A5100333833- Advanced biosensing and bioanalysis techniques
- Vector-Borne Animal Diseases
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
- Animal Disease Management and Epidemiology
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Viral Infections and Vectors
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Extracellular vesicles in disease
- Microbial infections and disease research
- Probiotics and Fermented Foods
- Escherichia coli research studies
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Genetic factors in colorectal cancer
- Bacterial Genetics and Biotechnology
- Cancer Research and Treatments
- Antimicrobial Peptides and Activities
Northeast Agricultural University
2017-2025
Yuhuangding Hospital
2024-2025
Second Hospital of Shandong University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Guangdong Academy of Medical Sciences
2023-2025
Southern Medical University
2023-2025
Shandong Provincial Hospital
2022-2025
Shandong University
2022-2025
Shandong First Medical University
2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
Background: Preeclampsia is one of the leading causes maternal and perinatal morbidity characterized by hypertension, inflammation, placental dysfunction. Gut microbiota plays key roles in inflammation hypertension. However, its mechanisms preeclampsia have not been fully elucidated. Methods: 16S rRNA gene sequencing targeted metabolomics were conducted on stool samples from 92 preeclamptic patients 86 normal late-pregnant women. Then, fecal transplantation vitro vivo functional experiments...
Graves' Disease (GD) is a thyroid-specific autoimmune disease and the most common cause of hyperthyroidism. Its pathogenesis associated with disruption immune tolerance autoantibody production. However, mechanisms underlying abnormalities remain incompletely elucidated. We employed single-cell RNA sequencing (scRNA-seq) analyzed 22680 peripheral blood mononuclear cells (PBMCs) from eight GD patients twelve healthy controls. Our results unveiled landscape PBMCs in patients, revealing...
The sudden outbreak and worldwide spread of monkeypox suggests an urgent demand for more effective on-site diagnostic technology to counter the silent highly pathogenic virus. This paper reports a dual-signal readout immunochromatography assay (ICA) with colorimetric–fluorescence co-enhanced ability ultrasensitive flexible detection virus (MPXV) antigen in different scenarios. A two-dimensional film-like nanotag molybdenum disulfide (MoS2) core multilayered quantum dot (QD) shells was...
The primary aim of this study was to evaluate the efficacy phage against mastitis induced by drug-resistant S. aureus in a mouse model. In study, five phages—4086-1, 4086-2, 4086-3, 4086-4, and 4086-6—were isolated from milk samples secreted cows. Transmission electron microscopy showed that all phages had icosahedral heads short non-contractile tails, which are typical characteristics family Podoviridae. All these were species-specific aureus. one-step growth curve latency period (10–20...
Cancer cells are intimately intertwined with tumor microenvironment (TME), fostering a symbiotic relationship propelling cancer progression. However, the interaction between and tumor-associated macrophages (TAMs) in urothelial bladder (UBC) remains poorly understood.
Cell division cycle 23 (CDC23) is a component of the tetratricopeptide repeat (TPR) subunit in anaphase-promoting complex or cyclosome (APC/C) complex, which participates regulation mitosis eukaryotes. However, regulatory model and mechanism by CDC23 gene regulates muscle production pigs are largely unknown. In this study, we investigated expression pigs, results indicated that widely expressed various tissues organs. vitro cell experiments have demonstrated promotes proliferation myoblasts,...
Sialylation aberration has been implicated in lung cancer development by altering signaling pathways. Hence, it is urgent to identify key sialyltransferases the of adenocarcinoma (LUAD), which a common malignant subtype non-small cell cancer. Herein, systematically investigating expression levels ST3GAL family members several public databases, we consistently found frequent downregulation ST3GAL6 LUAD samples. Its significantly negatively associated with stage, and reduced...
Foot-and-mouth disease virus (FMDV) and Senecavirus A (SVA) have similar pathogenic characteristics, both are important pathogens that harm the livestock industry. Studies shown lactoferrin peptides can inhibit replication of various viruses enhance body’s immune functions. Based on this, in present study, we aimed to investigate effects bovine lactoferricin-lactoferrampin (LFCA) replicating FMDV SVA analyze its role cellular antioxidant response caused by viral infection; addition, fed mice...
