A5101984643- Molecular Sensors and Ion Detection
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- Nanoparticle-Based Drug Delivery
- Synthesis and biological activity
- Click Chemistry and Applications
- Plant nutrient uptake and metabolism
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Drug Transport and Resistance Mechanisms
- Advanced Chemical Sensor Technologies
- Carbon Nanotubes in Composites
- Photodynamic Therapy Research Studies
- Immune cells in cancer
- Heat shock proteins research
- Microplastics and Plastic Pollution
- ATP Synthase and ATPases Research
- Effects and risks of endocrine disrupting chemicals
- Autophagy in Disease and Therapy
- Nanomaterials for catalytic reactions
- Luminescence and Fluorescent Materials
Tianjin Medical University
2025
Shandong University
2015-2024
University of Massachusetts Amherst
2019-2024
Shanghai Institute of Organic Chemistry
2024
Software (Spain)
2023
Northeast Forestry University
2020
Heilongjiang Academy of Sciences
2020
Wayne State University
2009-2010
The Barbara Ann Karmanos Cancer Institute
2010
St. Jude Children's Research Hospital
2008
Abstract Activating the stimulator of interferon genes (STING) signaling pathway is critical for enhancing antitumor immunity and remodeling immunosuppressive tumor microenvironment (TME). Herein, we report preparation STING‐activating nanoparticles via metal coordination‐driven assembly a synthetic STING agonist (i.e., SR717) chemotherapeutic drug curcumin). After intravenous administration, assembled could efficiently accumulate in tumors to improve bioavailability SR717 trigger potent...
Ten cytoselective compounds have been identified from 372 thiazolidinone analogues by applying iterative library approaches. These selectively killed both non-small cell lung cancer line H460 and its paclitaxel-resistant variant H460taxR at an IC50 between 0.21 2.93 µM while showing much less toxicity to normal human fibroblasts concentrations up 195 µM. Structure–activity relationship studies revealed that (1) the nitrogen atom on 4-thiazolidinone ring (ring B in Figure 1) cannot be...
The induction of autophagy by nanoparticles causes nanotoxicity, but appropriate modulation may have therapeutic potential. Multiwalled carbon nanotubes (MWCNTs) interact with cell membranes and membrane-associated molecules before after internalization. These interactions alter cellular signaling impact major functions such as cycle, apoptosis, autophagy. In this work, we demonstrated that MWCNT-cell can be modulated varying densely distributed surface ligands on MWCNTs. Using a fluorescent...
In this study, the ZmPIS gene with a maize ubiquitin promoter was introduced into (Zea mays L.) inbred line DH4866 by an Agrobacterium‐mediated method to explore function of in response drought stress. The overexpression resulted significantly elevated levels most phospholipids, galactolipids leaves compared those WT and markedly up‐regulated expression some genes involved phospholipids metabolism pathway ABA biosynthesis after Consistent these results, stress tolerance sense transgenic...
We report the one-step assembly of vaccine particles by encapsulating ovalbumin (OVA) and cytosine-phosphate-guanine oligodeoxynucleotides (CpG) into poly(ethylene glycol) (PEG)-mediated zeolitic imidazolate framework-8 nanoparticles (OVA-CpG@ZIF-8 NPs), where PEG improves stability dispersity ZIF-8 NPs protect encapsulated OVA CpG to circumvent cold chain issue. Compared with free OVA-encapsulated (OVA@ZIF-8) NPs, OVA-CpG@ZIF-8 can enhance antigen uptake, cross-presentation, dendritic cell...
This study aims to investigate the potential nanotoxic effects of TiO2 nanoparticles (TNPs) dams and pups during lactation period. are accumulated in mammary glands lactating mice after i.v. administration. accumulation NP likely causes a ROS-induced disruption tight junction blood-milk barrier as indicated by loss proteins shedding alveolar epithelial cells. Compared larger TNPs (50 nm), smaller ones (8 nm) exhibit higher more potent causing perturbations barrier. An alarming finding is...
Water-dispersible Fe(3)O(4) nanoparticles have been prepared by a simple solution method, in which the particle size (3-11 nm) can be tuned simply adjusting reaction temperature and time; formation mechanism of is proposed their low cytotoxicity has also proved.