A5101983586- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Urological Disorders and Treatments
- Gastrointestinal disorders and treatments
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Renal and related cancers
- Toxin Mechanisms and Immunotoxins
- MRI in cancer diagnosis
- Cancer-related Molecular Pathways
- Natural Fiber Reinforced Composites
- Chemokine receptors and signaling
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bamboo properties and applications
- Ubiquitin and proteasome pathways
- Parvovirus B19 Infection Studies
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
Dalian Medical University
2023
Second Affiliated Hospital of Dalian Medical University
2023
Shanghai Institutes for Biological Sciences
2016-2018
Institut Pasteur of Shanghai
2016-2018
Henan Agricultural University
2016
Providence College
2015
Boston University
2015
University of Michigan
2013-2015
We previously reported the discovery of a class spirooxindoles as potent and selective small-molecule inhibitors MDM2–p53 interaction (MDM2 inhibitors). report herein our efforts to improve their pharmacokinetic properties in vivo antitumor activity. Our led identification 9 (MI-888) MDM2 inhibitor (Ki = 0.44 nM) with superior profile enhanced efficacy. Compound is capable achieving rapid, complete, durable tumor regression two types xenograft models human cancer oral administration...
Hepatitis C virus (HCV) entry is a multiple-step process involving number of host factors and hence represents promising target for new antiviral drug development. In search novel inhibitors HCV infection, we found that human apolipoprotein E (apoE) peptide, hEP, containing both receptor binding fragment lipid apoE specifically blocked the cell culture grown (HCVcc) at submicromolar concentrations. hEP caused little cytotoxicity in vitro remained active even if left 24 hours culture....
Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that cellular proteins prohibitin 1 (PHB1) 2 (PHB2) are pan-genotypic HCV entry factors functioning at post-binding step. While predominantly found mitochondria, PHBs localize to plasma membrane hepatocytes through their transmembrane domains interact with both EGFR CRaf. Targeting PHB by rocaglamide (Roc-A), natural...
Hepatitis C virus (HCV) infects 2 to 3% of the world population and is a leading cause liver diseases such as fibrosis, cirrhosis, hepatocellular carcinoma. Many aspects HCV study, ranging from molecular virology antiviral drug development resistance profiling, were supported by straightforward assays replication infection. Among these assays, HCV-dependent fluorescence relocalization (HDFR) system allowed live-cell visualization infection without modifying viral genome, but this strategy...
The classical lytic infection theory along with large T antigen-mediated oncogenesis cannot explain the BK polyomavirus (BKPyV)-associated tumor secondary to BKPyV-associated nephropathy (BKVAN), viremia/DNAemia, and viruria after renal transplantation. This study performed virome capture sequencing pathological examination on regularly collected urine sediment peripheral blood samples, BKVAN biopsy tissues of 20 patients diseases different stages. In early noncancerous stages,...
Liposarcomas involving the kidney are rare, with most appearing as secondary involvement from large pararenal liposarcomas. A 77-year-old male patient presented acute flank pain. CT scans demonstrated a large, thick-walled cystic lesion rim calcifications "arising right inferior kidney." MRI revealed 16.3 cm complex mass pushing border against uninvolved lower renal pole. primary cell neoplasm was favored based on radiological findings. The underwent radical nephrectomy and adrenalectomy....
Upper female genital tract vascular proliferations are rare and generally not well characterized. We evaluated types, differences in distribution, associations of such lesions. Fifty-five lesions were identified: 42 benign (ovary 24; uterine corpus 11; para-adnexal 4; fallopian tube 1; ovaries, tubes, ovary 1) 13 angiosarcomas. Patients with had a mean age 55 (range: 13–82) yr. Twenty-six incidental findings, 11 associated clinical manifestations. They size 2.0 <1–13) cm, often grossly...
Foregut duplication cyst is most commonly seen in the posterior mediastinum without communication with adjacent organs or presence of other malformations and typically shows ectopic gastric respiratory epithelium. The finding pancreatic tissue extremely rare. A 15-year-old female patient presented elevated blood pressure, intermittent right flank pain for 18 months. An abdominal MRI revealed a 4 cm cystic retroperitoneal mass, initially thought to arise from adrenal gland. Intraoperatively,...
Hepatitis C virus (HCV) spread involves two distinct entry pathways: cell-free transmission and cell-to-cell transmission. Cell-to-cell is not only an efficient way for viruses to but also effective method escaping neutralizing antibodies. We adapted the viral infection-activated split-intein-mediated reporter system (VISI) developed a straightforward model Live-cell monitoring of HCV ex-vivo: co-culture infected donor cells (red signal) with uninfected recipient (green elimination by adding...
<p>Validation of various acetyl-Src antibodies</p>
<p>Expression of acetyl-Src and phospho-Stat3 in cancer tissues</p>
<p>Src global post-translational modifications are triggered by CBP</p>
<p>Src plasma membrane association and dissociation under different conditions</p>
<p>Src global post-translational modifications are triggered by CBP</p>
<p>Interaction between Src and CBP</p>
<p>Src plasma membrane association and dissociation under different conditions</p>
<p>Expression of acetyl-Src and phospho-Stat3 in cancer tissues</p>