A5078071191- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Heavy Metals in Plants
- Nephrotoxicity and Medicinal Plants
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Ginseng Biological Effects and Applications
- Estrogen and related hormone effects
- Geochemistry and Geologic Mapping
- Geological and Geochemical Analysis
- Educational Reforms and Innovations
- Innovative Educational Techniques
- Pharmaceutical and Antibiotic Environmental Impacts
- Trace Elements in Health
- Bacterial biofilms and quorum sensing
- Education and Work Dynamics
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Nerve Injury and Rehabilitation
- Inflammatory mediators and NSAID effects
- Medical Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Osteoarthritis Treatment and Mechanisms
- Pain Mechanisms and Treatments
- Chemokine receptors and signaling
Chongqing Institute of Geology and Mineral Resources
2023-2024
Peking University First Hospital
2017-2024
Peking University
2017-2024
Ludong University
2008-2024
Chengde Medical University
2024
Shandong University
2012-2023
Shandong First Medical University
2023
People's Liberation Army 401 Hospital
2023
Shandong Provincial Hospital
2023
Qilu Hospital of Shandong University
2015-2022
While to date investigations provided convincing evidence on the role of aristolochic acids (AAs) in etiology Balkan endemic nephropathy (BEN) and upper urothelial cancer (UUC), exposure pathways by which AAs enter human bodies cause BEN UUC remain obscure. The goal this study is test hypothesis that environmental pollution root uptake polluted soil may be one food chain. driving was decay Aristolochia clematitis L., a AA-containing herbaceous plant found growing widespread regions, could...
Inherent complexity of plant metabolites necessitates the use multi-dimensional information to accomplish comprehensive profiling and confirmative identification. A dimension-enhanced strategy, by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (2D-LC/IM-QTOF-MS) enabling four-dimensional separations (2D-LC, IM, MS), is proposed. In combination with in-house database-driven automated peak annotation, this strategy was utilized...
Osteoarthritis (OA) is a common degenerative disease, and tumor necrosis factor (TNF-α) known to play critical role in OA. Cortistatin (CST) neuropeptide discovered over 20 years ago, which plays vital inflammatory reactions. However, it unknown whether CST involved cartilage degeneration OA development.The interaction between TNF-α receptors was investigated through Coimmunoprecipitation Biotin-based solid-phase binding assay. Western blot, Real-time PCR, ELISA, immunofluorescence staining,...
The flower buds of three Panax species (PGF: bud P. ginseng; PQF: quinquefolius; PNF: notoginseng), widely consumed as healthcare products, are easily confused particularly in the extracts or traditional Chinese medicine (TCM) formulae. We aimed to develop an untargeted metabolomics approach, by ultra-high performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) unveil chemical markers diagnostic for differentiation PGF, PQF, and PNF. Key...
Emerging evidence has suggested aristolochic acids (AAs) are linked to the development of Balkan endemic nephropathy (BEN), a chronic renal disease affecting numerous farmers living in peninsula. However, pathway by which AAs enter human food chain and cause kidney remains poorly understood. Using our previously developed analytical method with high sensitivity selectivity (Chan, W.; Lee, K. C.; Liu, N.; Cai, Z. J. Chromatogr. A 2007, 1164, 113-119), we quantified lettuce, tomato, spring...
Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Anemarrhena asphodeloides and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, present study aimed examine protective efficacy of JTD in DN elucidate underlying molecular mechanisms.A model using KK-Ay mice received daily...
Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence BEN on Peninsula assumed result consumption clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants enter wheat maize by root uptake strong pH dependence. Soil crops Serbian farms in areas for A. were found be extensively contaminated AAs,...
Genomic islands (GIs) play an important role in the chromosome diversity of Enterococcus. In current study, we aimed to investigate spread GIs between Enterococcus strains and their correlation with antibiotic resistance genes (ARGs). Bitsliced Signature Indexes (BIGSI) were used screen NCBI Sequence Read Archive (SRA) for multiple resistant A total 37 pairs raw reads screened from 457,000 whole-genome sequences (WGS) SRA database, which come Enterococci distributed eight countries. These...
Despite Panax notoginseng (Sanchi: the root and rhizome) is globally popular serving as source of food additives, health-care products, traditional Chinese medicines (TCMs), saponin difference between (PNR) two aerial parts (leaf, PNL; flower bud, PNF) that can be vicariously used, remains unclear. Authentication Sanchi, particular from patent (CPMs), poses great challenges. Ultra-high performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry...
