The connection between peritoneal function and gut microbiota in fibrosis (PF) patients remains uncertain.

Background. Although clinical experience suggests that pneumonia may occur frequently in dialysis patients, its epidemiology group remains poorly defined.

ObjectiveTo investigate and analyse the quality of life (QoL) patients with chronic kidney disease (CKD) undergoing maintenance haemodialysis (MHD), explore influencing factors provide a basis for formulating corresponding intervention measures.MethodsA cross-sectional study was conducted on 120 CKD MHD in hospital between January 2020 June 2020. A general information questionnaire Kidney Disease Quality Life Short Form were used to collect data. The QoL scores calculated compared by t-test...

<b><i>Background:</i></b> Sodium, apart from volume, may have an independent effect on blood pressure (BP) regulation. <b><i>Methods:</i></b> Sixteen hypertensive hemodialysis patients were enrolled, who achieved their dry weight assessed by bioimpedance methods, with pre-dialysis plasma sodium levels slightly higher than the facility dialysate concentration 138 mmol/l. After a 1-month period of dialysis standard mmol/l, followed up for 4-month...

Background: Following the introduction of modified cellulosic and then synthetic membrane dialyzers, it was realized that dialyzer bio-incompatibility depends on composition. We designed a prospective, randomized, cohort study 6 months to determine several parameters biocompatibility in maintenance hemodialysis (MHD) patients treated with four different dialyzers. Methods: There were 60 MHD enrolled study. In baseline, low-flux dialyzer, polysulfone (PS) used all for at least 3 months. Then...

To investigate the current situation of palliative care needs and symptom burden in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD), to explore whether there are differences between younger older patients. This cross-sectional study was conducted centers two tertiary hospitals from November 2021 June 2022. Participants were selected by convenience sampling. Socio-demographics, clinical characteristics, Palliative Care Outcome Scale (POS), Dialysis...

Hyperglycemia that develops during pregnancy is a diagnostic criterion of gestational diabetes mellitus (GDM). Current studies have shown the expression miRNA-181d significantly enhanced in glomeruli type 2 diabetic. However, relationship between miR-181d and GDM has never been reported before.The serum samples were collected from patients with subjected to qRT-PCR verify potential altered expression. In an vitro model, was induced by high glucose treatment, inhibitor transfected into INS-1...

Objectives: To improve the mouse model of relief for unilateral ureteral obstruction (RUUO) and explore pathological process renal fibrosis after was relieved. Methods: C57BL/6 mice in group were randomly divided into RUUO group, improved UUO group. After leaving Unilateral Ureteral Obstruction (UUO) 3 days, released by reimplantation way + catheter observation 1d 3d 7d 14d Three days UUO, four groups. We detected volume, H&E, Masson staining, immunohistochemistry kidney pathology on seventh...

Evidence suggests that intracellular angiotensin II type 1 receptor (AT1) contributes to peritoneal fibrosis (PF) under high glucose (HG)-based dialysates. It is generally believed AT2 antagonisticly affects AT1 function. The aim of this study was explore whether activation beneficial for attenuating human mesothelial cell (HPMC) injury due HG. We treated a HPMC line with HG induce extracellular matrix (ECM) formation. increased and blocked using CGP42112A siRNA. Lipid deposition detected,...

Background: End-stage renal disease has been imposing a heavy economic burden on public health; however, few studies have performed the cost-effectiveness of dialysis modalities. We aim to estimate different modalities in China. Methods: Cost-effectiveness analyses were using Markov models based published data hemodialysis (HD) and peritoneal (PD) Sensitivity conducted identify key variables influencing results. Results: Over 10-year time horizon, base-case analysis indicated that PD-first...

Our previous study demonstrated that the mammalian target of rapamycin complex 1 (mTORC1) pathway is activated in peritoneal fibrosis under high glucose condition. This aimed to investigate whether valsartan inhibits glucose-induced via decreasing activity mTORC1 pathway. We used dialysis solution a mouse model induce vivo and human mesothelial cells (HPMCs) stimulate extracellular matrix accumulation vitro. After injections containing 4.25% for four weeks, mice showed typical features...

Peritoneal dialysis (PD)-related peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation in mesothelial cells (PMCs) during long-term use of high glucose (HG)-based dialysates. Activation the renin-angiotensin system (RAS) has been shown to be associated with PF. The aim this study was explore underlying mechanism RAS HG-induced We treated C57BL/6 mice and a human PMC line HG induce PF model stimulate ECM accumulation, respectively. activity blocked...

Abstract Background Peritoneal fibrosis is a common complication of peritoneal dialysis, which may lead to ultrafiltration failure and ultimately treatment discontinuation. LncRNAs participate in many biological processes during tumorigenesis. We investigated the role AK142426 fibrosis. Methods The level dialysis (PD) fluid was detected by quantitative real‐time‐PCR assay. M2 macrophage distribution determined flow cytometry. inflammatory cytokines TNF‐ α TGF‐ β 1 were measured ELISA direct...

Objective: A retrospective study was conducted to explore the immune-inflammatory responses in sudden sensorineural hearing Loss (SSNHL) patients with different audiogram shapes. Methods: One hundred and ten inpatients SSNHL were assigned 4 subgroups according shape treated systemic methylprednisolone. The numbers of white blood cells, neutrophils, lymphocytes, platelets, monocytes counted. neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR)...

Catheter malfunction is the main reason for early peritoneal dialysis (PD) technique failure. This study aimed to evaluate effect of a new surgery with catheter fixation lower abdominal wall combined straight upward tunnel and low implant position in reducing malfunction.Patients end stage renal disease who received PD our centre from January 2013 December 2015 were involved this study. They randomly divided into three groups according surgical technique: traditional open group, modified...

Blood pressure variability is an independent risk factor for mortality and cardiovascular events in hemodialysis patients. Dialysate sodium concentration may not only have effects on blood but also variability. We investigated whether dialysate lowering could decrease home Forty-three patients at their dry weight assessed by bioimpedance methods with pre-dialysis serum >136 mmol/L were recruited. Firstly, underwent a 1-month standard dialysis of 138 mmol/L, then the was decreased to 136 8...