A5101976432- Renal cell carcinoma treatment
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Pituitary Gland Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Dental materials and restorations
- Polyamine Metabolism and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Mast cells and histamine
- Ferroptosis and cancer prognosis
- Liver physiology and pathology
Children's Hospital of Zhejiang University
2022-2025
Jiangxi Agricultural University
2024
Zunyi Medical University
2024
Second Affiliated Hospital of Zhejiang University
2023-2024
Xinqiao Hospital
2023
Army Medical University
2020-2023
Capital Medical University
2023
Zhejiang University
2022-2023
Xiamen Medical College
2021-2023
Beijing Chao-Yang Hospital
2023
Survivin (encoded by the gene BIRC5) plays an important role in carcinogenesis of bladder cancer. Identifying miRNAs that target setting cancer will help to develop Survivin-based therapies for cancer.The expression levels miR-138-5p and protein were measured 12 resected specimens. The correlation between was further examined evaluating human cell lines either overexpressed or knocked down miR-138-5p. A luciferase reporter assay performed test direct binding BIRC5. We also investigated...
We compared outcomes in patients treated with radio frequency ablation or partial nephrectomy for clinical cT1b renal cell carcinoma.We retrospectively reviewed the records of all who underwent between February 2006 and December 2010. Radiographic followup contrast imaging was performed 7 days, 3 6 months, every months thereafter after sequentially. The protocol initial years annually thereafter. Kaplan-Meier method used to generate survival curves, which were log rank test. Multivariable...
Introduction: To evaluate the diagnostic accuracy of uroflowmetry in detecting pediatric urethral strictures following Tubularized Incised-Plate (TIP) and non-TIP urethroplasty. Materials Methods: A retrospective cohort study was conducted on children who underwent primary hypospadias repairs from June 2016 to 2023 at our institution. Patients were categorized into TIP groups. Urethral calibration used patency Data demographic characteristics, perioperative information, results, outcomes,...
This study aimed to evaluate the medium and long-term outcomes of tunneled labial mucosa tube graft urethroplasty in treatment primary severe hypospadias failed hypospadias. We retrospectively reviewed medical records patients who underwent at a single center between 2007 2020. Data collected included patient demographic, operative post-operative characteristics. The surgical procedure was performed two stages. Binary logistic regression model used identify risk factors for postoperative...
Abstract Acute kidney injury (AKI) remains challenging for clinical practice and poses a risk of developing progressive chronic disease (CKD) with no definitive treatment available yet. Tanshinone IIA, an active ingredient Chinese herbal Salvia miltiorrhiza , has been widely used in Asia the remarkable organoprotective activities. Its effect on established AKI, however, unknown. In mice folic acid-induced delayed commenced early or late after injury, diminished renal expression markers,...
Vitamin E intake has been implicated in reduction of bladder cancer risk. However, the mechanisms remain elusive. Here we reported that δ-tocotrienol (δ-T3), one vitamin isomers, possessed most potent cytotoxic capacity against human cells, compared with other isomers. δ-T3 inhibited cell proliferation and colonogenicity through induction G1 phase arrest apoptosis. Western blotting assay revealed increased expression levels cycle inhibitors (p21, p27), pro-apoptotic protein (Bax) suppressed...
Human MTP18 (mitochondrial protein 18 kDa) is a novel nuclear-encoded mitochondrial membrane that involved in controlling fission. Our bioinformatic analysis of TCGA data revealed an aberrant overexpression hepatocellular carcinoma (HCC). We analyzed its biological effects and prognostic significance this malignancy.MTP18 expression was evaluated by qRT-PCR western blot 20 paired tumor peritumor tissues. Clinical impact assessed 156 patients with HCC. The knockdown or on cell growth...
<b><i>Background:</i></b> Fatty liver disease (FLD) has become a rampant condition. It is associated with high rate of morbidity and mortality in population. The condition commonly referred as FLD. Early prediction FLD would allow patients to take necessary preventive, diagnosis, treatment. main objective this research develop machine learning (ML) model predict that can help medics classify individuals at risk FLD, make novel management, prevention for...
Tanshinone IIA is a diterpene extracted from Salvia miltiorrhiza, popular and safe herb medicine that has been widely used in China other Asian countries. Previous studies have demonstrated the pleiotropic effects of on many disease treatments via its antitoxicity, anti-inflammation, anti-oxidative stress, as well antifibrosis activities. However, effect acute kidney injury (AKI) not fully investigated. Here, we show for first time systemic administration can lead to improved function folic...
Background Renal cell carcinoma (RCC) was sex-hormone responsive, and clinical trials using progesterone significantly reduced the incidence of distal metastasis after radical nephrectomy. Recently membrane-bound receptors (mPRs) were discovered to mediate non-genomic effect progesterone. Aberrant expressions these mPRs reported in human breast, ovarian, urinary bladder, brain, uterine, prostate cancers. However, their expression profiles RCC are yet be assessed. Methods Multiple datasets...
The aim of this study was to assess the functional and oncologic outcomes percutaneous radiofrequency ablation (RFA) with contrast-enhanced ultrasonography (CEUS) for renal cell carcinoma in patient autosomal dominant polycystic kidney. We performed a retrospective review five patients (RCC) kidney disease (ADPKD) from January 2009 December 2014 media follow-up 33 months. tumors were ablated Cool-tip RFA system under guidance CEUS. Routine included computed tomography/magnetic resonance...
To assess the functional and oncologic outcomes of laparoscopic radiofrequency ablation (RFA) with intraoperative contrast-enhanced ultrasonography in treatment T1b renal tumors.We performed a retrospective review 51 patients unilateral tumors who underwent RFA from January 2007 to April 2012 mean follow-up 31.5 months. The were laparoscopically dissected ablated cool-tip system under guidance ultrasound. Routine included computed tomography/magnetic resonance imaging (CT/MRI) function...
The aim of this study was to assess the photodynamic effect nanoparticles loaded with a photosensitizing nanomedicine, 5-aminolevulinic acid (5-ALA), on T24 bladder cancer cells in vitro.The nanoprecipitation technique successfully used prepare drug-loaded polymeric nanoparticles. drug loading rate and efficiency were determined by ultraviolet spectrophotometry. size morphology detected using dynamic light scattering (DLS) transmission electron microscopy. Cytotoxicity assessed coincubating...