A5101775410- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mitochondrial Function and Pathology
- Renal Diseases and Glomerulopathies
- Metabolomics and Mass Spectrometry Studies
- Cell death mechanisms and regulation
- Bioinformatics and Genomic Networks
- ATP Synthase and ATPases Research
- Gut microbiota and health
- Congenital heart defects research
- Cancer, Hypoxia, and Metabolism
- Curcumin's Biomedical Applications
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Platelet Disorders and Treatments
- Ion channel regulation and function
- Monoclonal and Polyclonal Antibodies Research
- Protein Kinase Regulation and GTPase Signaling
- Cardiac electrophysiology and arrhythmias
- Cancer Research and Treatments
- Chronic Lymphocytic Leukemia Research
- IgG4-Related and Inflammatory Diseases
- Plant tissue culture and regeneration
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
Nanjing University
2020-2024
Second Affiliated Hospital of Xinjiang Medical University
2023-2024
Nanjing General Hospital of Nanjing Military Command
2020-2024
Xinjiang Medical University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Nanjing Medical University
2020-2022
Shanghai Sixth People's Hospital
2018-2021
Shanghai Jiao Tong University
2018-2021
Guangxi Medical University
2018-2020
Abstract Background Acute pulmonary embolism (APE) remains a diagnostic challenge due to variable clinical presentation and the lack of reliable screening tool. MicroRNAs (miRNAs) regulate gene expression in wide range pathophysiologic processes. Circulating miRNAs are emerging biomarkers heart failure, type 2 diabetes other disease states; however, using plasma as for diagnosis APE is still unknown. Methods Thirty-two patients, 32 healthy controls, 22 non-APE patients (reported dyspnea,...
Acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) have been the leading cause of morbidity mortality in intensive care units (ICU). Currently, there is no effective pharmacological treatment for injury. Curcumin, extracted from turmeric, exhibits broad anti-inflammatory properties through down-regulating inflammatory cytokines. However, instability curcumin limits clinical application.A series new analogs were synthesized screened their inhibitory...
Mitochondrial retrograde regulation (MRR) is the transduction of mitochondrial signals to mediate nuclear gene expression. It not clear whether MRR a common mechanism in plant abiotic stress response. In this study, we analysed early response rice OsAOX1 genes, and induction OsAOX1a OsAOX1b (OsAOX1a/b) was selected as working model for stress-induced studies. We found that mediated by superoxide ion (O2·(-) )-generating chemical methyl viologen stronger than hydrogen peroxide (H2 O2 ). The...
Cold-inducible RNA-binding protein (CIRP) is constitutively expressed at low levels across various tissues. It rapidly upregulated by multiple stresses, underlying a general role for CIRP in organic adaptations to pathophysiological conditions. However, the of heart remains unclear.To examine biofunctions mammalian heart.Rats with targeted disruption Cirp were generated using TALEN (transcription activator-like effector nucleases)-based genome editing technique. The Cirp-knockout rats had...
Abstract Background Metabolomics data analyses rely on the use of bioinformatics tools. Many integrated multi-functional tools have been developed for untargeted metabolomics processing and widely used. More alternative platforms are expected both basic advanced users. Results Integrated mass spectrometry-based mining (IP4M) software was designed developed. The IP4M, has 62 functions categorized into 8 modules, covering all steps mining, including raw preprocessing (alignment, peak...
Obesity is strongly associated with the cause of structural and functional changes heart in both human animal models. Oxidative stress inflammation play a critical role development obesity-induced cardiac disorders. Curcumin natural product from Curcuma Longa multiple bioactivities. In our previous study, order to reach better anti-inflammatory anti-oxidant dual activities, we designed new mono-carbonyl curcumin analog, Y20, via modification trifluoromethyl bromine. This study was...
Abstract Low-density lipoprotein receptor-related protein 6 (LRP6) is a Wnt co-receptor in the canonical Wnt/β-catenin signalling. Here, we report scaffold function of LRP6 gap junction formation cardiomyocytes. Cardiac spatially restricted to intercalated discs and binds connexin 43 (Cx43). A deficiency disrupts Cx43 thereby impairs cell-to-cell coupling, which independent The defect resulting from reduction attributable defective traffic de novo proteins endoplasmic reticulum Golgi...
Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed synthesized. Compound 4a is the first organic micromolecule to kill tumor cells by only paraptosis, its mechanism of action has been further explored. Paraptosis does not appear involve either phosphatidylserine translocation associated with apoptosis or cycle arrest. The bisbenzyloxy N-(2-hydroxyethyl)formamide structures may be two critical pharmacophores for paraptosis. Bisbenzyloxy can...
β-Adrenoceptors (β-ARs) play a critical role in the regulation of cardiovascular function. Intracellular oxygen homeostasis is crucial for survival cardiomyocytes. However, it still unclear whether β-AR activation can modulate intracellular oxygen. Here we used mitochondrial and cytosolic target Renilla luciferase to detect concentration. Pharmacological experiments revealed that β2-AR specifically regulates cardiomyocytes COS7 cells. This effect was abrogated by inhibitory G protein (Gi)...
Circular RNAs (circRNAs) are non-coding forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In present study, four left appendages (LAA) patients with NPAF normal LAAs were examined via sequencing, functions investigated bioinformatics analysis. The circRNA‑enriched genes analyzed...
microRNAs (miRNAs) play essential roles in cardiogenesis. The altered expression of miRNAs can result cardiac malformations by inducing abnormalities the behavior cells. However, role miR-10a regulation cardiomyocyte progenitor cells (CMPCs) remains undetermined. In present study, we found that up- or down-regulation inhibited promoted proliferation human CMPCs, respectively, without affecting their differentiation toward cardiomyocytes. bound to GATA6 directly and reduced expression....
Gene transformation is an important method for improvement of plants into elite varieties. However, the possibility gene flow between genetically modified (GM) crops and similar species a serious public issue that may potentially endanger ecological stability. Cleistogamy expected to be ideal genetic tool preventing transgene propagation from GM crops. A rice mutant, cl7(t), was created by ethyl methanesulfonate mutagenesis. The mutant exhibited cleistogamy, had closed spikelets, reduced...
Objective- Mitochondria are the important yet most underutilized target for cardio-cerebrovascular function integrity and disorders. The Tom (translocases of outer membrane) complex critical determinant mitochondrial homeostasis making organs acclimate physiological pathological insults; however, their roles in vascular system remain unknown. Approach Results- A combination studies vascular-specific transgenic zebrafish genetically engineered mice was conducted. Vascular casting imaging,...
Aim: The EGF receptor (EGFR) is overexpressed in multiple epithelial-derived cancers and considered to be a vital target closely associated with cancer therapy. In this study, series of novel anthraquinone−quinazoline hybrids targeting several sites for therapy were designed synthesized. Methodology & results: Most the synthesized demonstrated excellent antiproliferative activity downregulation expression EGFR. most promising compound 7d showed strongest antiproliferation activity;...
Sarcolemmal Na(+) /H(+) exchanger 1 (NHE1) activity is essential for the intracellular pH (pHi ) homeostasis in cardiac myocytes. Emerging evidence indicates that sarcolemmal NHE1 dysfunction was closely related to cardiomyocyte death, but it remains unclear whether defective trafficking of plays a role vital cellular signalling processes. Dynamin (DNM), large guanosine triphosphatase (GTPase), best known its roles membrane events. Herein, using co-immunoprecipitation, cell surface...