A5058302109- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Chromosomal and Genetic Variations
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Parvovirus B19 Infection Studies
Institute of Molecular Medicine
2024
Peking University
2021-2024
Wuhan University
2020
Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how why this all-or-nothing transition to functionality happens remains unclear. Here, 74 human/hominoid-specific genes, we identified distinctive U1 elements splice-related sequences accounting for nuclear export, differentiating mRNAs lncRNAs, driving the origin of lncRNA loci. The polymorphic sites facilitating lncRNA-mRNA conversion through regulating export...
Quantifying the structural variants (SVs) in nonhuman primates could provide a niche to clarify genetic backgrounds underlying human-specific traits, but such resource is largely lacking. Here, we report an accurate SV map population of 562 rhesus macaques, verified by in-house benchmarks eight macaque genomes with long-read sequencing and another one genome assembly. This indicates stronger selective constrains on inversions at regulatory regions, suggesting strategy for prioritizing them...
Abstract Recent advances in neoantigen research have accelerated the development of immunotherapies for cancers, such as glioblastoma (GBM). Neoantigens resulting from genomic mutations and dysregulated alternative splicing been studied GBM. However, these studies primarily focused on annotated alternatively-spliced transcripts, leaving non-annotated transcripts largely unexplored. Circular ribonucleic acids (circRNAs), abnormally regulated tumors, are correlated with presence linear exon...
Open reading frame (ORF) 45 is an outer tegument protein of Kaposi’s sarcoma-associated herpesvirus (KSHV). Genetic analysis ORF45-null mutant revealed that ORF45 plays a key role in the events leading to release KSHV particles. associates with lipid rafts (LRs), which responsible for colocalization viral particles trans-Golgi network and facilitates their release. In this study, we identified host protein, RAB11 family interacting 5 (RAB11FIP5), interacts vitro vivo . RAB11FIP5 encodes...
Rhesus macaque is a unique nonhuman primate model for human evolutionary and translational study, but the error-prone gene models critically limit its applications. Here, we de novo defined full-length based on single molecule, long-read transcriptome sequencing in four tissues (frontal cortex, cerebellum, heart testis). Overall, 8 588 227 poly(A)-bearing complementary DNA reads with mean length of 14 106 nt were generated to compile backbone transcripts, fine-scale structures further...
Abstract Quantifying the structural variants (SVs) in nonhuman primates could provide a niche to clarify genetic backgrounds underlying human-specific traits, but such resource is largely lacking. Here, we report an accurate SV atlas population of 562 rhesus macaques, verified by two public benchmarks, inhouse benchmark eight macaque genomes with long-read sequencing and another one genome whole-genome assembly. This accurate, quantitative map indicates stronger purifying selection on...