A5062204083- Cancer Mechanisms and Therapy
- Ion Channels and Receptors
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Thermoregulation and physiological responses
- Neuropeptides and Animal Physiology
- Berberine and alkaloids research
- Caveolin-1 and cellular processes
- Boron Compounds in Chemistry
- Nanoparticle-Based Drug Delivery
- Bioactive natural compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Biological Activity of Diterpenoids and Biflavonoids
- Antifungal resistance and susceptibility
- PARP inhibition in cancer therapy
- Metabolism, Diabetes, and Cancer
- ATP Synthase and ATPases Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver physiology and pathology
- Medical Imaging and Pathology Studies
- Quinazolinone synthesis and applications
- Biochemical effects in animals
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
Shaanxi Provincial People's Hospital
2016-2021
Shanxi Medical University
2016-2021
Kyushu University
2018-2020
Fukuoka Dental College
2020
Shaanxi Provincial People's Hospital
2018
Lanzhou University
2010
Army Medical University
2009
Human MTP18 (mitochondrial protein 18 kDa) is a novel nuclear-encoded mitochondrial membrane that involved in controlling fission. Our bioinformatic analysis of TCGA data revealed an aberrant overexpression hepatocellular carcinoma (HCC). We analyzed its biological effects and prognostic significance this malignancy.MTP18 expression was evaluated by qRT-PCR western blot 20 paired tumor peritumor tissues. Clinical impact assessed 156 patients with HCC. The knockdown or on cell growth...
Dicranostigma Leptopodum (Maxim) Fedde (DL- F), which had been previously documented to suppress oxidative hemolysis of erythrocytes and enhance immune functions murine peri- toneal macrophages, was investigated for its effect on anti-tumor activity. Of alkaloids extracted from DLF, five have identified with employment chromatographic analysis. An antiproliferative role these determined SMMC-7721 Human Hepatoma Ce- lls in an apoptosis-inducing manner, through MTT assaying, Trypan blue...
Abstract Transient receptor potential vanilloid 1 (TRPV1), a nociceptive cation channel, is known to play roles in regulating the energy metabolism (EM) of whole body. We previously reported that TRPV1 antagonists such as AMG517 enhanced EM mice, however, these mechanisms remain unclear. The aim this study was explore underlying enhancement by AMG517, selective antagonist, mice. Respiratory gas analysis indicated intragastric administration along with increasing locomotor activity Next,...
Objective: To investigate the regulatory role of HK2 in metastasis hepatocellular carcinoma (HCC). Methods: The protein expressions 73 HCC tumor tissues and paired adjacent non-tumor were evaluated by using immunohistochemical analysis. scratch wound healing assay Transwell had been used to analyze migration invasion cells with knockdown. Expressions epithelial-to-mesenchymal transition (EMT)markers, such as E-cadherin, ZO-1, N-cadherin vimentin, knockdown determined qRT-PCR Western blot...
Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive cation channel that activated by heat, protons and chemical ligands such as capsaicin. We investigated the roles of capsaicin receptor, TRPV1, in controlling energy metabolism whole body. It has been reported activation TRPV1 its agonists enhances metabolism. In this study, we used respiratory gas analysis system to examine whether inhibition changes mice. addition, examined contributions different modes (heat, capsaicin)...
Objective To investigate the correlation between α1-adrenergic receptor and pathological behavior of cholangiocarcinoma, effects norepinephrine (NE) on proliferation cholangiocarcinoma cell line QBC939. Methods Thirty-six samples were resected in Southwest Hospital from August 2002 to March 2008. The expression 36 tissue 4 normal bile duct detected by SABC technique. cholangio-carcinoma QBC939 was after processing cells with NE, phentolamine prazosin. All data analyzed chi-square test....
Objective To investigated the effect of AngiotensinⅡ(AngⅡ) on proliferation and apoptosis hepatic stellate cells (HSCs) LX2 by targeting Notch1. Methods The AngⅡ HSCs was detected CCK8. The AngII collagen synthesis ability hydroxyproline acid method. Notch1 low expression cell model constructed transfecting siRNA-Notch1 with liposome. induced knockdown protein in Western Blot. All test results were biologically replicated. Statistical analysis performed using variance t-test....