A5078539903- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Tissue Engineering and Regenerative Medicine
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Hormonal and reproductive studies
- Galectins and Cancer Biology
- Cholesterol and Lipid Metabolism
- Educational Reforms and Innovations
- Prostate Cancer Diagnosis and Treatment
- Competency Development and Evaluation
- Liver Diseases and Immunity
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Plant Toxicity and Pharmacological Properties
- Aldose Reductase and Taurine
- Cancer Cells and Metastasis
- Higher Education Learning Practices
Model Animal Research Center
2018-2024
Nanjing University
2018-2024
Pudong Medical Center
2022-2024
Fudan University
2022-2024
Qiqihar Medical University
2014-2022
Tianjin Hi-Tech Superconducting Electronic Technology (China)
2022
Artificial Intelligence in Medicine (Canada)
2022
Nanchang University
2020
Xijing University
2019
Liaoning Meteorological Bureau
2018
Abstract Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME) are indispensable for maintenance CSCs. To better understand mechanisms involved TME-mediated generation support UBC CSCs, we focused on role cancer-associated fibroblasts (CAF) this study. Overexpression miR-146a-5p CAFs promoted...
Abstract The chromobox (CBX) proteins mediate epigenetic gene silencing and have been implicated in the cancer development. By analyzing eight CBX family members TCGA dataset, we found that 7 (CBX7) was most strikingly downregulated member urinary bladder (UBC), as compared to normal tissues. Though dysregulation of CBX7 has reported multiple cancers, its specific role clinical relevance UBC remain unclear. Herein, frequent downregulation specimens, which due promoter hypermethylation,...
Abstract Hypercholesterolemia is a prevalent metabolic disorder that has been implicated in the development of steroid-targeted cancers. However, link between hypercholesterolemia and urinary bladder cancer (UBC), non–steroid-targeted cancer, remains unresolved. Here we show diet-induced Ldlr deficiency–induced enhances both UBC stemness progression. Inhibition intestinal cholesterol absorption by ezetimibe reversed stemness. As key component hypercholesterolemic sera, oxidized low-density...
Aberrant sialylation is frequently observed in tumor development, but which sialyltransferases are involved this event not well known. Herein, we performed comprehensive analyses on six ST3GAL family members, the α-2,3 sialyltransferases, clear cell renal carcinoma (ccRCC) from public datasets. Only ST3GAL5 was consistently and significantly overexpressed ccRCC (n = 791 total), compared with normal kidney tissues. Its overexpression positively correlated stage, grade, poor prognosis...
Abstract Benign prostatic hyperplasia (BPH) is one of the most common diseases in urinary system elderly men. Pao extract an herbal preparation bark Amazon rainforest tree Pereira ( Geissospermum vellosii ), which was reported to inhibit prostate cancer cell proliferation. Herein we investigated therapeutic potential against BPH development a testosterone-induced rat model. The administration testosterone induced enlargement, compared with sham operated group vehicle treatment. BPH/Pao...
Ten-eleven translocation 1 (TET1) is a member of methylcytosine dioxygenase, which catalyzes 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine hmC) promote the demethylation process. The dysregulated TET1 protein and 5 hmC level were reported either suppress or carcinogenesis in cancer type-dependent manner. Currently, role development urinary bladder (UBC) its underlying molecular mechanisms remain unclear. Herein, we found that expression was downregulated UBC specimens compared with...
Cancer cells are intimately intertwined with tumor microenvironment (TME), fostering a symbiotic relationship propelling cancer progression. However, the interaction between and tumor-associated macrophages (TAMs) in urothelial bladder (UBC) remains poorly understood.
ST6GALNAC family members function as sialyltransferases and have been implicated in cancer progression. However, their aberrant expression levels, prognostic values specific roles metastatic prostate (PCa) remain largely unclear.Two independent public datasets (TCGA-PRAD GSE21032), containing 648 PCa samples total, were employed to comprehensively examine the mRNA changes of PCa, well associations with clinicopathological parameters prognosis. The dysregulation ST6GALNAC5 was further...
<p>Supplementary Data</p>
<div>Abstract<p>Cancer stem-like cells (CSCs) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME) are indispensable for maintenance CSCs. To better understand mechanisms involved TME-mediated generation support UBC CSCs, we focused on role cancer-associated fibroblasts (CAFs) this study. Overexpression miR-146a-5p...
<p>Supplementary Data</p>
<div>Abstract<p>Cancer stem-like cells (CSCs) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME) are indispensable for maintenance CSCs. To better understand mechanisms involved TME-mediated generation support UBC CSCs, we focused on role cancer-associated fibroblasts (CAFs) this study. Overexpression miR-146a-5p...
<p>Supplementary Data</p>
Intuitionistic fuzzy number, which is an extension of has been applied in many fields as it considers membership degree and non-membership degree. However, some circumstances, intuitionistic number does not express uncertainty vagueness well. In order to deal with this p roblem, a new concept trapezoidal type-2 number(TrT2IFN) proposed paper. Meanwhile, the arithmetical operations TrT2IFNs are defined. Then, novel distance measures by taking advantage Hausdorff distance. Additionally,...
Objective To explore the nursing occupational quality and ability of school-based curriculum development practice improve comprehensive nurses continually. Methods We surveyed set up leading group, wrote outline teaching design, compiled materials organized activities. Results In 2010, students in Grade Three had to chose this course as compulsory course. Over four years since developed 'Occupational competence’, 378 (94.5%) total 400 participated study believed was necessary...
<p>Supplementary Materials and Methods, Figures Tables</p>
<p>Supplementary Materials and Methods, Figures Tables</p>
<div>Abstract<p>Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME) are indispensable for maintenance CSCs. To better understand mechanisms involved TME-mediated generation support UBC CSCs, we focused on role cancer-associated fibroblasts (CAF) this study. Overexpression miR-146a-5p CAFs...
<div>Abstract<p>Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME) are indispensable for maintenance CSCs. To better understand mechanisms involved TME-mediated generation support UBC CSCs, we focused on role cancer-associated fibroblasts (CAF) this study. Overexpression miR-146a-5p CAFs...
<p>Supplementary Data</p>
<p>Supplementary Data</p>