A5029392163- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Inhalation and Respiratory Drug Delivery
- Renal and related cancers
- Cardiac tumors and thrombi
- Brain Metastases and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Medicinal Plants and Bioactive Compounds
- Nanoplatforms for cancer theranostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Graphene and Nanomaterials Applications
- Noise Effects and Management
- PI3K/AKT/mTOR signaling in cancer
- Traditional Chinese Medicine Analysis
- Protein Kinase Regulation and GTPase Signaling
- Vascular Malformations Diagnosis and Treatment
- Medical Imaging and Pathology Studies
Beijing Friendship Hospital
2017-2024
Capital Medical University
2017-2024
Hangzhou Medical College
2020-2022
Zhejiang Provincial People's Hospital
2020-2022
First Affiliated Hospital of Dalian Medical University
2016
Dalian Medical University
2016
Zhejiang University
2007-2013
Abstract Aims To validate whether the anti‐cancer effect of micro RNA ‐122 ( miR ‐122) on hepatocellular carcinoma HCC ) is mediated through regulating Wnt/β ‐catenin signalling pathways. Methods The expression levels in tissues and varied hepatoma cells were quantified by real‐time PCR . MiR‐122 agomir was transfected into HepG2 , Hep3B to over‐express ‐122. over‐expression proliferation apoptosis evaluated using CCK ‐8 kit flow cytometer respectively. 3′‐ UTR segments Wnt1 containing...
Nonalcoholic steatohepatitis (NASH) is characterized by fat accumulation in the hepatocyte, inflammation, liver cell injury, and varying degrees of fibrosis, can lead to oxidative stress liver. Here, we investigated whether Salidroside, a natural phenolic antioxidant product, protect rat from injury during NASH. NASH model was established feeding male SD rats with high-fat high-cholesterol diet for 14 weeks. Four groups including, normal control group, Salidroside treatment group...
As a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor (VEGFR2-TKI), apatinib has certain anti-tumor effect for variety of solid tumors. The present study evaluates its efficacy and safety in advanced hepatocellular carcinoma (HCC). In this study, 47 patients with HCC were included. TACE monotherapy group included 22 that responded to TACE, while the received 25 progressed on able receive off label. Median overall survival (OS) was significantly improved plus...
Bone metastases are the most common sites for malignant tumors. Patients who failed to respond initial first-line treatment with bisphosphonates usually suffer from extreme pain. The aim of this study was observe efficacy arterial chemoembolization combined Iodine-125 seed implantation in bone metastatic cancer All 14 patients tumor wo underwent day before particles. A computer stereoscopic TPS used design plans, number and dose particles required implantation. Pain relief evaluated using...
Hepatocellular carcinoma (HCC) is widespread cancer with a high degree of morbidity and mortality in individuals worldwide serious concern for its resistance to present chemotherapy drugs. In this investigation, the combination cisplatin (CPT) metformin (MET) kill HepG2 caco-2 cells was developed into new pH-responding magnetic nanocomposite based on reduced graphene oxide. Polyhydroxyethyl methacrylic (PHEA) then linked employing grafting from approach oxide by ATRP polymerization...
patient underwent laparoscopic myomectomy and subsequently developed a fever
Objective: To investigate the clinicopathological characteristics and molecular genetics of atypical renal cysts. Methods: Six cases cysts were collected from Zhejiang Provincial People's Hospital, Hangzhou, China, between February 2014 2019. The disease progression analyzed. 3p deletion trisomy chromosomes 7 17 detected using fluorescence in situ hybridization (FISH). Results: All 6 patients male, aged 43-63 years (median: 52 years). Preoperative Bosniak classification showed 4 grade Ⅱ, 1...
Zeran Yang*, Meihua Ye and Xin Zhang Author Affiliations Department of Pathology, Zhejiang Provincial People’s Hospital, Hospital Hangzhou Medical College, China Received: April 25, 2022 | Published: May 05, Corresponding author: Yang, 158 Shangtang Rd, 310014, China, Email: yangzeran_66@163.com DOI: 10.26717/BJSTR.2022.43.006933
Objective: To detect the clinicopathological features, immunophenotype, diagnosis, and differential diagnosis of composite pheochromocytoma(CP). Methods: Five cases CP were collected at Zhejiang Provincial People's Hospital from January 2011 to 2019. The clinical, radiological, histologic, immunohistochemical outcome data analyzed; discussed. Results: patients' age range was 52-68 years (mean 59 years, median 54 years), There 4 males 1 female, male female ratio 4∶1. Tumor size 3-4 cm 3.6 cm,...
目的： 探讨儿童低度恶性纤维黏液样肉瘤（low grade fibromyxiod sarcoma，LGFMS）的临床病理特征。 方法： 收集2010年1月至2019年1月复旦大学附属儿科医院4例LGFMS，观察其临床、影像学、组织学、免疫组织化学、分子遗传学及预后特征。 结果： LGFMS男女患者各2例，发病年龄3~13岁（平均年龄9岁）；临床表现为缓慢生长的无痛性肿块；典型的形态为黏液样区域和纤维胶原样区域交替性分布，1例局灶区域可见巨菊形团结构；肿瘤细胞表达波形蛋白（4/4）、MUC4（4/4），Ki-67阳性指数5%~20%；荧光原位杂交均可检测到FUS基因的断裂重排；4例均接受手术切除，例2随访71个月后复发。 结论： 儿童LGFMS临床表现不具有特异性，其具有独特的组织学特征，免疫组织化学MUC4阳性表达及FUS基因断裂重排检测有助于其诊断及鉴别诊断。.
Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases colorectal cancer (CRC), we show p53-AP more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated with in overall patients, microsatellite instability (MSI) stable/MSI-low phenotype or distal location. Furthermore, positively lymph node metastasis high TNM stage. Metformin treatment...
To study the expression of tumor associated vascular insulin receptor (TVIR) in colorectal cancer with or without metabolic syndrome (MS) and its relationship pathological features cancer.The TVIR 220 specimens was detected by tissue microarray immunohistochemistry. The relationships between (pathological subtypes, histological grade, invasion depth, lymph node metastasis TNM stage) with/without MS were analyzed.The observed border area normal tissue, but not intestinal tissue....
Abstract Background Previous study has suggested a link between diabetes and colorectal cancer (CRC), but the specific molecule for not been well-understood. Abnormal p53 immunohistochemical (IHC) pattern is an accurate predictor TP53 gene mutation. The present aimed to investigate relationship type 2 mellitus (T2DM) IHC patterns in CRC. Methods We analyzed protein expression of 742 cases CRC with radical colectomy by immunohistochemistry. patients were grouped into subsets non-diabetes (n =...