A5022089109- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Salivary Gland Tumors Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Eating Disorders and Behaviors
- Ultrasound and Hyperthermia Applications
- Eosinophilic Disorders and Syndromes
- Problem and Project Based Learning
- Neonatal Respiratory Health Research
- Hedgehog Signaling Pathway Studies
- Adipose Tissue and Metabolism
- Trigeminal Neuralgia and Treatments
- Ultrasound in Clinical Applications
- Healthcare and Venom Research
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle and Compartmental Disorders
- Medicinal Plants and Bioactive Compounds
- Genomics and Rare Diseases
- TGF-β signaling in diseases
- Eosinophilic Esophagitis
Nanjing Drum Tower Hospital
2010-2024
Nanjing University of Chinese Medicine
2024
Nanjing Medical University
2018-2022
Sichuan Cancer Hospital
2022
First Affiliated Hospital of Harbin Medical University
2008-2021
Harbin Medical University
2008-2021
Harbin University
2020
Hangzhou First People's Hospital
2011-2019
Zhejiang University
2019
Zhejiang Chinese Medical University
2018
Recent studies have indicated the possibility that genistein may improve depression via regulating expression of miR221/222. This study is to explore whether could by altering miR-221/222 levels and investigate possible mechanisms involved in improvement effect genistein.The animal model was established through unpredictable chronic mild stress. Nest building test splash were adapted evaluate effects on depressive symptoms mice. qRT-PCR western blot analysis used detect connexin 43 (Cx43)...
Tanshinone IIA is a diterpene extracted from Salvia miltiorrhiza, popular and safe herb medicine that has been widely used in China other Asian countries. Previous studies have demonstrated the pleiotropic effects of on many disease treatments via its antitoxicity, anti-inflammation, anti-oxidative stress, as well antifibrosis activities. However, effect acute kidney injury (AKI) not fully investigated. Here, we show for first time systemic administration can lead to improved function folic...
Our previous study demonstrated that the mammalian target of rapamycin complex 1 (mTORC1) pathway is activated in peritoneal fibrosis under high glucose condition. This aimed to investigate whether valsartan inhibits glucose-induced via decreasing activity mTORC1 pathway. We used dialysis solution a mouse model induce vivo and human mesothelial cells (HPMCs) stimulate extracellular matrix accumulation vitro. After injections containing 4.25% for four weeks, mice showed typical features...
It is important to explore novel therapeutic targets and develop an effective strategy for the treatment of anorexia nervosa. In this work, serum samples were analyzed using ultra-performance liquid chromatography coupled with quadrupole time-of flight mass spectrometry (UPLC/Q-TOF MS) chemometric analysis multivariate obtain metabolites their corresponding pathways. addition, knock-in knock-down key enzyme in vivo was performed verify reliability obtained metabolic pathway, which closely...
传统的颈部开放入路颌下腺切除会导致术后瘢痕，局部皮肤感觉异常或减退及皮肤粘连等问题。为解决这些问题让患者更多获益，越来越多的颈外入路内镜下颌下腺切除手术应运而生。四川省肿瘤医院头颈外科于2021年5月14日在国际上首次完成了经腋入路内镜下颌下腺切除术。患者术后康复快，美观效果满意，无并发症发生。患者术后5个月复查，颈部活动正常，未出现颈胸部皮肤感觉麻木或减退，腋窝切口隐蔽，疗效满意。经腋入路是一种美观、安全有效的颈外内镜下颌下腺切除手术入路。该入路适应证和临床应用价值还需进一步探索。.
Abstract Background Hydroxychloroquine (HCQ) is recommended for Chinese patients with immunoglobulin A nephropathy (IgAN). However, the relationship between HCQ blood concentration and therapeutic effect IgAN has not yet been defined. This study investigates optimal efficacious range of concentrations in IgAN. Methods Seventy-three biopsy-proven who were at risk progression included this study. Thirty-eight treated plus an optimized renin–angiotensin–aldosterone system inhibitor (RAASi),...
Peritoneal dialysis-associated peritonitis (PDAP) is a frequent complication of peritoneal dialysis. The guidelines from the International Society for Dialysis (ISPD) suggest administering teicoplanin through route to treat PDAP, but do not specify ideal concentration dialysis effluent (PDE). Patients meeting trial criteria PDAP in our hospital between July 2022 and December 2023 were enrolled. Data on PDE white blood cell count, neutrophil percentage, clinical symptoms, CRP, PCT gathered...
Objectives: To explore the causes of ineffective or short-term recurrence (within 3 months)of trigeminal neuralgia treated by percutaneous microballoon compression(PBC), and to examine reoperative strategies clincal outcomes modified PBC. Methods: The clinical data 21 patients with after PBC treatment (5.7% 369 patient received PBC) admitted Department Neurosurgery,Nanjing Drum Tower Hospital Clinical College Nanjing Medical University from June 2018 2020 were retrospectively analyzed.There...
