A5053551404- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Antimicrobial agents and applications
- Bone Tissue Engineering Materials
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Surface Modification and Superhydrophobicity
- Electrospun Nanofibers in Biomedical Applications
- Bacterial biofilms and quorum sensing
- Catalytic Processes in Materials Science
- Antimicrobial Peptides and Activities
- Nanoparticle-Based Drug Delivery
- Catalysts for Methane Reforming
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Drug Delivery Systems
- Wound Healing and Treatments
- Advanced Nanomaterials in Catalysis
- Cellular Mechanics and Interactions
- Metal and Thin Film Mechanics
- Fermentation and Sensory Analysis
- Orthopedic Infections and Treatments
- Catalysis and Oxidation Reactions
- Molecular Junctions and Nanostructures
- Dental materials and restorations
Flinders University
2020-2025
University of South Australia
2015-2024
VDE Prüf- und Zertifizierungsinstitut (Germany)
2022
John Wiley & Sons (Germany)
2019-2022
Fraunhofer Institute for Interfacial Engineering and Biotechnology
2019-2022
Ruhr University Bochum
2022
Polytechnique Montréal
2019-2022
University of Bari Aldo Moro
2019-2022
Australian Wine Research Institute
2022
Great Lakes Institute of Management
2015-2020
Osteoimmunomodulation has informed the importance of modulating a favorable osteoimmune environment for successful materials-mediated bone regeneration. Nanotopography is regarded as valuable strategy developing advanced materials, due to its positive effects on enhancing osteogenic differentiation. In addition this direct effect osteoblastic lineage cells, nanotopography also plays vital role in regulating immune responses, which makes it possible utilize immunomodulatory properties create...
To ensure the availability of clean water for humans into future, efficient and cost-effective purification technology will be required. The rapidly decreasing quality growing global demand this scarce resource has driven pursuit high-performance materials, particularly application as point-of-use devices. This review introduce main types natural artificial contaminants that are present in challenges associated with their effective removal. efficiency performance recently developed materials...
Abstract Nanoparticles have become an important utility in many areas of medical treatment such as targeted drug and delivery well imaging diagnostics. These advances require a complete understanding nanoparticles' fate once placed the body. Upon exposure to blood, proteins adsorb onto nanoparticles surface form protein corona, which determines particles' biological fate. This study reports on corona formation from blood serum plasma spherical rod‐shaped nanoparticles. two types mesoporous...
The nature of the protein corona forming on biomaterial surfaces can affect performance implanted devices. This study investigated role surface chemistry and wettability human serum-derived formation subsequent effects cellular innate immune response. Plasma polymerization, a substrate-independent technique, was employed to create nanothin coatings with four specific chemical functionalities spectrum charges wettability. amount type adsorbed strongly influenced by but did not show any...
Excessive mechanical stress is closely associated with cell death in various conditions. Exposure of chondrocytes to excessive loading leads a catabolic response as well exaggerated death. Ferroptosis recently identified form during aging and degeneration. However, it's potential association remains be illustrated.To identify whether can cause ferroptosis. To explore the role overloading chondrocyte ferroptosis.Chondrocytes were collected from unloading zones cartilage patients...
Abstract Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative disorders and imposes places heavy medical economic burdens on individuals society. Mechanical overloading applied to intervertebral (IVD) has been widely recognized as an important cause IVDD. overloading-induced chondrocyte ferroptosis was reported, but potential association between mechanical remains be illustrated in nucleus pulposus (NP) cells. In this study, we discovered that excessive...
Tethered lipid bilayers (tBLMs) were obtained by the fusion of liposomes from diphytanoylphosphatidylcholine (DPhyPC) with self-assembled monolayers (SAMs) a newly designed archaea analogue thiolipid, 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-d,l-α-lipoic acid ester (DPTL) on template stripped gold (TSG) films silicon wafer as template. SAMs, characterized reflection absorption infrared spectroscopy (RAIRS), show mixture different conformations tetraethylene segment in air, which...
We have synthesized a series of copolymers containing both positively charged (amine, guanidine) and hydrophobic side chains (amphiphilic antimicrobial peptide mimics). To investigate the structure–activity relationships these polymers, low polydispersity polymethacrylates varying but uniform molecular weight composition were synthesized, using reversible addition–fragmentation chain transfer (RAFT) approach. In facile second reaction, pendant amine groups converted to guanidines, allowing...
Reduced graphene oxide (rGO) is a promising antibacterial material, the efficacy of which can be further enhanced by addition silver nanoparticles (nAg). In this study, mechanisms activity rGO-nAg nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely Gram-positive coccal Staphylococcus aureus and Gram-negative rod-shaped Escherichia coli Proteus mirabilis are investigated. At same concentration (100 µg/ml), was significantly more effective all three...
Abstract Bacterial colonisation of synthetic materials surfaces is an important problem in many fields and consequently there have been considerable efforts over decades to find solutions. This review discusses plasma‐based strategies for combating infections at biomedical implants devices, caused by the attachment bacteria their subsequent biofilm formation on device surfaces. Plasma polymerisation plasma treatment become attractive modalities developing antibacterial coatings various...
Bacterial infections present an enormous problem causing human suffering and cost burdens to healthcare systems worldwide. Here we novel tunable antibacterial coatings which completely inhibit bacterial colonization by Staphylococcus epidermidis but allow normal adhesion spreading of osteoblastic cells. The are based on amine plasma polymer films loaded with silver nanoparticles. method preparation allows flexible control over the amount nanoparticles rate release ions.
In this communication, we present a novel approach for control of drug release from porous materials. The method is based on deposition plasma polymer layer with controlled thickness which reduces pore diameter and, hence, defines the rate release.
Antibacterial nanodevices could bring coatings of plastic materials and wound dressings a big step forward if the release antibacterial agents be triggered by presence bacteria themselves. Here, we show that novel hyaluronic acid (HA)-based nanocapsules containing antimicrobial agent polyhexanide are specifically cleaved in hyaluronidase, factor pathogenicity invasion for like Staphylococcus aureus Escherichia coli. This resulted an efficient killing pathogenic agent. The formation different...
Poor aqueous solubility of some drug molecules is a major problem in formulation. Drug nanosuspensions emerged as one solution to delivering such hydrophobic drugs. Scaling down nanoparticles enhances and bioavailability by increasing surface area that comes into contact with biological media. Nanosuspensions have attracted particular attention are those sterically stabilised steric polymers polyethylene glycol (PEG) typical size range 10–100 nm. These capable accumulating targeted areas...
Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy patients. Methods: NP tissue cells were isolated from patients mice, expression profile cortistatin (CST) was analysed. In addition, ageing compared between 6-month-old WT CST-knockout (CST-/-) mice. Furthermore, tissues cultured validate role CST TNF-α-induced IVD degeneration. Moreover, vitro vivo experiments...
Ultrasmall silver nanoparticles (AgNPs; size < 3 nm) have attracted a great deal of interest as an alternative to commercially available antibiotics due their ability eliminate wide range microbial pathogens. However, most these ultrasmall AgNPs are highly reactive and unstable, well susceptible fast oxidation. Therefore, both the stability toxicity remain major shortcomings for clinical application uptake. To circumvent problems, we present novel strategy impregnate into biocompatible...