In this work, unmodified carbon nanodots are demonstrated as novel and environmentally-friendly fluorescence probes for the sensing of Hg2+ biothiols with high sensitivity selectivity.

A synergistic graphene oxide-gold nanocluster (GO-AuNC) hybrid has been constructed as an enzyme mimic that is able to show high catalytic activity over a broad pH range, especially at neutral pH. Importantly, the target-functionalized applied robust nanoprobe for selective, quantitative, and fast colorimetric detection of cancer cells.

A novel proton-fueled molecular gate-like delivery system has been constructed for controlled cargo release using i-motif quadruplex DNA as caps onto pore outlets of mesoporous silica nanoparticles.Start from simple conformation changes, the cap can open and close in smart response to pH stimulus.Importantly, opening/closing protocol is highly reversible a partial be easily at will.A pH-switchable nanoreactor also developed validate potential our on-demand transport.This proof concept might...

A new type of rapid, highly sensitive, and selective fluorescence turn-on assay for detection cysteine histidine using a DNA/ligand/ion ensemble is developed. This based on the specific interaction between amino acids metal ions strong thiazole orange (TO)/DNA probe in competition format. The resulting high sensitivity selectivity was achieved by changing ions. system simple design fast operation more convenient promising than other methods. novel strategy eliminated need organic cosolvents,...

Herein, for the first time, we report copper-cysteamine (Cu-Cy) nanoparticles having Cu1+ instead of Cu2+ as an efficient heterogeneous Fenton-like catalyst highly selective cancer treatment. Initial measurements Cu-Cy's hydroxyl radical generation ability show that it behaves a reagent in presence H2O2 (100 μM) at pH 7.4, and its activity is dramatically enhanced under acidic conditions (pH 6.5 5.5). Notably, Cu-Cy exhibits high stability minimal copper release during reaction,...

Oil pollution has always been an important issue affecting the ecological and residential environment, development of a highly efficient oil/water separation membrane become hot topic. In this paper, Janus polyacrylonitrile (PAN) nanofiber membranes (PNM) were prepared by co-blending hydrophilic SiO2 nanoparticles, carbon nanotubes (CNTs) doped with PAN (PNM-SiO2 PNM-CNT, respectively) then using sequential multilayer electrospinning. The existence electrostatic mutual gravitational force...

Abstract Uncontrolled hemorrhage is still the most common cause of potentially preventable death after trauma in prehospital settings. However, there rarely are hemostatic materials that can achieve safely and efficiently rapid hemostasis simultaneously. Here, new carbonized cellulose‐based aerogel material developed for management noncompressible torso hemorrhage, intractable issue uncontrolled hemorrhage. The cellulose derived from Agaricus bisporus a series processing, including cutting,...

Electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) is a promising approach to produce high-value chemicals such as 2,5-furandicarboxylic acid (FDCA). However, the undesirable stability catalysts commonly limits its potential application value. In this work, NiOOH derived from Ni(OH)2 was determined main catalytic site for HMF oxidation, but collapse caused severe instability during electrocatalytic process because crystal structure mismatch between and Ni(OH)2. The...

Bacterial infection and scar formation remain primary challenges in wound healing. To address these issues, we developed a decellularized pomelo peel (DPP) functionalized with an adhesive PVA-TSPBA hydrogel antibacterial gallic acid/copper MOFs. The hybrid dressing demonstrates favorable biocompatibility. It does not impede the proliferation of fibroblasts or immune cells can stimulate fibroblast migration, endothelial angiogenesis, M2 macrophage polarization. Additionally, scavenge reactive...

Electrocatalytic nitrate reduction reaction (EC-NITRR) shows a significant advantage for green reuse of the (NO3–) pollutant. However, slow diffusion limits rate in practical EC-NITRR, causing an unsatisfactory ammonia (NH3) yield. In this work, multifunctional NiFe-LDH/CeO2 with dual adsorption effect (physisorption and chemisorption) dual-metal sites (Ce3+ Fe2+) was fabricated by electrodeposition method. performed expected ability enrichment NO3– through pseudo-first-order...

We demonstrate a novel concept for the construction of label-free, quadruplex-based functional molecular beacon (LFG4-MB) by using G-quadruplex motif as substitute Watson-Crick base pairing in MB stem and specific binder, N-methyl mesoporphyrin IX (NMM) reporter. It shows high sensitivity assays UDG activity/inhibition detection DNA sequence based on unique fluorescence increase that occurs result strong interaction between NMM folded quadruplex upon removal uracil or displacement block...

A novel multifunctional, proton-fueled DNA nano-spring has been constructed. By incorporation of the G-quadruplex/i-motif sequence into assembly, nanodevice can perform spring-like motions in response to changes environmental pH without permanent deformation. Nanosized objects/functional groups could be assembled/disassembled this system an addressable, contractile, and reversible manner. For over 20 years, recognized as attractive building material nanotechnology materials science owing its...

Abstract Precise organization of metallic nanoclusters on DNA scaffolds holds great interest for nanopatterned materials that may find uses in electronics, sensors, medicine, and many other fields. Herein, we report the site‐specific growth fluorescent silver by using a mismatched double‐stranded template. Few‐atom, molecular‐scale Ag clusters are found to localize at site metallized retains its integrity. The DNA‐encapsulated can be utilized as functional biological probes identify single‐...

A new strategy to create site-specific, homogeneous, and bright silver nanoclusters (AgNCs) with high-stability was demonstrated by triplex DNA as template. By reasonable design of sequence, homogeneous Ag2 cluster obtained in the predefined position CG.C+ site DNA. This also explored for controlled alignment AgNCs on nanoscaffold. To best our knowledge, this first example simultaneously answer challenges excellent site-specific nucleation growth, homogeneity stability against salt...

In this study, we develop an efficient method for multiple DNA detection by exploring silver nanoclusters (AgNCs)–graphene oxide (GO) nanohybrid materials. Because of the extraordinarily high quenching efficiency GO, ssDNA–AgNCs probe exhibits minimal background fluorescence, while strong emission is observed when it forms a double helix with specific target DNA, leading to signal-to-background ratio. Therefore AgNCs–GO materials can be successfully applied detection. The system described...

Abstract Background: Up-regulation of CX3CL1 has been revealed to be involved in the neuropathic pain induced by nerve injury. However, whether participates paclitaxel-induced painful peripheral neuropathy remains unknown. The aim current study was elucidate involvement transcriptional factors nuclear factor-κB (NF-κB) and its causal interaction with signaling neuropathy. Methods: Painful paclitaxel treatment established adult male Sprague-Dawley rats. von Frey test were performed evaluate...

Bacterial infection and scar formation remain primary challenges in wound healing. To address these issues, we developed a decellularized pomelo peel (DPP) functionalized with an adhesive PVA-TSPBA hydrogel antibacterial gallic acid/copper MOFs. The hybrid dressing demonstrates favorable biocompatibility. It does not impede the proliferation of fibroblasts or immune cells can stimulate fibroblast migration, endothelial angiogenesis, M2 macrophage polarization. Additionally, scavenge reactive...

Herein, a fluorometric and colorimetric dual-mode assay platform used for α-glucosidase (α-Glu) activity sensing based on aggregation-induced emission enhancement (AIEE) of AuNCs was developed the first time. The quantum yield (QY) fluorescence lifetime were successfully ameliorated by Ce