A5100381765- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Medical Research and Treatments
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Chromatography in Natural Products
- Acupuncture Treatment Research Studies
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- Phytochemistry and Biological Activities
- Healthcare and Venom Research
- Cancer, Lipids, and Metabolism
- Flavonoids in Medical Research
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Aluminum Alloys Composites Properties
- RNA modifications and cancer
- Medicinal Plants and Neuroprotection
Shanghai Jiao Tong University
2016-2025
Tianjin University of Traditional Chinese Medicine
2018-2025
First Affiliated Hospital of Henan University
2021-2025
Zhejiang University
2020-2025
Children's Hospital of Zhejiang University
2025
Yunnan Academy of Agricultural Sciences
2024
Nanfang Hospital
2009-2024
Southern Medical University
2009-2024
Taizhou University
2024
Ruijin Hospital
2023-2024
Hepatocellular carcinoma (HCC) is a common malignancy in the world with high morbidity and mortality rate. Identification of novel biomarkers HCC remains impeded primarily because heterogeneity disease clinical presentations as well pathophysiological variations derived from underlying conditions such cirrhosis steatohepatitis. The aim this study to search for potential metabolite human using serum urine metabolomics approach. Sera samples were collected patients (n = 82), benign liver tumor...
Chronic stress is closely linked to clinical depression, which could be assessed by a chronic unpredictable mild (CUMS) animal model. We present here GC/MS‐based metabolic profiling approach investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues. Multi‐criteria assessment for multivariate statistics identify differential metabolites between CUMS‐model rats versus healthy controls. This study demonstrates that significantly perturbed...
Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate protein stability, altered ratios T58 S62 have been observed in human cancer. Here, we report development 3 unique c-myc knock-in mice conditionally express either c-Myc(WT) or c-Myc(T58A) c-Myc(S62A) mutant from constitutively active ROSA26 locus response Cre recombinase study role these vivo. Using a mammary-specific model, found expression...
The pathological development and the drug intervention of type 2 diabetes mellitus (T2DM) involve altered expression downstream low molecular weight metabolites including lipids amino acids, carbohydrates such as glucose. Currently, a small number markers used for clinical assessment T2DM treatment may be insufficient to reflect global variations in pathophysiology. In this study, metabonomic study was performed determine metabolic associated with treatments on 74 patients who were newly...
Gastric cardia cancer (GCC), which occurs at the gastric-esophageal boundary, is one of most malignant tumors. Despite its high mortality and morbidity, molecular mechanism initiation progression this disease largely unknown. In study, using proteomics metabolomics approaches, we found that level several enzymes their related metabolic intermediates involved in glucose metabolism were deregulated GCC. Among these enzymes, two subunits controlling pyruvic acid efflux, lactate dehydrogenase A...
The Myc oncoprotein is considered a master regulator of gene transcription by virtue its ability to modulate the expression large percentage all genes. However, mechanisms that direct Myc's recruitment DNA and target selection elicit specific cellular functions have not been well elucidated. Here, we report Pin1 prolyl isomerase enhances serine 62-phosphorylated coactivators select promoters during activation, followed promoting release associated with degradation. This facilitates...
Radio- and photodynamic therapies are the first line of cancer treatments but suffer from poor light penetration less radiation accumulation in soft tissues with high toxicity. Therefore, a multifunctional nanoplatform diagnosis-assisted synergistic radio- therapy tools facilitating early prognosis urgently needed to fight war against cancer. Further, integrating untargeted metabolomic analysis would collectively offer clinical pertinence through diagnosis prognosis. Here, we enriched...
INTRODUCTION: Elevated liver enzyme levels are observed in patients with coronavirus disease 2019 (COVID-19); however, these features have not been characterized. METHODS: Hospitalized COVID-19 Zhejiang Province, China, from January 17 to February 12, 2020, were enrolled. Liver level elevation was defined as alanine aminotransferase >35 U/L for men and 25 women at admission. Patients normal included the control group. Reverse transcription polymerase chain reaction used confirm severe...