The treatment of infections caused by drug-resistant Staphylococcus aureus has become increasingly difficult. In this study, the complete genome phage 4086-1 against S. was sequenced and shown to be 17,960 bp in size, with a GC content 29.14%. Phylogenetic analysis demonstrated that exhibited close relationship phages SLPW, JPL-50, LSA2366. BLAST indicated ORF12 (termed Hol-4086) shares high identity other reported phage-associated holins. Hol-4086 consists 140 amino acids exhibits sequence...
Purpose Abnormal expression of PINCH-1 has been observed in various types human cancers. However, the clinical importance and mechanism underlying its role head neck squamous cell carcinoma (HNSCC) is yet to be fully elucidated.
ABSTRACT Porcine epidemic diarrhea virus (PEDV) causes severe intestinal damage and high mortality in neonatal piglets. The continuous emergence of new strains has brought challenges to prevention control. In this study, we isolated characterized a prevalent PEDV virulent strain analyzed 19,612 jejunal cells from PEDV-infected control piglets using single-cell sequencing, revealing significant changes cellular composition, gene expression, intercellular communication. response infection,...
Herein, fluorescent gold nanoclusters (AuNCs) and horseradish peroxidase (HRP) were simultaneously embedded into self-assembled dipeptide supramolecular films of N-fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF) on the surface ITO electrodes (Fmoc-FF/AuNCs/HRP) by using a simple single-step process. In films, both fluorescence property AuNCs bioelectrocatalytic HRP well maintained could be reversibly regulated pH-sensitive structural changes in Fmoc-FF hydrogel films. Cu(II)/EDTA solution...
Hepatitis-hydropericardium syndrome (HHS) is a highly fatal disease in chickens caused by the pathogenic fowl adenovirus serotype 4 (FAdV-4), which has severe economic consequences. The fiber2 protein exhibits excellent potential as candidate for subunit vaccination against FAdV-4. Despite having high safety profile, vaccines have low immunogenicity due to their lack of infectivity, leads levels immune response. As vaccine adjuvant, Salmonella flagellin possesses augment immunological...
Infectious bursal disease virus (IBDV) causes immunosuppression and high mortality in young chickens. Long non-coding RNAs (lncRNAs) microRNAs (miRNAs) are important regulators during viral infection. However, detailed the regulatory mechanisms of lncRNA-miRNA-mRNA have not yet been described IBDV Here, we analysed role lncRNA53557/gga-miR-3530-5p/STAT1 axis very virulent (vvIBDV) Evidently upregulated expression lncRNA53557 was observed bursa Fabricius DT40 cells. Meanwhile, overexpression...
Abstract Rapid, sensitive, and accurate detection of respiratory pathogens is essential yet challenging. Here, this study presents a universal nanozyme immunochromatographic assay (ICA) that utilizes the broad binding capacity 4‐mercaptophenylboronic acid (MPBA) for glycosylated molecules on bacterial viral surfaces, along with colorimetric‐catalytic dual enhancement capability multi‐tentacle magnetic (FeAu@AuIr), to achieve ultrasensitive, wide‐range, simultaneous multiple pathogens. The...
Dendritic cells (DCs) play a key role in the natural recognition of pathogens and subsequent activation adaptive immune responses due to their potent antigen-presenting ability. cell-targeting peptide (DCpep) is strongly targeted DCs, which often express antigens, enhance efficacy vaccines. Our previous study showed that recombinant Lactobacillus expressing human DCpep could significantly induce stronger than without DCpep, but mechanism remains unclear. In this study, by enhances response...
Myogenic differentiation is a complex biological process that regulated by multiple factors, among which long noncoding RNAs (lncRNAs) play an essential role. However, in-depth studies on the regulatory mechanisms of in myogenic are limited. In this study, we characterized role novel lncRNA TCONS_00323213, upregulated during porcine skeletal muscle satellite cell (PSC) myogenesis. We found TCONS_00323213 affected proliferation and PSC vitro. performed quantitative polymerase chain reaction...