A5102806983- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Hemostasis and retained surgical items
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Fungal Biology and Applications
Affiliated Hospital of Guizhou Medical University
2016-2025
Guiyang Medical University
2016-2025
Second People’s Hospital of Huai’an
2022
Huaian First People’s Hospital
2022
Nanjing Medical University
2022
Xuzhou Medical College
2022
Zhongda Hospital Southeast University
2020
Shanghai Tenth People's Hospital
2020
Tongji University
2020
Anhui Medical University
2020
To evaluate the clinical and computed tomographic (CT) features in patients with COVID-19 pneumonia confirmed by real-time reverse transcriptase polymerase chain reaction (rRT-PCR) amplification of viral DNA from a sputum sample.
Background Multiparametric magnetic resonance imaging (MRI) is widely used in breast cancer screening. Accurate prediction of the axillary lymph nodes metastasis (ALNM) essential for surgery and treatment. However, there no mature effective discerning method ALNM based on multiparametric MRI. Purpose To evaluate using T1‐weighted (T1WI), T2‐weighted (T2WI), diffusion‐weighted (DWI) sequences, respectively, construct a quantitative model integrated Study Type Retrospective. Population...
ABSTRACT The purpose of this study was to evaluate the combined effects puerarin (Pue) and insoluble dietary fiber from Hericium erinaceus (HEIDF) on obesity induced by a high-fat diet (HFD) in mice, focusing their lipid glucose metabolism, gut microbiota (GM), serum metabolites. Glucose tolerance, tissue pathology, biochemical levels were conducted assess with Erinaceus (LH) metabolism. 16S rRNA sequencing untargeted metabonomics employed explore underlying mechanisms. results showed that...
Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely unknown. Here, we investigated the of PIK3R1 HCC and examined underlying molecular mechanisms. The expression was evaluated by immunohistochemistry qRT-PCR a series tissues. mRNA protein used western blot assays human lines, then choose MHCC97H HCCLM3 cells as model to investigate effect on...
BACKGROUND Hepatocellular carcinoma (HCC) is the most important cause of cancer-related deaths worldwide. Pirfenidone an orally available small molecule with therapeutic potential for fibrotic diseases. MATERIAL AND METHODS In this study, we analyzed effects different pirfenidone concentrations on proliferation HepG2 HCC cells using Cell Counting Kit-8 (CCK-8) and colony formation assays. Flow cytometry was performed to measure apoptotic cells. Western blot analysis detect expression...
Abstract Background Diabetic retinopathy (DR) is a serious complication of diabetes. Numerous reports have validated that circular RNAs (circRNAs) participate in DR progression. This study aimed to elucidate the role and potential mechanism circRNA zinc finger protein 532 (circZNF532) DR. Methods The levels circZNF532, miR-1243, coactivator associated arginine methyltransferase 1 (CARM1) patients human retinal microvascular endothelial cells (hRMECs) were determined by quantitative real-time...
Abstract Circular RNA (circRNAs) functions vital in the pathogenesis and progression of hepatocellular carcinoma (HCC). However, expressions certain circRNAs on metastasis proliferation that cancer is still unclear. Bioinformation analysis qRT-PCR indicated CircC16orf62 was prominent upregulated HCC which expression level positively associated to cancer’s malignant progression. Gain or loss-of-function studies reduction promotes proliferation, invasion, glycolysis vitro vivo. The...
Medical imaging examination is the primary method of diagnosis, treatment, and prevention cancer. However, amount medical image data often not enough to meet deep learning needs. This article aims expand small set in tumor segmentation based on method.This includes three main parts: cutting mirroring augmentation, augmented images, boundary reconstruction. Firstly, divided into four parts horizontally & vertically, diagonally along tumor's approximate center. Then each part mirrored get a...
Cerebral ischemic injury causes severe brain damage and remains one of the leading morbidity mortality worldwide. Members microRNA-29 (miR-29) family are involved in regulating process ischemia may be developed as biomarkers to diagnose treat cerebral ischemia. The role miR-29b poorly understood. purpose present study was investigate whether overexpression suppressed explore its underlying mechanism action. results demonstrated that levels N2a neuroblastoma cells decreased following oxygen...
The performance of implanted biomaterials is largely determined by their interaction with the host immune system. As a fibrous-like 3D network, fibrin matrix formed at interfaces tissue and material, whose effects on dendritic cells (DCs) remain unknown. Here, bone plates implantation model was developed to evaluate deposition DCs recruitment in vivo. responses were further analyzed 2D vitro. In vivo results indicated that large amount deposited interface between plates, where recruited....
Ellagic acid has been proven to have anticancer, antimutation, antimicrobial and antiviral functions. The present study investigated whether treatment with ellagic was able prevent tetrachloride (CCl4)-induced cirrhosis through the inhibition of reactive oxygen species (ROS) formation angiogenesis. CCl4 diluted in olive oil at a final concentration 10% used induce model. A total 40 mice were random allocated into four groups, as follows: Control, model, 7.5 mg/kg 15 groups. In control group,...
