A5100621611- RNA modifications and cancer
- Galectins and Cancer Biology
- Gastrointestinal motility and disorders
- Advanced Nanomaterials in Catalysis
- 3D Surveying and Cultural Heritage
- Renal Diseases and Glomerulopathies
- Intensive Care Unit Cognitive Disorders
- Ferroptosis and cancer prognosis
- Anesthesia and Neurotoxicity Research
- Biological Activity of Diterpenoids and Biflavonoids
- Tactile and Sensory Interactions
- Endoplasmic Reticulum Stress and Disease
- Biosensors and Analytical Detection
- Auction Theory and Applications
- S100 Proteins and Annexins
- Medicinal plant effects and applications
- Nanocluster Synthesis and Applications
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Multimedia Communication and Technology
- Aquaculture disease management and microbiota
- Diverse Scientific Research in Ukraine
- Cancer Genomics and Diagnostics
Minhang District Central Hospital
2022-2025
Fudan University
2022-2025
State Key Laboratory of Food Science and Technology
2023-2024
Jiangnan University
2019-2024
Hunan Normal University
2024
Shanghai University of Traditional Chinese Medicine
2023
Shenzhen Children's Hospital
2023
Wuhan Children's Hospital
2023
Huazhong University of Science and Technology
2023
Hangzhou Medical College
2023
Building multifunctional platforms for integrating the detection and control of hazards has great significance in food safety environment protection. Herein, bimetallic Fe–Co-based metal–organic frameworks (Fe–Co-MOFs) peroxidase mimics are prepared applied to develop a bifunctional platform synergetic sensitive controllable degradation aflatoxin B1 (AFB1). On one hand, Fe–Co-MOFs with excellent peroxidase-like activity combined target-induced catalyzed hairpin assembly (CHA) construct...
ABSTRACT Background Immunoglobulin A nephropathy (IgAN) is a major cause of primary glomerulonephritis characterized by mesangial deposits galactose-deficient IgA1 (Gd-IgA1). Toll-like receptors (TLRs), particularly TLR4, are involved in the pathogenesis IgAN. The role gut microbiota on IgAN patients was recently investigated. However, whether microbial modifications Gd-IgA1 through TLR4 play remains unclear. Methods We recruited subjects into four groups, including 48 with untreated IgAN,...
Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerular disease in adults worldwide. Several studies have reported that galactose-deficient IgA1 (Gd-IgA1) involved pathogenesis IgAN.Thirty-five patients with IgAN diagnosed renal biopsy for first time served as experimental group, who were hospitalized our department. Twenty normal healthy cases physical examination center hospital control group. Then levels Gd-IgA1 serum and urine, intestinal mucosal barrier injury...
Aberrant sialylation is frequently observed in tumor development, but which sialyltransferases are involved this event not well known. Herein, we performed comprehensive analyses on six ST3GAL family members, the α-2,3 sialyltransferases, clear cell renal carcinoma (ccRCC) from public datasets. Only ST3GAL5 was consistently and significantly overexpressed ccRCC (n = 791 total), compared with normal kidney tissues. Its overexpression positively correlated stage, grade, poor prognosis...
Sialylation aberration has been implicated in lung cancer development by altering signaling pathways. Hence, it is urgent to identify key sialyltransferases the of adenocarcinoma (LUAD), which a common malignant subtype non-small cell cancer. Herein, systematically investigating expression levels ST3GAL family members several public databases, we consistently found frequent downregulation ST3GAL6 LUAD samples. Its significantly negatively associated with stage, and reduced...
Alzheimer's disease (AD) is a devastating in the elderly with no known effective treatment. It characterized by progressive deterioration of memory and cognition. Many new potential targets are being investigated to develop therapeutic strategies for AD. Neuropeptide S (NPS) an endogenous peptide central nervous system, which has been shown play beneficial role learning memory. However, whether NPS can ameliorate cognitive deficits AD remains unclear. In this study, we examined effects...
Postoperative cognitive dysfunction (POCD) is a major clinical complication after surgery under general anesthesia, particularly in elderly patients, but the mechanisms remain unclear. We recently found that anaesthetization of aging C57BL/6 J mice (14–16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce and synaptic plasticity deficits. Further studies demonstrated induced ANP32A (acidic leucine-rich nuclear phosphoprotein-32A) overexpression by...
The stunning qualitative improvement of recent text-to-image models has led to their widespread attention and adoption. However, we lack a comprehensive quantitative understanding capabilities risks. To fill this gap, introduce new benchmark, Holistic Evaluation Text-to-Image Models (HEIM). Whereas previous evaluations focus mostly on text-image alignment image quality, identify 12 aspects, including alignment, aesthetics, originality, reasoning, knowledge, bias, toxicity, fairness,...
