A5103843670- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Protein Interaction Studies and Fluorescence Analysis
- Liver Disease Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cholesterol and Lipid Metabolism
- Cutaneous Melanoma Detection and Management
- DNA and Nucleic Acid Chemistry
- Cancer survivorship and care
- Peroxisome Proliferator-Activated Receptors
- Molecular Sensors and Ion Detection
- Lipoproteins and Cardiovascular Health
- Cancer therapeutics and mechanisms
- Patient-Provider Communication in Healthcare
- Trace Elements in Health
- Ferroptosis and cancer prognosis
- Non-Invasive Vital Sign Monitoring
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cardiovascular Health and Disease Prevention
- Bone Metabolism and Diseases
- Machine Learning in Healthcare
- Protein Structure and Dynamics
Zhengzhou People's Hospital
2024
Dalian Medical University
2019-2023
Dalian University
2023
Guangxi University
2022
Guangdong Pharmaceutical University
2022
Qilu Hospital of Shandong University
2021
Shandong University
2021
National Clinical Research Center for Digestive Diseases
2020
Capital Medical University
2020
Beijing Friendship Hospital
2020
Cross-drug resistance in multidrug-resistant (MDR) cells, which overexpress P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major impediment to successful chemotherapy for colorectal cancer. In present study, drug-sensitive HCT8 and (vincristine, VCR) HCT8/V cancer cell lines were used examine role of c-Jun NH2-Terminal Kinase- (JNK) signaling pathway P-gp-mediated MDR associated with Cyclo-oxygenase-2 (COX-2). The results showed that SP600125, JNK inhibitor, NS-398, COX-2 significantly...
Purpose Overexpression of breast cancer (BCa) resistance protein (BCRP) is detected in approximately 30% BCa cases. BCRP indicates a poor response to chemotherapy, and it has become classic target overcome drug-resistant tumor cells. In this study, we aimed explore the mechanism overexpression strategy reverse invasive BCa. Methods expression tissues was determined by immunohistochemistry. GSE25066 downloaded from NCBI GEO database. Western blot used determine key molecules vitro . Cell...
Abstract Activation of the MDR 1 ( ABCB 1) gene is a common event conferring multidrug resistance (MDR) in human cancers. We investigated activation variants sarcoma line, some which express mutant 1, facilitated study allelic expression. Structural alterations copy numbers, and expression were analyzed by cytogenetic karyotyping, oligonucleotide hybridization, Southern blotting, polymerase chain reaction, DNA heteroduplex assays. Both chromosome 7 several changes involving 7q21 locus are...
Human P-glycoprotein (P-gp), a kind of ATP-Binding Cassette transporter, can export diverse variety anti-cancer drugs out the tumor cell. Its overexpression is one main reasons for multidrug resistance (MDR) cells. It has been confirmed that during substrate transport process, P-gp experiences large-scale structural rearrangement from inward- to outward-facing states. However, mechanism how nucleotide-binding domains (NBDs) control transmembrane (TMDs) open towards periplasm in state not yet...
Patients who effectively manage their symptoms often demonstrate higher levels of engagement in conversations and interventions with healthcare practitioners. This is multifaceted, encompassing cognitive social dimensions. Consequently, it crucial for AI systems to understand the natural between patients practitioners better contribute toward patient care. In this paper, we present a novel dataset (MedNgage), which consists patient-nurse about cancer symptom management. We manually annotate...
Background and objectivesAlbumin is a major prognostic factor for patients with advanced liver disease, dependent on its concentration biological activity. This study aimed to improve the method of active albumin detection elucidate predictive validity activity across hepatic disease progression etiology.
It is unknown whether acral melanomas (AMs) associated with pre-existing nevi have similar risk to other AMs. To compare of recurrence and death between AMs de novo We conducted a multicenter retrospective cohort study involving patients diagnosed February 2011 November 2022. About 164 (34.0%) had nevus-associated melanoma (NAAM). NAAM has lower (hazard ratio: 0.69; 95% CI: 0.52-0.91; P = .008) mortality 0.53; 0.37-0.76; < .001) than (DNAM). The 5-year recurrence-free survival (RFS) was...
The aim of this study was to find a non-invasive pulse wave waveform index that highly correlated with cardiovascular disease and establish an effective model for health assessment in middle-aged men provide early warning possible cerebrovascular diseases. Considering the characteristics easy detect rich physiological information, paper collected waves healthy males at six age groups, 50 samples per group. parameters each sample were extracted, including inflow time, outflow total beat fast...
Cancer Drug Resistance is an open access journal, focusing on pharmacological aspects of drug resistance and its reversal, molecular mechanisms classes, etc. Both clinical experimental in cancer are included.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, yet treatment options are limited. Clozapine (CLZ), an antipsychotic used for schizophrenia, has potential as a PD treatment. CLZ and its metabolite, Clozapine-N-Oxide (CNO), show neuroprotective effects on dopaminergic neurons, with mechanisms needing further investigation. This study aimed to confirm of CNO in rotenone-induced mouse model explore underlying CNO-afforded protection. Gait pattern rotarod activity...
Background: ABCB1, EPHX1 and SCN1A gene polymorphisms have been reported play important roles in individual variability carbamazepine (CBZ) metabolism resistance, but the result of that association still remains controversial. Objective: To clarify associations among CBZ resistance. Methods: The PubMed, EMBASE, Cochrane library, Chinese National Knowledge Infrastructure, Science Technique Journals Database, China Biology medicine disc Wan Fang Database were searched for appropriate studies...
Currently, atherosclerosis control is important to prevent future heart attacks or strokes. Protein-enriched extract (PE) from housefly maggots (Musca domestica) can inhibit the development of partially through its antioxidant effects. Whether PE exerts other anti-atherosclerosis functions remains unclear. Here, was found simultaneously promote cholesterol metabolism effects in apolipoprotein E knockout (ApoE-/- ) mice. Bile acid synthesis plays a key role regulating homeostasis...