A5101361246- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Hearing Loss and Rehabilitation
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Genetic Associations and Epidemiology
- Wound Healing and Treatments
- Adrenal and Paraganglionic Tumors
- Vector-borne infectious diseases
- Protein Structure and Dynamics
- Synthesis of Organic Compounds
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Melanoma and MAPK Pathways
- Congenital Heart Disease Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Atmospheric Ozone and Climate
- Trace Elements in Health
- Speech and Audio Processing
- Genetic Neurodegenerative Diseases
- Atmospheric chemistry and aerosols
- Cardiovascular Health and Disease Prevention
Nanjing Medical University
2024-2025
Jiangsu Province Hospital
2024-2025
Shandong Provincial Hospital
2024
Shandong University
2024
Qujing Normal University
2024
Ningbo University
2024
Tianjin Medical University General Hospital
2024
Hubei University of Medicine
2024
Ningbo University Affiliated Hospital
2024
Ministry of Ecology and Environment
2024
Background: Tetralogy of Fallot (TOF) is a very common cyanotic congenital heart disease.Endothelial-tomesenchymal transition (EndoMT) recognized as physiological mechanism involved in embryonic development and endothelial formation.However, there still gap the reports related to EndoMT TOF.Methods: First, transcriptomic data single cell nuclei TOF Donor were obtained based on Gene Expression Omnibus (GEO) database, normalized clustered by dimensionality reduction using Seurat...
The oncogene Aurora kinase A (AURKA) has been implicated in various tumor, yet its role meningioma remains unexplored. Recent studies have suggested a potential link between AURKA and ferroptosis, although the underlying mechanisms are unclear. This study presented evidence of upregulation high grade ability to enhance malignant characteristics. We identified as suppressor erastin-induced ferroptosis meningioma. Mechanistically, directly interacted with phosphorylated kelch-like...
The effect of glycemic control on wound healing in patients with diabetic foot ulcers (DFUs) is inconsistent among different studies. This study was performed to investigate the association between level hemoglobin A1c (HbA1c) at baseline as well during treatment and mortality DFU.Hospitalized DFU were recruited consecutively their basic clinical data collected treated according practice guidelines. These followed-up for 1 year observe outcomes, including ulcer death. associations HbA1c or...
Abstract Scrub typhus may be one of the world’s most prevalent, neglected and serious, but easily treatable, febrile diseases. It has become a significant potential threat to public health in China. In this study we used national disease surveillance data analyze incidence spatial–temporal distribution scrub mainland China during 1952–1989 2006–2018. Descriptive epidemiological methods were investigate trends identify high-risk regions infection. Over 51-year period, total 182,991 cases 186...
This study presents an approach using multiple linear regression to quantify the impact of meteorological parameters and chemical species on aerosol pH variance in urban setting Pearl River Delta, China. Additionally, it assesses contributions interactions among these factors pH. The analysis successfully explains over 96% variance, attributing 85.8% original variables 6.7% bivariate interactions, with further 2.3% 1.0% from trivariate quadrivariate respectively. Our results highlight that...
Abstract Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and tumorigenesis. Linear ubiquitin chain assembly complex (LUBAC), the only known ligase capable of catalyzing protein linear ubiquitination to date, implicated in cell signaling associated with cancers. However, role mechanism LUBAC regulating expression function HIF1α, labile subunit HIF1, remain be elucidated. Herein we showed that increases HIF1α cultured cells tissues human lung cancer enhances...
Molecular property prediction is an important task in drug discovery, and with help of self-supervised learning methods, the performance molecular could be improved by utilizing large-scale unlabeled dataset. In this paper, we propose a triple generative method for prediction, called TGSS. Three encoders including bi-directional long short-term memory recurrent neural network (BiLSTM), Transformer, graph attention (GAT) are used pre-training model using sequence structure data to extract...
Abstract Background Cutaneous melanoma (CM) has an overall poor prognosis due to a high rate of metastasis. This study aimed explore the role hypoxia-related genes (HRGs) in CM. Methods We first used on-negative matrix factorization consensus clustering (NMF) cluster CM samples and preliminarily analyzed relationship HRGs immune cell infiltration. Subsequently, we identified prognostic-related hub by univariate COX regression analysis least absolute shrinkage selection operator (LASSO)...
Acute morphological changes in de novo coronary lesions after drug-coated balloon (DCB) angioplasty can affect endothelial mechanics and consequently clinical outcomes. Angiography-based computational modeling has been validated to assess dynamic strain (EDS) arteries vivo. The EDS was calculated on the basis of pre- post-DCB angiography. Parameters quantitative angiography were quantified at cross-sections treated segments. A total 336 348 lesion included small/large vessel groups,...
A proteomic analysis was performed to compare protein expression between normal sternocleidomastoid muscle and denervated muscle. Two-dimensional electrophoresis (2-DE) of proteins showed that 26 among about 800 spots in 2-DE gel displayed a decrease 6 an increase muscles with denervation atrophy compared controls; the identified were abnormally expressed could be generally grouped together as metabolic proteins, chaperone contractile-apparatus proteins. The significance these altered is...
Abstract Background and Aims : Increasing evidences suggest that nonalcoholic fatty liver disease is associated with neuropsychiatric disorders. Nevertheless, whether there were causal associations between them remained vague. A association disorders NAFLD was investigated in this study. Methods We assessed the published genome-wide study summary statistics for NAFLD, seven mental disorder-related diseases five central nervous system dysfunction-related diseases. The relationship first using...
Objective Clinical characteristics of the infection in diabetic foot ulcers (DFU) were analyzed regard to severity and related prognosis.Methods The data from 506 hospitalized patients with DFU collected,the rates healed ulcer,amputation,and mortality followed for 1 year.These divided into different groups according grades ulcer infection.Statistics was made find their clinical association outcomes.Results rate 95.8％.Within one year,80.6％ had cured,23.3％ them underwent amputation toes or...
Objective: To explore the correlation between TCM syndrome types and quantitative brain MRI scores in patients with Wilson's disease (WD). Methods: Eighty diseae who visited First Affiliated Hospital of Anhui University Chinese Medicine from February 2021 to 2023 were selected subjected evidence-based typing, 24h urine copper test, cranial examination, abnormal signals quantified scored. The different score was studied by variance analysis binary logistic regression analysis. Results: onset...
Fundamental frequency (F0) cues to voice/musical pitch can be coded by pulse-rate or amplitude modulation (AM) rate of electrical pulse-trains in cochlear implant (CI) systems. However, for most clinical strategies (e.g., ACE), temporal F0 are often poorly coded, particularly female and children's voices and/or background noise. Strategies such as Optimized Pitch And Language (OPAL) Asynchronous Stimulus Timing (FAST) enhance cues. For OPAL, is estimated used control the AM channel...