A5042523657- Sulfur Compounds in Biology
- Functional Brain Connectivity Studies
- Nanoplatforms for cancer theranostics
- Gastric Cancer Management and Outcomes
- Microwave Engineering and Waveguides
- Congenital heart defects research
- Radio Frequency Integrated Circuit Design
- Pluripotent Stem Cells Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Nitric Oxide and Endothelin Effects
- Gastrointestinal Tumor Research and Treatment
- interferon and immune responses
- Dementia and Cognitive Impairment Research
- Supramolecular Self-Assembly in Materials
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- Helicobacter pylori-related gastroenterology studies
- Molecular Sensors and Ion Detection
- Developmental Biology and Gene Regulation
- Molecular Biology Techniques and Applications
- Advanced MRI Techniques and Applications
- Autism Spectrum Disorder Research
Southeast University
2008-2024
Center for Excellence in Molecular Cell Science
2015-2024
University of Chinese Academy of Sciences
2015-2024
Shanghai Sixth People's Hospital
2017-2024
Shanghai Jiao Tong University
2017-2024
Zhejiang University
2009-2024
Stomatology Hospital
2024
Kunming Medical University
2024
State Key Laboratory of Millimeter Waves
2023-2024
Beihua University
2024
Mercury Methylating Microbes (Hg) most commonly becomes bioavailable and enters the food web as organic form methylmercury, where it induces acute toxicity effects that can be magnified up chain. But natural anthropogenic Hg exists inorganic 2+ is only transformed into methylmercury by anaerobic microorganisms—typically sulfur-reducing bacteria. Using comparative genomics, Parks et al. (p. 1332 , published online 7 February; see Perspective Poulain Barkay ) identified two genes encode a...
Degeneration of basal forebrain cholinergic neurons (BFCNs) is associated with cognitive impairments Alzheimer's disease (AD), implying that BFCNs hold potentials in exploring stem cell-based replacement therapy for AD. However, studies on derivation from embryonic cells (ESCs) are limited, and the application ESC-derived remains to be determined. Here, we report differentiation approaches directing both mouse human ESCs into mature BFCNs. These exhibit features similar those their vivo...
Methylmercury (MeHg) is known to degrade photochemically, but it remains unclear what roles naturally dissolved organic matter (DOM) and complexing ligands play in MeHg photodegradation. Here we investigate the rates mechanisms of photodegradation using DOM with varying oxidation states origins as well molecular structures. All increased rate under solar irradiation, first-order constants varied depending on state type concentration ligands. Reduced photochemically degraded 3 times faster...
Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, genetic basis and underlying mechanisms remain unclear. Here, we generate mutant human stem cell lines (Mut hESCs) carrying NR2F1-R112K mutation that has been identified a patient with ASD features investigate their alterations. Mut hESCs overproduce ventral telencephalic neuron progenitors (ventral NPCs)...
Abstract Besides participating in diverse pathological and physiological processes, extracellular vesicles (EVs) are also excellent drug‐delivery vehicles. However, clinical drugs modulating EV levels still lacking. Here, we show that proton pump inhibitors (PPIs) reduce EVs by enhancing macropinocytosis‐mediated uptake. PPIs accelerate intestinal cell endocytosis of autocrine immunosuppressive through macropinocytosis, thereby aggravating inflammatory bowel disease. PPI‐induced...
There is growing concern about the distribution of nanoplastics (NPs) in central nervous system (CNS), whereas intrusion poorly understood. In this study, fluorescent-labeled polystyrene NPs (PS-NPs) were microinjected into different areas zebrafish embryo to mimic routes exposure. PS-NPs observed brain, eyes, and spinal cord through gametal It indicated that maternally derived specially distributed CNS during early development. Importantly, these stranded but not transferred other organs...
An aromatic peptide amphiphile was designed for delivery of the signaling gas H2S. The self-assembled in water into nanofibers that gelled upon charge screening. non-toxic gel slowly released H2S over 15 hours, and presence endothelial cells verified using a fluorescent probe.
Alzheimer's disease (AD) is characterized by memory impairments in its earliest clinical phase. The synaptic loss and dysfunction leading to failures of networks AD brain directly cause cognitive deficits patient. However, it remains unclear whether the could be repaired. In this study, we generated functional human induced neural progenitor/stem cells (iNPCs) that had been transplanted into hippocampus immunodeficient wild-type mice. grafted iNPCs efficiently differentiated neurons...
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. However, underlying molecular mechanism incompletely understood. Here we report that pro-apoptotic protein BAD as a key regulator for neuronal apoptosis, neuroinflammation and Aβ clearance in AD. activity significantly increased neurons of AD patients 5XFAD mice. Conversely, genetic disruption Bad alleles restores spatial learning memory deficits Mechanistically, phosphorylation inactivation by neurotropic...
Excessive neuroinflammation after spinal cord injury (SCI) is a major hurdle during nerve repair. Although proinflammatory macrophage/microglia-mediated plays important roles, the underlying mechanism that triggers and aggravating factors remain unclear. The present study identified role of semaphorin3C (SEMA3C) in immunoregulation SCI. SEMA3C expression level peaked 7 days post-injury (dpi) decreased by 14 dpi.
Previous studies have demonstrated lower-diffusion anisotropy within white matter in late-onset depression measured by diffusion tensor imaging, which provides information about brain integrity. We examined whether is abnormal first-episode remitted geriatric using imaging. Sixteen patients and 14 well matched healthy controls underwent tensor-imaging scans of magnetic resonance were analyzed a rigorous voxel-based approach. found that fractional was lower than at the right superior frontal...
As one of the most abundant materials in nature, lignin has been used widely co-generation operations and for fine chemicals bio-fuels production. These uses, although important, are relatively low value. Lignin contains many aromatic compounds with useful structures, it is potentially more profitable to produce high-value from low-molecular weight fraction while using high-molecular fuel or other applications. A transgenic P. putida bacterial strain PDHV85 was developed capability convert...
Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is postulated to be controlled by the endothelium, although underlying molecular mechanisms remain under investigation. Here we demonstrated that endothelial genetic deletion, using EphA4fl/fl/Tie2-Cre and EphA4fl/fl/VeCahderin-CreERT2 mice vessel painting strategies, implicated EphA4 receptor tyrosine kinase as...
Understanding of the molecular drivers lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge dynamic trajectories cell lineages across a series developmental stages gastrulation. Through computational modeling, we constructed at single-cell resolution, spatio-temporal transcriptome populations in germ-layers gastrula-stage mouse embryos. This atlas enables inference network activity underpinning specification differentiation...