A5101704453- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Electrochemical sensors and biosensors
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- Soil Moisture and Remote Sensing
- Precipitation Measurement and Analysis
- Protein Tyrosine Phosphatases
- RNA regulation and disease
- Metal complexes synthesis and properties
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Analytical chemistry methods development
- Molecular Sensors and Ion Detection
- Nanopore and Nanochannel Transport Studies
- ATP Synthase and ATPases Research
- Ferrocene Chemistry and Applications
- Ultrasound and Hyperthermia Applications
- Luminescence and Fluorescent Materials
- Mesoporous Materials and Catalysis
- Curcumin's Biomedical Applications
Nanjing University
2009-2025
Nanjing Drum Tower Hospital
2016-2024
Hunan Normal University
2022-2023
Chengdu University of Information Technology
2023
Dingxi City People's Hospital
2020
First Affiliated Hospital Zhejiang University
2012
Abstract Aims To validate whether the anti‐cancer effect of micro RNA ‐122 ( miR ‐122) on hepatocellular carcinoma HCC ) is mediated through regulating Wnt/β ‐catenin signalling pathways. Methods The expression levels in tissues and varied hepatoma cells were quantified by real‐time PCR . MiR‐122 agomir was transfected into HepG2 , Hep3B to over‐express ‐122. over‐expression proliferation apoptosis evaluated using CCK ‐8 kit flow cytometer respectively. 3′‐ UTR segments Wnt1 containing...
Survivin (encoded by the gene BIRC5) plays an important role in carcinogenesis of bladder cancer. Identifying miRNAs that target setting cancer will help to develop Survivin-based therapies for cancer.The expression levels miR-138-5p and protein were measured 12 resected specimens. The correlation between was further examined evaluating human cell lines either overexpressed or knocked down miR-138-5p. A luciferase reporter assay performed test direct binding BIRC5. We also investigated...
Near-infrared (NIR) light is a promising tool for biomedical imaging and therapy, offering excellent tissue penetration, low scattering, minimal biological fluorescence interference. An NIR-II optical range of 900–1880 nm with reduced background interference particularly useful disease diagnosis treatment. Probes based on organic molecules are gaining attention their structural flexibility stable performance. Organic molecular aggregates, such as J-aggregates, H-aggregates,...
Protein tyrosine phosphatase receptor type G (PTPRG) is an important tumor suppressor gene in multiple human cancers. In this study, we found that PTPRG protein levels were downregulated breast cancer tissues while the mRNA varied irregularly, implying a post-transcriptional mechanism was involved. Because microRNAs are powerful regulators of expression, used bioinformatics analysis to search for potentially targets setting cancer. We identified two specific binding sites miR-19b...
MicroRNAs are known to be generated from primary transcripts mainly through the sequential cleavages by two enzymes, Drosha and Dicer. The sequence of a mature microRNA, especially 'seeding sequence', largely determines its binding ability specificity target mRNAs. Therefore, methods that predict microRNA sequences with high accuracy will benefit identification characterization novel microRNAs their targets, contribute inferring post-transcriptional regulation network at genome scale.We have...
Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a condition causing apnea and hypopnea. LncRNA-ROR revealed properties in regulating hypoxia response. Our study explored the roles of ROR CoCl2-induced injury HK-2 cells. cells were treated with CoCl2 to induce injury. Cell viability, cell apoptosis apoptotic proteins detected using CCK-8, flow cytometry western blot, respectively. The alter expression miR-145 was achieved through transfection. Moreover, expressions HIF-α ERK MAPK...
This study developed a satellite, reanalysis, and gauge data merging model for daily-scale analysis using random forest algorithm in Sichuan province, characterized by complex terrain. A high-precision daily precipitation dataset (MSMP) with spatial resolution of 0.1° was successfully generated. Through comprehensive evaluation the MSMP various indices across different periods regions, following findings were obtained: (1) GPM-IMERG satellite observation exhibited highest performance region...
Ultrasound-targeted microbubble destruction (UTMD) has been found to be an effective method for delivering microRNAs (miRNAs, miRs). The current study is aimed at discovering the potential anti-cancer effects of UTMD-mediated miR-206 on HCC.In our study, expressions and peptidyl-prolyl cis-trans isomerase B (PPIB) in HCC tissues cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR). PPIB adjacent normal analyzed gene expression profiling interactive analysis...
Cancer cells often upregulate ribosome biogenesis to meet increased protein synthesis demands for rapid proliferation; therefore, targeting has emerged as a promising cancer therapeutic strategy. Herein, we introduce two Pt complexes, ataluren monosubstituted platinum(IV) (SPA, formula: c,c,t,-[Pt(NH3)2Cl2(OH)(C15H8FN2O3)], where C15H8FN2O3 = ataluren) and bisubstituted complex (DPA, c,c,t,-[Pt(NH3)2Cl2(C15H8FN2O3)2], ataluren), which effectively suppress by inhibiting 47s pre-RNA...
In order to better develop and utilize curcuminoids, a method with high selectivity simple rapid separation enrichment of curcuminoids from turmeric should be established. this study, hydrated ceria were first prepared, then curcumin was used as model compound investigate the adsorption performance obtained adsorbed materials. Finally, at calcination temperature 400 ºC selected best adsorbent, in effectively separated enriched. This not only has mild synthetic conditions methods for...
The role of siRNAs targeting Survivin and a overexpression plasmid in regulating the proliferative invasive activities bladder cancer cells. (A) Western blotting analysis to detect protein levels T24 cells transfected with Survivin. (B) plasmid. (C) CCK-8 viability assay was performed 12, 24, 36, 48 hours after transfection si-Survivin#1. (D) (E) (F) Transwell invading treated E: representative image; F: quantitative analysis. (G) (H) G: H: *** p
The adsorption and desorption behaviors of cerium oxide nanoparticles (CeO 2 NPs) to triterpene acids were investigated by using closed-ring Lanostane-type open-ring as model compounds. It has been found that the effect structure was better than acids. Under optimal conditions, different types can be separated because their binding abilities on CeO NPs. conformed a pseudo-first-order single-layer after being characterized kinetics thermodynamics. NPs successfully applied enrichment selective...