A5103107869- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Transition Metal Oxide Nanomaterials
- Copper-based nanomaterials and applications
- Luminescence and Fluorescent Materials
- Electronic and Structural Properties of Oxides
- Advanced materials and composites
- Microbial Metabolic Engineering and Bioproduction
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- ZnO doping and properties
- Gas Sensing Nanomaterials and Sensors
- Catalysis and Oxidation Reactions
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Plant biochemistry and biosynthesis
- Ferroptosis and cancer prognosis
- Hydrogels: synthesis, properties, applications
- Intermetallics and Advanced Alloy Properties
- Electrospun Nanofibers in Biomedical Applications
- Cellular Mechanics and Interactions
- Photoacoustic and Ultrasonic Imaging
- nanoparticles nucleation surface interactions
Nanjing Drum Tower Hospital
2025
Nanjing Medical University
2025
Nanjing University of Science and Technology
2025
Shandong First Medical University
2023-2024
Shandong University
2018-2024
Shandong Provincial Hospital
2024
East China University of Technology
2024
Academy of Medical Sciences
2023
Hefei University of Technology
2021-2022
Gannan Normal University
2020-2022
Abstract Subunit vaccines have been investigated in over 1000 clinical trials of cancer immunotherapy, but shown limited efficacy. Nanovaccines may improve efficacy rarely clinically translated. By conjugating molecular with Evans blue (EB) into albumin-binding (AlbiVax), here we develop promising albumin/AlbiVax nanocomplexes that self-assemble vivo from AlbiVax and endogenous albumin for efficient vaccine delivery potent immunotherapy. PET pharmacoimaging, super-resolution microscopies,...
Nanomedicines that co-deliver DNA, RNA, and peptide therapeutics are highly desirable yet remain underdeveloped for cancer theranostics. Herein, we report self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) efficiently delivered synergistic DNA CpG short hairpin RNA (shRNA) adjuvants, as well tumor-specific neoantigens into antigen presenting cells (APCs) in lymph nodes immunotherapy. These nanovaccines were prepared by (1) producing tandem shRNA via concurrent rolling circle...
Integration of magnetic resonance imaging (MRI) and other modalities is promising to furnish complementary information for accurate cancer diagnosis imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity high risk released-Gd-ions-associated toxicity. Herein, a radionuclide-64 Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) developed...
The development of smart theranostic systems with favourable biocompatibility, high loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal diagnostic functionalities is importance for future clinical application. premature burst release poor degradation kinetics indicative polymer-based nanomedicines remain the major obstacles translation. Herein we prepare shell-crosslinked nanoparticles (SCNPs) using a β-cyclodextrin-based polyrotaxane...
On-demand release of carbon monoxide (CO) is realized through a novel near-infrared-responsive nanomedicine in favor the enhancement therapy efficacy and biosafety CO therapy. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher...
We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly transformed into long-circulating nanocomplexes vivo for highly efficient drug delivery effective cancer therapy. Specifically, using redox-responsive disulfide linker, CPT conjugated with an albumin-binding Evans blue (EB) derivative; the resulting amphiphilic CPT-ss-EB self-assembled nanostructures aqueous solution, thus conferring high solubility stability. By binding to endogenous albumin, 80 nm...
A sandwich nanomedicine self-assembled by GO nanosheets and BNN6 exhibits high drug loading capacity NIR responsiveness for NO release.
Glioblastoma (GBM) is the most common and lethal type of malignant brain tumor in adults. Currently, interventions are lacking, median overall survival patients with GBM less than 15 months, postoperative recurrence rate greater 60%. We proposed an innovative local chemotherapy involving construction gene therapy-based iron oxide nanoparticles (IONPs) as a treatment for glioblastoma after surgery that targeted ferroptosis apoptosis to address these problems. The porous structure IONPs...
The clearance of nanoparticles (NPs) by mononuclear phagocyte system (MPS) from blood leads to high liver and spleen uptake negatively impacts their tumor delivery efficiency. Here we systematically evaluated the in vitro vivo nanobio interactions a two-dimensional (2D) model, gold (Au) nanorings, which were compared with Au nanospheres nanoplates similar size. Among different shapes, nanorings achieved lowest MPS highest accumulation. sizes, 50 nm showed In addition, demonstrated potential...
