A5018114296- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Cardiovascular Health and Risk Factors
- Pharmacological Effects of Natural Compounds
- Dermatology and Skin Diseases
- Medical and Biological Ozone Research
- Diverticular Disease and Complications
- Signaling Pathways in Disease
- Ion Channels and Receptors
- Urticaria and Related Conditions
- Nutritional Studies and Diet
- Inflammatory Bowel Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Gastrointestinal disorders and treatments
- Estrogen and related hormone effects
- Obesity, Physical Activity, Diet
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- High Altitude and Hypoxia
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
Second Affiliated Hospital of Guangzhou Medical University
2020-2025
Guangzhou Medical University
2020-2025
Zhejiang University
2025
Zhejiang Cancer Hospital
2025
Lilly (China)
2018
Southern Medical University
2014
Nanfang Hospital
2014
Suboptimal health status (SHS) is the intermediate state between and disease, refers to medically undiagnosed or functional somatic syndromes, has been a major global public challenge. However, both etiology mechanisms associated with SHS are still unclear. Breakfast eating behavior dietary pattern marker previous studies have presented evidence of associations failure consume breakfast increased diseases. Accordingly, in view significance behaviors respect status, habits healthy lifestyle,...
The nod-like receptor family pyrin domain-containing 3 (NLRP3) has been implicated in various skin diseases. However, its role mediating 2, 4-dinitrofluorobenzene (DNFB)-induced chronic itch remains unclear. Widetype (WT) and Nlrp3 deletion (Nlrp3-/- )mice, the expression of transient potential (TRP) ankyrin 1 (TRPA1) inhibitor or recombinant mice interleukin-18 (IL-18) were used to establish evaluate severity DNFB-mediated itch. Quantitative real-time PCR, western blotting,...
Neuropathic pain is a distressing medical condition with few effective treatments. The role of Vascular endothelial growth factor A (VEGFA) in inflammation has been confirmed many researches. However, the mechanism VEGFA affects neuropathic remains unclear. In this study, we demonstrated that plays an important spare nerve injury (SNI)-induced pain, which mediated by enhanced expression and colocalized VEGFA, p-AKT TRPV1 SNI-induced model. Soluble VEGFR1 (sFlt1) not only relieved mechanical...
Morphine-induced scratching (MIS) is a common adverse effect associated with the use of morphine as analgesia after surgery. However, treatment MIS less than satisfactory due to its unclear mechanism, which needs be enunciated. We found that intrathecal (i.t.) injections significantly enhanced behavior in C57BL/6J male mice well increased expressions protein kinase C β (PKCβ), phosphorylated p38 mitogen-activated kinases (MAPK), and ionized calcium-binding adapter molecule 1 (Iba1) within...
Methionine aminopeptidase 2 (MetAP2) cleaves the initiator methionine from nascent peptides during translation. In both preclinical and clinical studies, pharmacological inhibition of MetAP2 in obese subjects results suppression food intake body weight loss. However, mechanism action loss caused by remains to be elucidated, sites remain unknown.In present study, a comprehensive analysis expression pattern mice was performed.Except for relatively low adipose tissues, protein well-expressed...
Abstract Morphine-induced scratching (MIS) is a common issue in patients receiving clinical postoperative morphine intrathecal injections. The kappa opioid receptor (KOR) agonist nalbuphine known to prevent and reduce MIS, but the underlying mechanism has remained unclear. Here, we found that protein kinase C (PKCβ) spinal cord dorsal horn was co-expressed with ionized calcium binding adapter molecule 1 (Iba1) increased after (i.t.) injections mice. Although knockdown PKCβ inhibited...