A5101964970- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Circular RNAs in diseases
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Pediatric health and respiratory diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hedgehog Signaling Pathway Studies
- Diabetes Treatment and Management
- Syphilis Diagnosis and Treatment
- RNA Research and Splicing
- Extraction and Separation Processes
- Cardiovascular Health and Risk Factors
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Congenital gastrointestinal and neural anomalies
- Neuroscience and Neural Engineering
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autophagy in Disease and Therapy
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
Chengdu University of Traditional Chinese Medicine
2023-2025
Tianjin Medical University
2025
China Mobile (China)
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Honghe University
2024
Sun Yat-sen University
2024
Shanghai Electric (China)
2024
Aim Glycyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In present study, protective effects GL I/R injury, as well related molecular mechanisms, were investigated in rat brains. Methods Focal cerebral was induced intraluminal filamentous occlusion middle artery (MCA) Male Sprague-Dawley rats. alone or rHMGB1 administered intravenously at time reperfusion. Serum levels...
Suboptimal health status (SHS) is the intermediate state between and disease, refers to medically undiagnosed or functional somatic syndromes, has been a major global public challenge. However, both etiology mechanisms associated with SHS are still unclear. Breakfast eating behavior dietary pattern marker previous studies have presented evidence of associations failure consume breakfast increased diseases. Accordingly, in view significance behaviors respect status, habits healthy lifestyle,...
Although glioblastoma multiforme (GBM) is the most malignant primary human brain cancer with surprisingly high incidence rate in adult men than women, exact mechanism underlying this pronounced epidemiology unclear. Here, we showed significant upregulated androgen receptor (AR) expression GBM tissue compared to periphery normal patients. An of AR was further detected all eight examined cell lines. To figure out whether signaling may play a role GBM, used AR-expressing U87-MG line for study....
Long noncoding RNAs (lncRNA) have essential roles in diverse cellular processes, both normal and diseased cell types, thus emerged as potential therapeutic targets. A specific member of this family, the SWI/SNF complex antagonist associated with prostate cancer 1 (SChLAP1), has been shown to promote aggressive growth by antagonizing therefore serves a biomarker for poor prognosis. Here, we investigated whether SChLAP1 plays role development human glioblastoma (GBM).RNA-ISH IHC were performed...
Honokiol is a low-molecular-weight natural product and has been reported to exhibit anti-inflammatory activity.Our study aimed investigate the influence of honokiol on sepsis-induced acute kidney injury (AKI) in mouse model.A cecal ligation puncture (CLP) surgical operation was performed establish model mice. Renal histomorphological analysis with periodic acid-Schiff (PAS) staining. The levels inflammatory markers serum were measured by ELISA assay. mRNA protein assayed RT-qPCR western...
Rationale: It has been emergingly recognized that apoptosis generates plenty of heterogeneous apoptotic vesicles (apoVs), which play a pivotal role in the maintenance organ and tissue homeostasis.However, it is unknown whether apoVs influence postnatal ovarian folliculogenesis.Methods: Apoptotic pathway deficient mice including Fas mutant (Fas mut ) ligand (FasL were used with apoV replenishment to evaluate biological function during folliculogenesis.Ovarian was characterized by...
Increasing evidence suggests that features of the gut microbiota correlate with ischemic stroke. However, specific characteristics in patients suffering different types stroke, or recovering from such strokes, have rarely been studied, and potential microbiotic predictors stroke seldom analyzed. We subjected fecal specimens lacunar non-lacunar acute infarctions, those to bacterial 16S rRNA sequencing compared results healthy volunteers. identified microbial markers verified these were...
Ischemic stroke (IS) is a serious central nervous system disease. Post-IS complications, such as post-stroke cognitive impairment (PSCI), depression (PSD), hemorrhagic transformation (HT), gastrointestinal dysfunction, cardiovascular events, and infection (PSI), result in neurological deficits. The microbiota-gut-brain axis (MGBA) facilitates bidirectional signal transduction communication between the intestines brain. Recent studies have reported alterations gut microbiota diversity...
Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely unknown. Here, we investigated the of PIK3R1 HCC and examined underlying molecular mechanisms. The expression was evaluated by immunohistochemistry qRT-PCR a series tissues. mRNA protein used western blot assays human lines, then choose MHCC97H HCCLM3 cells as model to investigate effect on...
Suboptimal health status (SHS)—an intermediate state between and illness—refers to functional somatic symptoms that are medically undiagnosed. Although SHS has become a great challenge for global public health, very little about its etiology mechanisms known. Work-recreation balance is part of work−life balance, related stress which greatly influences status. We therefore carried out cross-sectional investigation 2012 2013 within clustered sample 24,475 individuals aged 15−60 years from...
Chaperone-mediated autophagy (CMA) serves as a critical upstream regulator of lipophagy and lipid metabolism in hepatocyte. However, the role CMA macrophage, typical component atherosclerotic plaque, remains unclear. In our study, LAMP-2A (L2A, marker) was reduced macrophages exposed to high dose oleate, impaired advanced atherosclerosis ApoE (-/-) mice. Primary peritoneal isolated from macrophage-specific L2A-deficient mice exhibited pronounced intracellular accumulation. Lipid regulatory...
Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. However, its exact mechanism of action (MOA) remains unclear. This study aimed to investigate the pharmacological activity and underlying MOA. The inhibitory effect ORes on cancer cell growth was confirmed, effective concentrations were determined for further experiments. Gene expression profiles (GEPs) collected from MDA-MB-231 cells treated with at varying using HTS2. Bioinformatics tools...
Objective: In-stent neoatherosclerosis is a phenomenon of percutaneous coronary intervention with stenting. Whilst similar to de novo atherosclerosis, it develops rapidly over 1-5 years rather than lifetime. No preclinical small animal models exist that allow full elucidation biology and future treatments. The aim this study was establish validate novel murine model in-stent neoatherosclerosis. Approach Results: Murine stainless-steel stents (2.5 x 0.7 mm) were deployed into donor descending...
This study focused on the special clinical context of pregnancy with cervical cancer to comprehensively evaluate efficacy and safety neoadjuvant chemotherapy. Through analysis relevant cases comprehensive studies, role chemotherapy in controlling tumor progression improving survival rate patients during was discussed, adverse effects mothers infants were closely paid attention to, including potential risks fetal development, physical conditions pregnant women outcomes. Comprehensive...