A5041749806- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Diet and metabolism studies
- Turfgrass Adaptation and Management
- Protein Degradation and Inhibitors
- Nutritional Studies and Diet
- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Inflammation biomarkers and pathways
- Plant Taxonomy and Phylogenetics
- Carbohydrate Chemistry and Synthesis
- Protein Hydrolysis and Bioactive Peptides
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Nutrition, Genetics, and Disease
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Aquaculture Nutrition and Growth
- Protein Kinase Regulation and GTPase Signaling
Wenzhou Medical University
2025
Zhejiang Gongshang University
2025
Quzhou University
2025
Peking University
2015-2023
Shanghai Sixth People's Hospital
2021
Tropical Crops Genetic Resources Institute
2020
Hainan University
2020
Chinese Academy of Tropical Agricultural Sciences
2020
University of Georgia
2020
China National Center for Food Safety Risk Assessment
2013
Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how why this all-or-nothing transition to functionality happens remains unclear. Here, 74 human/hominoid-specific genes, we identified distinctive U1 elements splice-related sequences accounting for nuclear export, differentiating mRNAs lncRNAs, driving the origin of lncRNA loci. The polymorphic sites facilitating lncRNA-mRNA conversion through regulating export...
While some human-specific protein-coding genes have been proposed to originate from ancestral lncRNAs, the transition process remains poorly understood. Here we identified 64 hominoid-specific de novo and report a mechanism for origination of functional proteins lncRNAs with precise splicing structures specific tissue expression profiles. Whole-genome sequencing dozens rhesus macaque animals revealed that these are generally not more selectively constrained than other lncRNA loci. The...
Abstract Japanese encephalitis (JE) caused by virus (JEV) poses a serious threat to the world’s public health yet without cure. Certain JEV-infected neural cells express subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain retain autonomous immunity. However, whether this happens in composited remains unclear. Human pluripotent stem cell (hPSC)-derived organoids can model disorders human endemic pathogens such as Zika virus, which may...
Recent RNA-seq technology revealed thousands of splicing events that are under rapid evolution in primates, whereas the reliability these events, as well their combination on isoform level, have not been adequately addressed due to its limited sequencing length. Here, we performed comparative transcriptome analyses human and rhesus macaque cerebellum using single molecule long-read (Iso-seq) matched RNA-seq. Besides 359 million reads, 4,165,527 Iso-seq reads were generated with a mean length...
Abstract Ca 2+ oscillation is a system-level property of the cellular -handling machinery and encodes diverse physiological pathological signals. The present study tests hypothesis that oscillations play vital role in maintaining stemness liver cancer stem cells (CSCs), which are postulated to be responsible for initiation progression. We found niche factor-stimulated signature feature CSC-enriched Hep-12 purified α2δ1 + CSC fractions from hepatocellular carcinoma cell lines. In cells,...
Recent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general functions these are not well addressed. Here, we perform a comparative editome study human rhesus macaque uncover substantial proportion sites that genomically polymorphic some animals or encoded as non-editable nucleotides human. The occurrence recent gain loss through DNA point mutation is significantly more prevalent than expected for nearby regions. Ancestral state analyses...
Although population genetics studies have significantly accelerated the evolutionary and functional interrogations of genes regulations, limited polymorphism data are available for rhesus macaque, model animal closely related to human. Here, we report first genome-wide effort identify visualize profile in macaque. On basis whole-genome sequencing 31 independent macaque animals, profiled a comprehensive map with 46,146,548 sites. The allele frequency each site, haplotype structure, as well...
Although millions of RNA editing events have been reported to modify hereditary information across the primate transcriptome, evidence for their functional significance remains largely elusive, particularly vast majority sites in noncoding regions. Here, we report a new mechanism functionality editing—a crosstalk with PIWI-interacting (piRNA) biogenesis. Exploiting rhesus macaque as an emerging model organism closely related human, combination extensive genome and transcriptome sequencing...
MicroRNAs are closely associated with the progression and outcomes of multiple human diseases, including sepsis. In this study, we examined role miR-23a in septic injury.Lipopolysaccharide (LPS) was used to induce sepsis a rat model H9C2 HK-2 cells. expression evaluated myocardial kidney tissues, as well A mimic introduced into cells identify cell viability, apoptosis, secretion inflammatory cytokines. Furthermore, effect Rho-associated kinase 1 (ROCK1), target, on damage evaluated,...
Rhesus macaque is a unique nonhuman primate model for human evolutionary and translational study, but the error-prone gene models critically limit its applications. Here, we de novo defined full-length based on single molecule, long-read transcriptome sequencing in four tissues (frontal cortex, cerebellum, heart testis). Overall, 8 588 227 poly(A)-bearing complementary DNA reads with mean length of 14 106 nt were generated to compile backbone transcripts, fine-scale structures further...
Seashore paspalum ( Paspalum vaginatum ) is an important warm-season turfgrass distributed in tropical and coastal areas. It has excellent resistance to abiotic stresses, such as salinity, drought, low temperature. However, the research on genetic diversity of local P. collections from China limited. In this study, among 58 accessions four different provinces cultivars were assessed using simple sequence repeat (SSR) markers. The results indicated that a total 45 alleles detected by 19...
In article number 2003558 by Hongze Liao, Houwen Lin, Yourong Duan, and co-workers, first class of APP/DR6 inhibitor, polymer–peptidomimetic PEG-tAHP-DRI, are developed utilizing three rationaldesigned screening strategies, which demonstrate promising anti-hematogenous metastatic activity inhibiting the binding amyloid precursor protein (APP) death receptor 6 (DR6) as well blocking necroptosis vascular endothelial cells induced tumors cells.