Phospholipase C, β1 (PLCB1) plays critical roles in intracellular transduction and regulating signal activation which are important to tumorigenesis. However, the mechanism of PLCB1 hepatocellular carcinoma (HCC) is still unknown. This study aims investigate whether its expression associated with clinicopathological parameters prognosis patients HCC.Immunohistochemistry on two tissue microarrays containing 141 cases HCC tissues adjacent non-tumorous were performed analyze correlation between...
The present study aimed to determine whether an miRNA (miR)-29b inhibitor protected against cerebral ischemia/reperfusion (I/R) injury in vitro and investigate the underlying mechanisms. As a model for induced IR injury, N2a cells were exposed oxygen-glucose deprivation/reoxygenation (OGD/R) environment. Using this model, it was demonstrated that miR-29b significantly upregulated compared with normal interactions between myeloid cell leukemia sequence (MCL)-1 then investigated using...
Abstract Ischemic cerebral stroke is a leading cause of death and long‐term disability world‐wide. Neuronal injury following ischemia initiates complex series signaling cascades that lead to neuronal cell death. MicroRNA 29b (miR‐29b) has reported involvement in the pathogenic process ischemic brain injury. Dexmedetomidine (Dex) highly selective α 2 adrenergic receptor stimulant exerts protective effect on tissue. To determine whether Dex might directly influence miR‐29b expression after an...
The aim of this study was to evaluate the feasibility transjugular intrahepatic portosystemic shunts using FLUENCY expanded polytetrafluoroethylene (PTFE)‑covered stents and effect on patency rate. A total 114 cirrhotic patients who were treated by stent shunt (TIPS) placement a expanded, PTFE-covered enrolled in present study. Of patients, 15 underwent an additional bare metal implantation portal side covered stent, simultaneously. Patients Doppler sonography during follow-up. Mean venous...
Abstract The mitochondrial malic enzyme 2 (ME2), which is frequently elevated during carcinogenesis and may be a target for cancer therapy, catalyzes the conversion of malate to pyruvate. processes controlling ME2 activity, however, remain largely unclear. In this work, we show that human hepatocellular carcinoma (HCC) tissues contain high levels methylation stimulates growth migration HCC cells. Furthermore, observed interacts with protein arginine methyltransferase 1 (PRMT1) enzymatic...
microRNA (miR)-155 has been demonstrated to participate in the regulation of endothelium during cerebral ischemia. In present study, it was aimed investigate molecular mechanism miR-155 ischemia/reperfusion (I/R) injury with middle artery occlusion (MCAO) mice. The MCAO model established C57BL/6 Transfection mimics and inhibitors performed alter expression miR-155. level measured by RT-qPCR analysis. western blotting results that deletion increased Notch1, intracellular Notch receptor domain...
The incidence and mortality of hepatocellular carcinoma (HCC) are gradually increasing during the past years. Recently, some studies have reported that malic enzyme (ME) plays an important role in cancer development, while involvement ME2 HCC remains still undetermined. Here, we demonstrated played oncogenic HCC. was overexpressed tissues. TCGA database showed transcript level inversely associated with survival patients. Loss-of-function gain-of-function assays promoted cell growth...
Abstract Aim The transjugular intrahepatic portosystemic shunt (TIPS) procedure has been performed in China for 30 years, but our understanding of the status and difficulties associated with use TIPS portal hypertension is incomplete. This study aims to investigate current situation hypertension, which should aid development China. Methods involved a questionnaire survey, initiated by Portal Hypertension Alliance (CHESS) Questionnaires were released on Internet between August 16, 2022...
Intestinal and liver damage caused by low arsenic exposure exists in worldwide, but the pathogenic mechanism is not clear at present.Dictyophora a characteristic edible medicinal fungus China, research has shown that its polysaccharides have good prebiotic effects.Therefore,we explored whether volva polysaccharide from Dictyophora certain therapeutic effect on intestinal hepatic injury exposure.Firstly,we constructed SD rat model of enteritis arsenic-induced.Then, perspectives inflammatory...
BNIP1, a member of the BH3-only protein family, plays essential roles in variety biological processes. However, mechanism and function BNIP1 are still unknown cervical cancer. We aim to explore on cancer cell proliferation, apoptosis, migration, invasion abilities by mTOR signaling pathway.
To develop and test a novel method for automatic quantification of hepatic steatosis in histologic images based on the deep learning scheme designed to predict fat ratio directly, which aims improve accuracy diagnosis non-alcoholic fatty liver disease (NAFLD) with objective assessment severity instead subjective visual estimation.Thirty-six 8-week old New Zealand white rabbits both sexes were fed high-cholesterol, high-fat diet sacrificed under anesthesia at various time points obtain...
PURPOSE We aimed to investigate the safety and tumor seeding rate of a coaxial implantation technique combined with injection gelfoam pellet in establishing VX2 liver model rabbits. METHODS A was established 60 male New Zealand white rabbits, which were randomly divided into 3 groups (20 each group) based on (all performed under ultrasound guidance): group A, single needle only; B, pellet; or C, pellet. The rates formation extrahepatic tissues compared 2 weeks after implantation. Data also...