A5101528764- Histone Deacetylase Inhibitors Research
- Autoimmune Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cervical and Thoracic Myelopathy
- Protein Degradation and Inhibitors
- Spinal Fractures and Fixation Techniques
- Botulinum Toxin and Related Neurological Disorders
- Metal-Organic Frameworks: Synthesis and Applications
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Genetics and Neurodevelopmental Disorders
- Nasolacrimal Duct Obstruction Treatments
- Synthesis and biological activity
- Cerebrovascular and Carotid Artery Diseases
- Advanced oxidation water treatment
- Photochromic and Fluorescence Chemistry
- Trigeminal Neuralgia and Treatments
- Sexual function and dysfunction studies
- Adsorption and biosorption for pollutant removal
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Cancer Mechanisms and Therapy
- Moyamoya disease diagnosis and treatment
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
Nankai University
1996-2025
Hunan Normal University
2023
Affiliated Hospital of Guizhou Medical University
2022
First Affiliated Hospital of Zhengzhou University
2018-2022
Guiyang Medical University
2022
State Key Laboratory of Medicinal Chemical Biology
2016
Chiral 1,4-dihydroquinolines are frequently found in natural products and pharmaceuticals, yet a generally useful route for their synthesis remains elusive. Here, we present an asymmetric partial hydrogenation strategy to access enantioenriched from quinolines. Our involves incorporating ester group at position 3 of the quinoline ring, thereby enhancing electronic deficiency polarity C3–C4 double bond. Employing chiral Ir-SpiroPAP catalyst facilitated wide variety 4-substituted...
A series of novel, highly potent, selective inhibitors targeting both CDK4/9 and HDAC1 have been designed synthesized. N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d] pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide (6e) was discovered. The lead compound 6e with excellent inhibitory activity IC50 = 8.8, 12, 2.2 nM, respectively, can effectively induce apoptosis cancer cell lines. kinase profiling showed selectivity specificity. Compound induces G2/M arrest in high...
Despite initial progress in preclinical models, most known histone deacetylase inhibitors (HDACis) used as a single agent have failed to show clinical benefits nearly all types of solid tumours. Hence, the efficacy HDACis tumours remains uncertain. Herein, we developed hybrid HDAC inhibitor that sensitized HDAC-targeted treatment. Methods: A molecule, Roxyl-zhc-84 was designed and synthesized with novel architecture. The pharmacokinetics toxicity were analysed. antitumour effects on...
To investigate factors that could impact or predict the probability of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis recurrence in central China.From November 2014 to October 2020, observational data anti-NMDAR inpatients our institution were collected and analyzed prospectively. The demographics, clinical characteristics, tumor status, lesion locations on MRI immunotherapies, etc. had entered into a Cox regression model for identification associated with relapse-free survival.We...
Background: Some studies have indicated that a local injection of Botulinum Toxin Type A (BTX-A) is promising therapy for trigeminal neuralgia (TN). However, BTX-A treatment still ineffective approximately 10–43% patients. We therefore investigated which factors are associated with the therapeutic effect in medically refractory, classical TN. Methods: performed retrospective cohort study total 104 patients who were receiving refractory TN between August 2013 and October 2016. VAS score, pain...
Previous research has indicated that the currently available histone deacetylase inhibitors (HDACis) are not effective as monotherapies against oral squamous cell carcinoma (OSCC). However, HDACis act synergistically with other therapeutic agents to exert significant antitumor activities. Thus, a strategy develop chemotherapeutic by combining several active groups based on (HDAC) into single molecule conjugate modulates multiple cellular pathways may be useful for treatment of OSCC.The novel...
PURPOSE We aimed to investigate the safety and tumor seeding rate of a coaxial implantation technique combined with injection gelfoam pellet in establishing VX2 liver model rabbits. METHODS A was established 60 male New Zealand white rabbits, which were randomly divided into 3 groups (20 each group) based on (all performed under ultrasound guidance): group A, single needle only; B, pellet; or C, pellet. The rates formation extrahepatic tissues compared 2 weeks after implantation. Data also...
Abstract Background N-methyl-D-aspartate receptor (NMDAR) and leucine-rich glioma-inactivated 1 (LGI1) antibodies define the most prevalently recognized autoimmune encephalitis syndromes, while simultaneous occurrence of both conditions has hardly been published before. Case presentation We report case a 67-year-old patient who presented with generalized tonic–clonic seizures (GTCS) followed by behavioral changes, psychosis, sleep disorders, decreased consciousness, faciobrachial dystonic...
In order to better develop and utilize curcuminoids, a method with high selectivity simple rapid separation enrichment of curcuminoids from turmeric should be established. this study, hydrated ceria were first prepared, then curcumin was used as model compound investigate the adsorption performance obtained adsorbed materials. Finally, at calcination temperature 400 ºC selected best adsorbent, in effectively separated enriched. This not only has mild synthetic conditions methods for...
We aimed to investigate the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016-2019) were registered prospectively and followed up for 12 months. 96 eligible included study. The modified Rankin scale (mRS) score was collected, 3-6 defined as a poor outcome. equally classified into 3 subgroups based on their FT3 levels obtained within 24 h admission, subgroup differences analyzed by parametric or...
Abstract Objective: To identify the predictors of ischemic events secondary to cervicocerebral artery dissection (CAD). Methods: Consecutive patients with from 2010 2017 were registered as study subjects, who classified and without events. Clinical data collected prospectively, such demographics, vascular risk factors, headache neck pain, site laboratory test. A case-control was performed compare clinical between two groups. Results: total 130 included, in which 70.0% (91/130) suffered...
Abstract Objective : To identify the predictors of ischemic events secondary to cervicocerebral artery dissection (CAD). Methods Consecutive patients with from 2010 2017 were registered as study subjects, who classified and without events. Clinical data collected prospectively, such demographics, vascular risk factors, headache neck pain, site laboratory test. A case-control was performed compare clinical between two groups. Results total 130 included, in which 70.0% (91/130) suffered...
Abstract We aimed to investigate the association between thyroid hormones and functional outcome in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016-2019) were registered prospectively followed up for 12 months. 96 eligible included study. The modified Rankin scale (mRS) score of 3-6 was defined as poor outcome. Logistic regression analysis performed. classified into 3 subgroups based on their free triiodothyronine (fT3) levels,...