control group. also identify factors in both caregiver and patient that are associated significant levels burden.This was cross-sectional study. Sixty-four MCI, 36 control-participants their respective caregivers/informants were recruited university research clinic. The proportion those who showed clinically determined by Zarit Burden Interview score >21. associations...
Abstract INTRODUCTION A lack of national consensus on the roles and responsibilities Australian memory cognition clinics contributes to large variability seen across services. The introduction guidelines a quality assessment framework could facilitate greater harmonization improvements. METHODS We used modified Delphi process develop guidelines. Pilot completed self‐assessment, case‐note audit, review meeting evaluate their service against RESULTS final included 160 standards 14 different...
Emerging evidence from lesion-symptom mapping (LSM) studies suggested that regional white matter lesions (WML) on strategic (WM) fiber tracts are significantly associated with specific cognitive domains, independent of global WML burden. However, previous LSM investigations were mostly carried out in disease cohorts, little community-based older individuals, making findings difficult to generalize. Moreover, most applied a threshold the probabilistic atlas, leading loss information and...
Aims: To examine the rates and clinical characteristics of mild cognitive impairment (MCI) in older people with depressive symptoms to determine relative contribution hippocampal volume MCI memory change. Method: One hundred fifty-two participants lifetime Major Depression remitted or 28 healthy controls underwent psychiatric neuropsychological assessments. Magnetic resonance imaging was also conducted a subset patients (n = 81) 18). Results: diagnosed 75.7% associated increasing age,...
Vascular dementia (VaD) is a complex neurocognitive disorder secondary to variety of cerebrovascular lesions. Numerous studies have shown that lipid metabolism involved in the pathobiology disease. We examined plasma profiles VaD, with expectation identifying reliable biomarkers for VaD. 49 VaD patients and 48 healthy controls were recruited from Bankstown-Lidcombe Hospital Sydney, Australia. Lipids extracted by single phase 1-butanol/methanol, untargeted analysis was performed liquid...
<h3>Background:</h3> Mild cognitive impairment (MCI) and late-life depression are clinical syndromes that often co-occur may represent an early manifestation of neurodegenerative disease. The present study examined white matter microstructure in patients with MCI without a history major compared healthy controls. <h3>Methods:</h3> Older adults no (MCI), euthymic (MCI-MD) controls underwent comprehensive medical, psychiatric neuropsychological assessments. Participants also diffusion tensor...
Abstract Objectives Alzheimer's disease (AD) is associated with variable but shortened life expectancy. Knowing expected survival time may empower people AD and their families, clinicians currently have limited predictive information. Our objective was to identify determinants of in a cohort mild moderate test these on separate validation cohort. Methods We followed representative 158 for 42 months identified independent shorter survival. From we constructed the Survival Model (SAM), tested...
Objective: Depression and heart disease are major causes of early ill-health retirement. The effect comorbid depression on the award retirement in those with is unclear, however, may differ by gender. Given deleterious effects retirement, identifying at-risk groups important for guiding targeted interventions. Method: We retrospectively analysed baseline data 20,655 participants from 45 Up Study (New South Wales, Australia), who had fully retired between ages 64. examined associations then...
With estimates of dementia expected to rise over the coming decades, there is interest in understanding factors associated with promoting neuroprotection and limiting neurodegeneration. In this study, we examined change volume hippocampus a 2-month period 34 older people “at risk” cognitive decline (mean age = 66.8 years, 38% male). Factors that were included reserve, neuropsychological functioning, depression as well lifestyle (cognitive training) intervention. The results showed period,...
Dilated perivascular spaces (PVS) are a marker of small vessel disease (SVD) and common MRI finding in the elderly. Their association with cognitive impairment, particularly longitudinal decline incident dementia is unclear. Understanding this relationship has implications for our knowledge both SVD pathology more broadly. 414 community dwelling older adults aged 70–90 were assessed followed up biennially four years. The number PVS single axial slices basal ganglia (BG) centrum semi-ovale...
Abstract Perivascular space burden (PVS) is an emerging and possibly the earliest magnetic resonance imaging (MRI)-marker of cerebral small vessel disease (cSVD), a leading cause stroke dementia. Its molecular underpinnings are unknown. Genome-wide whole-exome association studies in 40,095 participants (21 population-based cohorts, 66.3±8.6 years) revealed 24 genome-wide significant PVS risk loci. These showed with white matter already at age 20, suggesting important role early-life factors....