A5101993502- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Psychosomatic Disorders and Their Treatments
- Alzheimer's disease research and treatments
- Neuroscience and Music Perception
- Blind Source Separation Techniques
- Advanced MRI Techniques and Applications
- Sleep and related disorders
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Resilience and Mental Health
- Action Observation and Synchronization
- Neonatal and fetal brain pathology
- Phonetics and Phonology Research
- Stuttering Research and Treatment
- Amino Acid Enzymes and Metabolism
- Mind wandering and attention
Brighton and Sussex Medical School
2015-2021
University of Sussex
2004-2020
CatScI (United Kingdom)
2016
University of Ulster
2010-2012
Queen's University Belfast
1995-2010
Belfast City Hospital
2010
Queens University
1989-2008
Deficits of the default mode network (DMN) have been demonstrated in subjects with amnestic type mild cognitive impairment (aMCI) who a high risk developing Alzheimer's disease (AD). However, no longitudinal study this has reported aMCI. Identifying links between development DMN and aMCI progression would be considerable value understanding brain changes underpinning determining conversion to AD.
Despite the high prevalence of generalized anxiety disorder (GAD) and its negative impact on society, neurobiology remains obscure. This study characterizes neurostructural abnormalities associated with key symptoms GAD, focusing indicators impaired emotion regulation (excessive worry, poor concentration, low mindfulness, physiological arousal).These domains were assessed in 19 (16 women) GAD patients healthy controls matched for age gender, using questionnaires a demand behavioral task...
Motor actions can be facilitated or hindered by psychophysiological states of readiness, to guide rapid adaptive action. Cardiovascular arousal is communicated cardiac signals conveying the timing and strength individual heartbeats. Here, we tested how these interoceptive facilitate control motor impulsivity. Participants performed a stop signal task, in which cues were delivered at different time points within cycle: systole when heart contracts (T-wave peak, approximately 300 ms following...
Generalized anxiety disorder (GAD) is characterized by excessive worry, autonomic dysregulation and functional amygdala dysconnectivity, yet these illness markers have rarely been considered together, nor their interrelationship tested longitudinally. We hypothesized that an individual's capacity for emotion regulation predicts longer-term changes in connectivity, supporting the modification of GAD core symptoms. Sixteen patients with (14 women) individually matched controls were studied at...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting-state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
Fear is coupled to states of physiological arousal. We tested how learning and memory threat, specifically conditioned fear, influenced by interoceptive signals. Forty healthy individuals were exposed two threat (conditioned stimuli [CS+], paired with electrocutaneous shocks) safety (CS-) stimuli, time-locked either cardiac ventricular systole (when arterial baroreceptors signal cardiovascular arousal brainstem), or diastole these afferent signals are quiescent). Threat was indexed...
The cerebellum is known to be a relatively well preserved structure, but subtle alterations may occur early in the evolution of Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) patients appear particularly vulnerable AD. However, little currently whether altered patterns cerebellar function aMCI patients. 26 and 18 well-matched healthy controls underwent baseline resting-state functional magnetic resonance imaging (fMRI) scan. After mean follow-up period 20 months,...
Background Altered hippocampal structure and function is a valuable indicator of possible conversion from amnestic type mild cognitive impairment (aMCI) to Alzheimer's disease (AD). However, little known about the disrupted functional connectivity hippocampus subregional networks in aMCI subjects. Methodology/Principal Findings group-1 (n = 26) controls 18) underwent baseline after approximately 20 months follow up resting-state fMRI scans. Integrity distributed incorporating six subregions...
This paper investigated the effect of voice quality on children's ability to process spoken language. A group 24 children, mean age 11 years 5 months, listened a series recorded short passages, half by female with normal and classic vocal impairment (dysphonic voice). The children were tested for their recall words draw final target inference. Children performed better both preceding indices when listening voice. implications findings are discussed, particular reference classroom situation.
There can be wide variation in the level of oral/aural language ability that prelingually hearing-impaired children develop after cochlear implantation. Automatic perceptual processing mechanisms have come under increasing scrutiny attempts to explain this variation. Using mismatch negativity methods, study explored associations between auditory sensory memory and verbal working function with implants a group hearing controls similar age. Whilst clear relationships were observed activation...
Excessive and uncontrollable worry is a defining feature of Generalized Anxiety Disorder. An important endeavor in the treatment pathological to understand why some people are unable stop worrying once they have started. Worry perseveration associated with tendency deploy goal-directed rules (known as 'as many can' rules; AMA). These require attention goal task continuation until aims 'worry bout' achieved. This study examined association between use AMA neural autonomic responses...
This study analyzed the effects of auditory impairment, age and sex on brainstem response (ABR) wave latencies. ABR I, V I-V interval measures were extracted from clinical records 201 patients with cochlear hearing loss. Females had consistently earlier latencies shorter intervals than males. No observed. Degree impairment a systematic effect intervals. Wave I displayed latency extension increasing levels high-frequency loss, whilst for increases in dependent upon both degree slope...
Recordings of early and late auditory evoked potentials spectral analysis scalp EEGs 14 eight- nine-year-old boys with difficulties in reading, writing spelling were compared those 18 matched controls. The recordings the poor readers lacked normal asymmetry central conduction time wave amplitude (brainstem) potentials, (cortical) potential components reduced amplitude. Spontaneous EEG activity was significantly increased power all bands, this less responsive to changes sensory stimulation....