A5101590422- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Reconstructive Surgery and Microvascular Techniques
- CAR-T cell therapy research
- Multiple and Secondary Primary Cancers
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- RNA regulation and disease
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Racial and Ethnic Identity Research
- Immune Cell Function and Interaction
- Cultural Differences and Values
- Demographic Trends and Gender Preferences
- Flood Risk Assessment and Management
- Hydrology and Drought Analysis
- Colorectal and Anal Carcinomas
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Bioactive Natural Diterpenoids Research
- Cancer-related molecular mechanisms research
- Cutaneous lymphoproliferative disorders research
- CRISPR and Genetic Engineering
- Mental Health Treatment and Access
Children's Hospital of Zhejiang University
2024-2025
Zunyi Medical University
2024
Xuzhou Medical College
2018-2021
82th Hospital of Pla
2014
Sohu (China)
2008
Mayo Clinic
2004
Previous studies revealed that leptin induces the growth and proliferation inhibits apoptosis of lung cancer cells. However, effect on epithelial-to-mesenchymal transition (EMT) is not yet clear. In present study, EMT was investigated as well its underlying mechanisms in A549 The ability to induce by microscopic examination western blotting. impacts cell migration, invasion tumorigenesis were evaluated wound healing, Transwell colony formation assays, respectively. It demonstrated induced...
Abstract Matrix metalloproteinases (MMPs) play a crucial role in tumor cell invasion and metastasis. Expression of MMP‐1 has been reported as prognostic predictor recurrence human chondrosarcoma, studies using chondrosarcoma lines indicate that expression levels correlate with vitro invasiveness. These observations suggest activity central egress from the primary at an early step metastatic cascade. In this study, siRNA was used to investigate whether knock down gene could be inhibit...
Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast prognosis, but role in colorectal metastasis (CRPM) remains unknown.The expression profiles were analyzed CRC with or without CRPM cell lines increasing metastatic potential. Overexpression short hairpin RNA knockdown assays performed cells, the effects these alterations on epithelial-mesenchymal transition...
Currently, cytokine therapy for cancer has demonstrated efficacy in certain diseases but is generally accompanied by severe toxicity. The field of antibody-cytokine fusion proteins (immunocytokines) arose to target these effector molecules the tumor microenvironment expand therapeutic window therapy. Therefore, we have developed a novel immunocytokine that binds specifically programmed death 1 (PD1) and fuses IL15/IL15Rα complex (referred as IAP0971) immunotherapy.We report here making...
IAH0968 is an afucosylated anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody which improved the activity of antibody-dependent cellular cytotoxicity (ADCC) and superior anti-tumor efficacy.
Abstract Due to limited data, the spatial characteristics and connectivity of urban floods in eastern China remain poorly understood. In this study, we established a new data set during 2010–2020, compiled from multiple sources. Based on set, our analysis identified four high‐frequency flood centers South, Southeast, Southwest, North China. Distinct regional differences are revealed for regions south north, with monthly peaks shifting May August precipitation thresholds decreasing high low....
<title>Abstract</title> Locally recurrent rectal cancer (LRRC) refers to the lesions that appear in pelvic cavity and perineum with same pathological type as primary tumor after radical operation of cancer, excluding other distant metastases such liver, lung, bone. Radical surgical resection patients is a central element improving quality life survival. In this paper, we report case patient who was admitted our hospital recurrence ulcerated moderately differentiated carcinoma lower rectum...
<title>Abstract</title> ATPase family AAA-domain-containing protein 3A (ATAD3A) is enriched on the mitochondrial membrane and essential to maintenance of structure function. Variants ATAD3A gene can lead Harel-Yoon syndrome (HAYOS), a developmental defect in neurological, cardiovascular, other systems. This study aims develop induced pluripotent stem cells (iPSCs) from somatic patient (ZJUCHYLi001-A) negative control (ZJUCHYLi002-A) as effective tools for further investigations into etiology...
Background: This retrospective study aimed to identify key factors affecting the rate of complete resection for non-metastatic rectal neuroendocrine tumors (NETs) using both transanal local excision (TLE) and endoscopic submucosal dissection (ESD). Methods: Records in past 10 years were retrieved, a total 95 patients diagnosed with NETs sized between 10-20 mm. Treatment outcomes first compared TLE ESD significantly associated factors. Monofactor analysis was then performed resections risk...
Objective To investigate effect of autologous periosteum transplantation in the repair anterior cruciate ligament (ACL) injury. Methods Transected ACL injury was induced 24 white rabbits randomly allocated to receive with suture fixation (study group, n=12), isolated (control and arthrotomy (blank n=3). Gross observation performed degeneration knee joint evaluated using Markin score. pathology, collagen fiber formation insertion degenerative changes were histologically investigated HE...
Abstract Background and Significance Biological therapies harnessing the adaptive immune system have achieved a great success, given clinical efficacy of CAR-T CD3 based T cell engagers in treating hematologic tumors, application checkpoint inhibitors various indications. However, challenges still exist due to limitation solid tumors. Side effects such as cytokine release storm neurotoxicity remain concern selection CD3-based therapeutics. For PD1/L1-based immunotherapy, relatively low...
Objective To explore the effects of preoperative neoadjuvant endocrine therapy on expression and significance ER, PR, C-erbB-2 in pestmenopause breast cancer patients over 60 years old. Methods 36 were treated with endrocrine by oral tamoxifen for ～ 90 days, PR was examined before after therapy. Results In negative expres-sion rate 16.78% 11.11% respectively therapy, compared to 50% 33.33% There significant difference(P<0.05). The 13.8% 16.67% there no difference between two figures....
疼痛7个月于2006年1月20日入院.患者于7个月前无明显诱因于臀部出现黄豆大小红色结节,触之较硬,不高出皮肤,伴轻微疼痛,无发热及关节疼痛.在当地医院诊断为结节性脂膜炎,给予地塞米松等药物治疗,皮疹部分消退,遗留色素沉着,但仍有新的皮疹反复出现,且逐渐增多增大,部分皮疹中央出现坏死、结痂。
Objective To explore the expression of HR and Her-2 in breast cancer primary tumor axillary lymph node metastasis. Methods Four hundred twenty-eight female patients with unilateral combined metastasis treated Affiliated Suqian Hospital Xuzhou Medical University from January 2011 to 2016 were selected this study.Immunohistochemistry was used detect ER, PR, Ki67 metastasis. Results The positive rates ER 75.9% (325/428) 70.3% (301/428) respectively metastasis.The PR 61.4% (263/428)...
Objective To explore the application of paclitaxel or docetaxel combined with cisplatin (TP) cyclophosphamide, pirirubicin and fluorouracil (FAC) in primary tumor molecular typing Luminal A, axillary lymph node metastasis three negative breast cancer. Methods From January 2012 to 2014, clinical data forty-nine patients were selected.All divided into two groups by balance randomization method, TP group FAC group.Twenty-five treated regimen 24 regimen.The efficacy was evaluated after...