The use of diversified ginseng extracts in health-promoting foods is difficult to differentiate, as they share bioactive ginsenosides among different Panax species (e.g., P. ginseng, quinquefolius, notoginseng, and japonicus) parts root, leaf, flower). This work was designed develop a pseudo-targeted metabolomics approach discover ginsenoside markers facilitating the precise authentication its compound formulation products (CFPs). Versatile mass spectrometry experiments on QTrap spectrometer...
Vol.10 (2011) 1–13 DOI:10.1074/mcp.A110.004945 Legends for figures 2 and 3 have been revised along with abbreviation HCC; hepatocellular carcinoma. The online version of this article reflects these changes.
The flower buds of three Panax species (PGF: bud P. ginseng; PQF: quinquefolius; PNF: notoginseng), widely consumed as healthcare products, are easily confused particularly in the extracts or traditional Chinese medicine (TCM) formulae. We aimed to develop an untargeted metabolomics approach, by ultra-high performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) unveil chemical markers diagnostic for differentiation PGF, PQF, and PNF. Key...
Biomarker of insulin resistance, namely triglyceride-glucose index, is potentially useful in identifying critically ill patients at high risk hospital death. However, the TyG index might have variations over time during ICU stay. Hence, purpose current research was to verify associations between dynamic change stay and all-cause mortality.The present retrospective cohort study conducted using Medical Information Mart for Intensive Care IV 2.0 (MIMIC-IV) critical care dataset, which included...
The Microbiome Protocols eBook (MPB) serves as a crucial bridge, filling gaps in microbiome protocols for both wet experiments and data analysis. first edition, launched 2020, featured 152 meticulously curated protocols, garnering widespread acclaim. We now extend sincere invitation to researchers participate the upcoming 2nd version of MPB, contributing their valuable advance research. is research area that focuses on studying omics microbe [1] with rapid development past few decades,...
Rodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone, OP), others not obesity-resistant, OR). Transcriptomic metabonomic profiling OP OR rats has been conducted, showing sets significantly different phenotypic profiles response 16 weeks diet. We observed significant differences transcriptional expression nearly 80 genes, which are known be involved lipid metabolism, transport, ketone production. The...
Abstract The bacterial diversity in fecal samples from the wild pygmy loris was examined with a 16S rDNA clone library and restriction fragment length polymorphism analysis. clones were classified as Firmicutes (43.1%), Proteobacteria (34.5%), Actinobacteria (5.2%), Bacteroidetes (17.2%). 58 different kinds of sequences into 16 genera 20 uncultured bacteria. According to phylogenetic analysis, major within Pseudomonas , comprising 13.79% analyzed sequences. Many isolated did not correspond...
To evaluate the efficacy of a functional microarray microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women China. Thirty female subjects with were enrolled this study. The left or right side face was chosen randomly to be pretreated MNs, followed by 0.5% TA solution once per week 12 weeks. other half-face control, treated sham device solution. At baseline and at weeks 4, 8, treatment, clinical (photographic) evaluations parameters determined Visia recorded. 12,...
Ginseng, a widely used functional food and additive, has been proven to have promotion effects of health on the body. However, whether long-term intake Ginseng is beneficial or side an organism still unclear. In this study, untargeted GC-TOFMS metabolomic analysis serum, cecum ileum intestinal contents was conducted understand effect extracts. 16S rRNA microbial sequencing technology applied investigate extracts structure gut microbiota. Cytokines in spleen were detected determine immune...
Evidence has suggested a potential link exists between trimethylamine-N-oxide (TMAO), choline-derived metabolite produced by gut microbiota, and some cancers, but little is known for primary liver cancer (PLC). A case-control study was designed including 671 newly diagnosed PLC patients control subjects frequency-matched age (±5 years) sex, in Guangdong province, China. High-performance liquid chromatography with online electrospray ionization tandem mass spectrometry (HPLC-MS/MS) used to...