Glioblastoma multiforme (GBM) is a common malignancy of the central nervous system, but conventional treatments yield unsatisfactory results. Although innovative therapeutic approaches have been developed, they prolong survival by only approximately 5 months. The heterogeneity GBM renders growth inhibition with single drug difficult, and exploring combination multiple targets for comprehensive treatment expected to overcome this limitation. In study, we designed biocompatible cRGD/Pt +...
Abstract Precise control of energy migration between sensitizer ions and activator in lanthanide-doped upconversion nanoparticles (UCNPs) nowadays has been extensively investigated to achieve efficient photon upconversion. However, these UCNPs generally emit blue, green or red light only under fixed excitation conditions. In this work, regulation the transition process different levels a single ion obtain tunable fluorescence conditions is achieved by introducing modulator ion. The...
Near-infrared (NIR) light triggered photothermally enhanced cellular internalization strategy shows great potential to improve antitumor effect fight against cancer.In this work, a black phosphorus (BP) nanosheet-based nanomedicine, which is composed of BP nanosheet, human serum albumin (HSA) and paclitaxel (PTX), was developed for mild hyperthermia-enhanced intracellular drug delivery chemo-photothermal combination therapy.BP nanosheet successfully synthesized by one-pot biomimetic...
Abstract Mutations in genes encoding isocitrate dehydrogenases (IDH) 1 and 2 are common cancer-related genetic abnormalities. Malignancies with mutated IDHs exhibit similar pathogenesis, metabolic pattern, resistance signature. However, an effective therapy against IDH1-mutated solid tumor remains unavailable. In this study, we showed that acquisition of IDH1 mutation results the disruption NADP+/NADPH balance increased demand for glutathione (GSH) metabolism. Moreover, nuclear factor...
We report the one-step assembly of vaccine particles by encapsulating ovalbumin (OVA) and cytosine-phosphate-guanine oligodeoxynucleotides (CpG) into poly(ethylene glycol) (PEG)-mediated zeolitic imidazolate framework-8 nanoparticles (OVA-CpG@ZIF-8 NPs), where PEG improves stability dispersity ZIF-8 NPs protect encapsulated OVA CpG to circumvent cold chain issue. Compared with free OVA-encapsulated (OVA@ZIF-8) NPs, OVA-CpG@ZIF-8 can enhance antigen uptake, cross-presentation, dendritic cell...
A supramolecular hybrid material is developed as ultrasound and photoacoustic signals nanoamplifier.
Abstract Activatable imaging probes are promising to achieve increased signal‐to‐noise ratio for accurate tumor diagnosis and treatment monitoring. Magnetic resonance (MRI) is a noninvasive technique with excellent anatomic spatial resolution unlimited tissue penetration depth. However, most of the activatable MRI contrast agents suffer from metal ion‐associated potential long‐term toxicity, which may limit their bioapplications clinical translation. Herein, an agent efficient performance...
Accurate diagnosis of tumor is promising to guide photothermal therapy (PTT) for efficacious ablation with minimal damage healthy tissues. Here, we report an activatable dual-modal imaging agent, which based on PEGylated-gadolinium metallofullerene-polypyrrole nanoparticle (PEG-GMF-PPy NP) imaging-guided PTT. A contrast agent (gadolinium metallofullerene, GMF) excellent magnetic resonance (MRI) performance and ultra-pH-responsive polymer (PEG-PC7A) are successively modified the surface (PPy...
Molecular design of biomaterials with unique features recapitulating nature's niche to influence biological activities has been a prolific area investigation in chemistry and material science. The extracellular matrix (ECM) provides wealth bioactive molecules supporting cell proliferation, migration, differentiation. well-patterned fibril intertwining architecture the ECM profoundly influences behavior development. Inspired by those from ECM, we attempted integrate essential factors...
Recent advances in neural stem cell (NSC) transplantation have led to an inspiring progress alleviating central nervous system (CNS) damages and restoring brain functions from diseases or injuries. One challenge of NSC is directed differentiation transplanted NSCs into desired neuronal subtypes, such as neurons, compensate the adverse impact injury; another lies lack tools noninvasively monitor dynamics after vivo. In this study, we developed a polymer nanovehicle for morphogen sustained...
Gold nanoparticles (AuNPs) have been increasingly integrated in biological systems, making it imperative to understand their interactions with cell membranes, the first barriers be crossed enter cells. Herein, liposomes composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) as a model membrane system were treated citrate stabilized AuNPs from 5 30 nm at various concentrations. The fluorescence shifts Laurdan probes reveal that general made more fluidic. increased fluidity is expected...