Psoriasis is a complex autoimmune disease that closely associated with the disorganized pro-inflammatory polarization of macrophages and activation inflammatory signalling pathways. Nanoparticles (NPs) have shown their potential in immune response regulation related treatment diseases. Herein, we report modulation skin system for amelioration psoriasis-like inflammation using mung bean-derived NPs (MBNs), which exhibit high antioxidant activity to reduce reactive oxygen species (ROS)...
The aim was to develop and validate a nomogram for the prediction of brain metastases (BM) in small cell lung cancer (SCLC), explore risk factors assist clinical decision-making.We reviewed data SCLC patients between 2015 2021. Patients 2019 were included develop, whereas 2020 2021 used external validation. Clinical indices analysed by using least absolute shrinkage selection operator (LASSO) logistic regression analyses. final constructed validated bootstrap resampling.A total 631 construct...
Plant metabolites represent complex chemical system, which renders it difficult to clarify the composition by conventional liquid chromatography/mass spectrometry (LC/MS) due limited selectivity and peak capacity. The rhizomes of Atractylodes macrocephala have been utilized as a traditional Chinese medicine Atractylodis Macrocephalae Rhizoma (Bai-Zhu), reported containing multiple categories plant metabolites. Targeting multicomponents from A. macrocephala, an integral approach offline...
Purpose Overexpression of breast cancer (BCa) resistance protein (BCRP) is detected in approximately 30% BCa cases. BCRP indicates a poor response to chemotherapy, and it has become classic target overcome drug-resistant tumor cells. In this study, we aimed explore the mechanism overexpression strategy reverse invasive BCa. Methods expression tissues was determined by immunohistochemistry. GSE25066 downloaded from NCBI GEO database. Western blot used determine key molecules vitro . Cell...
Petrological, geochronological, and geochemical analyses of mafic rocks in northern Liaoning were conducted to constrain the formation age Proterozoic strata, further study source characteristics, genesis, tectonic setting. The primarily consist basalt, diabase, gabbro, amphibolite. Results zircon U-Pb chronology reveal four stages magma activities Liaoning: first stage basalt (2209 ± 12 Ma), second diabase (2154 15 third gabbro (2063 7 fourth magmatic protolith amphibolite (2018 13 Ma)....
Angiogenesis is a hallmark of the malignant process in breast cancer which vascular endothelial growth factor A (VEGFA) plays an important role. Trichorhinophalangeal syndrome type 1 (TRPS1) GATA-type transcription and involved trichorhinophalangeal 1. To investigate role TRPS1 angiogenesis, we analyzed expression microvessel density (MVD) marker CD31 by immunohistochemistry 117 paraffin-embedded tissues. was positively correlated with CD31. We further investigated whether TRPS1induces human...
Rebamipide is a routine drug for the treatment of gastritis in clinical setting. Recently, it has been shown to protect against various inflammatory diseases, and provided potential therapy these diseases. However, whether rebamipide role dermatitis remains be elucidated. Here, we found that alleviated reaction induced by tumor necrosis factor-α RAW264.7, stable macrophage cell line. Furthermore, repressed activation nuclear factor-kappaB signaling, well-established signaling pathway....
The role of estrogen receptor β ( ER β) in breast cancer is still under investigation. Various studies have provided evidence that behaves as a tumor suppressor cancer, whereas some α α) negative reported positive correlation between high expression and poor prognostic phenotypes, such induced proliferation, invasion metastasis. In the present immunohistochemistry study 99 α/progesterone PR )‐negative samples, nuclear was positively associated with membranous resistance protein BCRP ), K i67...
Breast cancer resistance protein (BCRP) plays a major role in multidrug (MDR). Sequence analysis reveals there is novel progesterone response element (PRE) the BCRP promoter, suggesting receptor (PR) may have function regulation of expression. We examined expressions BCRP, PR, estrogen α (ERα), androgen (AR) and Her-2 95 breast samples by immunohistochemistry. Then, to identify PR expression, two constructs encoding full length cDNA driven putative PRE promoter or constitutive CMV were...
Multidrug resistance (MDR) is a significant clinical problem in the chemotherapy of osteosarcoma and has been linked to cellular expression several multidrug‐efflux transporters such as MDR1/P‐gp. Our inhibition transcription factor Trps1 led repression MDR1/P‐gp while its overexpression resulted upregulation Flow cytometric analysis suggested increased release anti‐cancer drugs, thus decreasing their accumulation. Immunohistochemical samples indicated that directly correlated with inhibited...
Abstract Background The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity tumor and variable cytologic appearance. Asian experience with diagnosing MTC by fine‐needle aspiration (FNA) was scarcely reported. Methods Cases available FNA slides were enrolled from 13 hospitals representing 8 Asia‐Pacific countries. Clinicopathological information, including sample preparation technique, staining method, original diagnosis review collected....