A5101973377- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Cardiovascular Syncope and Autonomic Disorders
- Biomarkers in Disease Mechanisms
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Nitric Oxide and Endothelin Effects
- Cardiac Arrhythmias and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Fibrosis and Remodeling
- Pain Management and Treatment
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Axon Guidance and Neuronal Signaling
- Lipoproteins and Cardiovascular Health
- Heart rate and cardiovascular health
- Cardiomyopathy and Myosin Studies
- Cardiac Health and Mental Health
- Helicobacter pylori-related gastroenterology studies
- Protein Interaction Studies and Fluorescence Analysis
Wuhan Puai Hospital
2011-2025
Huazhong University of Science and Technology
2008-2020
Ningbo University
2017
Jianghan University
2016
<title>Abstract</title> Previous preclinical studies suggested that Shexiang Tongxin Dropping Pill (STDP) would be effective for coronary slow flow phenomenon (CSFP), but its clinical efficacy and safety remain uncertain. A multicenter, randomized, controlled phase IV trial was implemented to enroll 200 participants diagnosed with angina CSFP between July 2016 August 2020 examine the drug’s effectiveness safety. The analysis revealed corrected TIMI frame count (CTFC) values in left anterior...
Objective Autonomic dysfunction is recognized in patients with coronary artery disease (CAD) and related to worse cardiovascular outcome. This study aimed evaluate cardiac autonomic nervous function by heart rate recovery (HRR) variability (HRV), demonstrate their relationship the severity of lesions stable CAD (SCAD). Methods Consecutive without (controls, n = 65) those SCAD (n 63) were included this study. Patients further divided into single- or two-/three-vessel disease, as well <70%...
Objective The aim of this study is to observe the chronic effects diltiazem release capsules on patients with coronary slow flow (CSF) phenomenon. Methods From 2004 2009, 80 consecutive chest pain and normal arteries evidenced by angiography CSF were included in randomized, double-blind, placebo-controlled trial. patterns evaluated corrected TIMI frame count. Patients randomly assigned at 1∶1 ratio sustained-release treatment group (Dil, 90 mg twice daily) or placebo control group. Holter,...
Adenosine diphosphate P2Y12 receptor antagonist clopidogrel is not sufficiently safe for the gastric mucosa in patients with high risk of peptic ulcer, since it may impair healing erosions. However, safety novel ticagrelor has been elucidated to date. The present study aimed examine whether delays ulcer and elucidate involved mechanisms. Gastric kissing ulcers were produced rats by luminal application acetic acid solution, was administered at dose 10 or 20 mg/kg/day orally 7 days. On day 8...
Abstract Reducing sympathetic neurohormone expression is a key therapeutic option in attenuating cardiac remodelling. Present study tested the feasibility of remodelling through reducing level by partial denervation rat model chronic volume overload. Male Sprague‐Dawley rats were randomized into sham group (S, n = 7), aortocaval fistula ( AV , and with bilateral stellate ganglionectomy AD 8). After 12 weeks, myocardial protein neurohormones, including tyrosine hydroxylase, neuropeptide Y,...
We previously reported significantly enhanced cardiac remodeling post aortocaval fistula (AV) in unilateral nephrectomized (UNX) rats. However, the relationship between size of AV and cardiorenal effects UNX rats remains unknown. In present study, was induced by 20, 18 16 gauge needles to see if larger shunt would definitely induce heavier renal damage Our results demonstrated that bigger is linked with proportional more significant dysfunction Expression inflammatory biomarkers including...
The aim of this study was to assess the feasibility evaluating therapeutic effects intravenous diltiazem in a newly established rat model coronary thrombotic micro-embolism (CME). CME induced by injecting 0.199 ml saline containing 5 mg automicrothrombotic particulates (∼10 μm) into aorta Sprague Dawley rats. injection carried out over 10 sec using tuberculin syringe with 28-gauge needle. rats were randomly divided untreated (CME, n=38) and diltiazem-treated (CME+DIL, groups. Diltiazem (1...
Objective . Pathomechanism of coronary slow flow phenomenon remains largely unclear now. Present study observed the pathological and angiographic evolution in a pig model flow. Methods Coronary was induced by repeat injection small doses 40 µ m microspheres 18 male domestic pigs changes were determined at 3 hours, 7 days, 28 days after injection. Results Compared to control group treated with saline injection<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background We previously reported that bilateral sympathetic stellate ganglionectomy attenuated cardiac remodeling and fibrosis in rats with chronic volume overload. Transforming growth factor beta 1 (TGF-β1) is a polypeptide member of the transforming superfamily cytokines actively involved many pathological processes cardiovascular diseases. Present study explored impact on TGF-β1 pathway this model. Methods Results Male Sprague-Dawley were randomly divided into sham (S) group, abdominal...
Background and objectivesAlbumin is a major prognostic factor for patients with advanced liver disease, dependent on its concentration biological activity. This study aimed to improve the method of active albumin detection elucidate predictive validity activity across hepatic disease progression etiology.
Non-pharmacological therapies, especially the physical maneuvers, are viewed as important and promising strategies for reducing syncope recurrences in vasovagal (VVS) patients. We observed efficacy of a modified Valsalva maneuver (MVM) VVS 72 patients with history positive head-up tilt table testing (HUTT) results were randomly divided into conventional treatment group (NVM group, n = 36) plus standard MVM 30 days (MVM 36). Incidence recurrent after 12 months (6.5% vs. 41.2%, P<0.01) rate...
Objectives: In arterial hypertension, aminoterminal propeptide of type III procollagen (PIIINP) is elevated in aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI).Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP.This study was conducted to establish if short-term rhGH affects PIIINP, function selected cardiovascular disease (CVD) risk factors, healthy males.Design: Method: Male subjects...