Babesiosis caused by Babesia microti parasite is an emerging tick borne zoonotic disease that was confirmed recently in China. To understand the epidemiology characteristics of this disease, infectivity B. to domestic animals and ticks outside genus Ixodes evaluated study. Different animals, chick, pig, goat, dog reference host rat were experimentally inoculated with microti-infected erythrocytes infection monitored daily blood smear observation, real-time PCR detection, nested-PCR special...
Human-designed visual manuals are crucial components in shape assembly activities. They provide step-by-step guidance on how we should move and connect different parts a convenient physically-realizable way. While there has been an ongoing effort building agents that perform tasks, the information human-design largely overlooked. We identify this is due to 1) lack of realistic 3D objects have paired 2) difficulty extracting structured from purely image-based manuals. Motivated by...
Abstract Thyroid cancer is the endocrine tumor with highest incidence at present. It originates from thyroid follicular epithelium or paraepithelial cells. There an increasing of all over world. We found that SRPX2 expression level was higher in papillary tumors than normal tissues, and closely related to grade clinical prognosis. Previous reports showed could function by activating PI3K/AKT signaling pathway. In addition, vitro experiments promoted proliferation migration (PTC). conclusion,...
There is the ongoing debate over effect of inspired oxygen fraction (FiO2) during mechanical ventilation on postoperative atelectasis. We aimed to compare effects low (30%) and moderate (60%) FiO2 The hypothesis study was that 30% could reduce atelectasis volume compared with 60% FiO2.We performed a randomized controlled trial 120 patients. Subjects were randomly assigned receive or in 1:1 ratio. primary outcome percentage total lung measured using chest CT within 30 min after extubation....
Humans use all of their senses to accomplish different tasks in everyday activities. In contrast, existing work on robotic manipulation mostly relies one, or occasionally two modalities, such as vision and touch. this work, we systematically study how visual, auditory, tactile perception can jointly help robots solve complex tasks. We build a robot system that see with camera, hear contact microphone, feel vision-based sensor, three sensory modalities fused self-attention model. Results...
Growing evidence suggests that macroautophagy/autophagy-lysosomal pathway deficits contribute to the accumulation of amyloid-β (Aβ) in Alzheimer disease (AD). Aerobic exercise (AE) has long been investigated as an approach delay and treat AD, although exact role mechanism are not well known. Here, we revealed AE could reverse autophagy-lysosomal via activation ADRB2/β2-adrenergic receptor, leading significant attenuation pathology APP-PSEN1/PS1 mice. Molecular research found autophagy by...
Introduction Bone metastasis (BoM) occurs when cancer cells spread from their primary sites to a bone. Currently, the mechanism underlying this process remains unclear. Methods In project, through an integrated analysis of bulk-sequencing and single-cell RNA transcriptomic data, we explored BoM-related features in tumor microenvironments different tumors. Results We first identified 34 up-regulated genes during BoM breast cancer, further expression status among components microenvironment...
We propose 3D Congealing, a novel problem of 3D-aware alignment for 2D images capturing semantically similar objects. Given collection unlabeled Internet images, our goal is to associate the shared semantic parts from inputs and aggregate knowledge canonical space. introduce general framework that tackles task without assuming shape templates, poses, or any camera parameters. At its core representation encapsulates geometric information. The optimizes together with pose each input image,...
Training robot policies in the real world can be unsafe, costly, and difficult to scale. Simulation serves as an inexpensive potentially limitless source of training data, but suffers from semantics physics disparity beween simulated real-world environments. These discrepancies minimized by digital twins,which serve virtual replicas a scene are expensive generate cannot produce cross-domain generalization. To address these limitations, we propose concept cousins, asset or that, unlike...
Aims: The aim of this study was to investigate the role human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exo) in regulating intestinal type 2 immune response for either protection or therapy. Background: hUCMSC-Exo considered a novel cell-free therapeutic product that shows promise treatment various diseases. Type immunity is protective classified as T-helper (Th2) cells and associated with helminthic infections allergic effect on not clear. Method: C57BL/6 mice were used...
<title>Abstract</title> To investigate the role and mechanisms of intestinal microbiota in hyperuricemia-induced renal injury, failure models were established using unilateral nephrectomized mice. Following four weeks a diet supplemented with adenine potassium oxalate, probiotic intervention was implemented. H&E staining plasma biochemical assessments employed to monitor pathological functional alterations. Changes metabolites analyzed through fecal microbial 16S rRNA gene sequencing...
Kidney transplantation (KT) has surpassed dialysis as the optimal therapy for end-stage kidney disease. Yet, most patients could suffer from a slow but continuous deterioration of function leading to graft loss mostly due chronic allograft nephropathy (CAN) after KT. The dysregulated gene expression CAN is still poorly understood.To explore pathogenesis genomics in CAN, we analyzed differentially expressed genes (DEGs) transcriptome between and nonrejecting by downloading microarrays Gene...