Objective To evaluate the effect of continuous blood purification (CBP) on serum cytokines and apolipoprotein-2 (neutrophil gelatinase-associated lipocalin, NGAL) prognosis in patients with severe cardiac surgery-associated acute kidney injury (CSA-AKI). Methods A total 207 adult AKI following surgery were treated CBP between January 2005 December 2014. Exclusion criteria renal dysfunction before surgery, death within 24 hours after incomplete data. They divided into two groups:...
Problem-based learning is widely used in medical teaching.Case the basis of implementation PBL teaching.This paper discussed precautions case preparation.The should have authenticity and typicality,should be gradual with suspense.Designation combine knowledge students' learning.To improve teaching quality effect,case writing validation need to completed a professional team. Key words: Problem-based learning; Pediatrics; Case; Writing
Inborn errors of metabolism(IEM) has been frequently misdiagnosed or with delayed diagnosis,due to the fact that early symptoms have non-specific and too general.Promoting prenatal care counseling would helped discovery abnormal condition earlier,and thus take measures reduce incidence children birth defects.The education on neonatal hereditary metabolic disease,the promotion newborn screening,and timely review screening results by pediatricians should be emphasized synthetically,and will...
Objective To investigate the technique and effect of tunneled cuffed catheter as long-term hemodialysis access prevention its related complications.Methods Permcath dual lumen wag implanted in patients by standard Seldinger technique,that a guidewire wss inserted into deep central vein, following insertion through peel-away sheath.The complications were observed.Urea reduce rate(URR),the Kt/V,the normalized protein catabolic rate(nPCR)and time-averaged BUN concentration(TACurea)were measured...
Objective To observe the influence of calciurn-sensing receptor (CaSR) on intracellular calcium and to investigate mechanism CaSR induced injury cultured neonatal rat cardiomyocytes under anoxia/reoxygenation(A/R). Methods We incubated primarily ventricular in ischemia-mimetic solution for 60 min, re-incubated cell normal culture medium 30 min establish a model A/R. The were randomly divided into six groups: (1) control group; (2) A/ R group;(3) A/R + GdCl3 group:300/μmol/L GdCl3(a specific...
Objective To investigate clinical feature, therapy and prognosis of 63 (rhabdomyolysis, RM) patients. Methods Retrospective analysis was used for the patients who were from Nanjing Janurary 2010 to August 2016. Results Clinical history: pathogenic factors mainly contained eating lobster, excessive exercise, lipid-lowering drugs, minority induced by infection, cardiac defibrillation, alcohol, unexplained factors. Clinical features: most presented different degree muscle soreness...
Objective To explore the potential mechanisms of low density lipoprotein receptor (LDLr) in high glucose peritoneal dialysis solution (PDS)-induced fibrosis. Methods Human mesothelial cells (PMCs) were applied. In pre-experiment, human PMCs cultured with 1.5% PDS, 2.5% PDS and 4.25% for 6 h, 12 h 24 h. mannitol was used as osmotic pressure control. formal experiment, divided into control group(treated phosphate buffer saline) group (treated h). Morphological change observed by...
Objective To explore the value of integrated cardiopulmonary ultrasound in etiological diagnosis, disease monitoring, and prognosis evluation neonates with hypoxemia. Methods Forty-five hypoxemia admitted to Department Neonatology, Hangzhou First People's Hospital, Zhejiang University Medical College from January August 2018 were selected as a study group, 20 non-hypoxic who hospitalized during same period control group. All underwent ultrasonic examination. Echocardiography was used...
Abstract Objective: We aimed to analyze the clinical characteristics of peritoneal dialysis (PD) patients with different baseline transport and effect on prognosis PD patients. Methods: Patients who received for over 1 months in Nanjing Drum Tower Hospital between January 2006 December 2019 were included. They divided into four groups according dialysate/plasma creatinine (D/Pcr) value. The characteristics, changes transport, risk factors death technique failure analyzed. Results: A total...
Objective: To investigate the effects of calcium-sensing receptor (CaSR) on c-Jun N-terminal kinase (JNK) in myocardial injury induced by endotoxin. Methods: The endotoxic model neonatal rats was made intraperitoneal injection LPS(5 mg/kg). Neonatal Wistar were randomly divided into 6 groups: ①control group (saline group), ②endotoxin (LPS) group, ③LPS + CaSR agonist ④LPS inhibitor ⑤LPS JNK ⑥LPS group. morphology myocardium observed HE staining. content lactate dehydrogenase(LDH) serum...