Fang Shen

ORCID: 0000-0001-6737-6502
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About
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Research Areas
  • Endometrial and Cervical Cancer Treatments
  • Pregnancy and preeclampsia studies
  • Glioma Diagnosis and Treatment
  • Spine and Intervertebral Disc Pathology
  • Birth, Development, and Health
  • Spinal Fractures and Fixation Techniques
  • Ovarian cancer diagnosis and treatment
  • Spinal Hematomas and Complications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Reproductive System and Pregnancy
  • Meningioma and schwannoma management
  • Gestational Diabetes Research and Management
  • Neurosurgical Procedures and Complications
  • Cancer Mechanisms and Therapy
  • Cervical Cancer and HPV Research
  • Gynecological conditions and treatments
  • Genital Health and Disease
  • Neurofibromatosis and Schwannoma Cases
  • Attention Deficit Hyperactivity Disorder
  • Ferroptosis and cancer prognosis
  • Thyroid Cancer Diagnosis and Treatment
  • Head and Neck Surgical Oncology
  • Cancer Risks and Factors
  • Spinal Dysraphism and Malformations
  • Cancer Immunotherapy and Biomarkers

Dali University
2022-2025

Second Affiliated Hospital of Zhejiang University
2008-2025

Obstetrics and Gynecology Hospital of Fudan University
2014-2024

Third People's Hospital of Huzhou
2024

Sichuan University
2024

Nanjing Medical University
2024

Central South University
2024

Chongqing Medical University
2024

Sir Run Run Shaw Hospital
2024

Zhejiang University
2005-2024

Purvalanol A is a highly selective inhibitor of Cdc2 [also known as cyclin-dependent kinase 1 (CDK1)]. Taxol an anti-tumor chemotherapeutic drug which widely used clinically. In this study, the CDK1 inhibitor, purvalanol was applied to explore relevance signaling and taxol sensitivity through analyses, such cellular proliferation apoptosis assays, ELISA, western blot analysis immunoprecipitation. We demonstrated that effectively enhanced taxol-induced NCI-H1299 cells, well its inhibitory...

10.3892/ijmm.2017.2989 article EN International Journal of Molecular Medicine 2017-05-15

// Fang Shen 1 , Yifei Gao Jingxin Ding Qi Chen 1, 2 The Hospital of Obstetrics & Gynaecology, Fudan University, China Department University Auckland, New Zealand Correspondence to: Chen, email: q.chen@auckland.ac.nz Ding, djxdd@sina.com Keywords: endometrial cancer, type and 2, ER, PR, menopause Received: August 23, 2016      Accepted: November 15, Published: 19, 2016 ABSTRACT Endometrial cancer is a major in women traditionally divided into 2. It well known...

10.18632/oncotarget.13471 article EN Oncotarget 2016-11-19

STUDY QUESTIONWhat is the difference in vaginal-length gain and resumption of menstruation following cervicovaginal reconstruction using split-thickness skin (STS) graft versus small intestinal submucosa (SIS) for patients with congenital vaginal cervical aplasia?

10.1093/humrep/dew230 article EN Human Reproduction 2016-09-22

The present study was conducted to determine the relationship between neurotic personality traits and symptoms of post-traumatic stress disorder (PTSD) in breast cancer patients, with mediation self-efficacy negative coping. A cross-sectional design used. total 328 patients admitted two tertiary hospitals Dali, China, from July 2023 January 2024 were included. Participants completed General Information Questionnaire, PTSD Inventory-Civilian Version, Social Support Rating Scale, Brief Coping...

10.1186/s40359-025-02496-4 article EN cc-by-nc-nd BMC Psychology 2025-03-21

OBJECT Posterior midline laminectomy or hemilaminectomy has been successfully applied as the standard microsurgical technique for treatment of spinal intradural pathologies. However, associated risks postoperative instability increase need subsequent fusion surgery to prevent potential long-term deformity. Continuous efforts have made minimize injuries surrounding tissue resulting from surgical manipulations. The authors report here their experiences with a novel minimally invasive approach,...

10.3171/2015.5.focus15182 article EN Neurosurgical FOCUS 2015-08-01

Abstract The estrogen (ER) or progesterone receptors (PR) is positively associated with better clinical outcomes in ovarian cancer. Whether metastasis recurrence of cancer correlated this association has not been investigated. Data on 894 women epithelial were collected and the between ER PR positivity peritoneal lymph node metastases was analysed. higher high-grade, low-grade serous endometrioid carcinoma, but lower mucinous clear-cell carcinoma. Significantly seen carcinoma high-grade...

10.1038/s41598-017-17265-6 article EN cc-by Scientific Reports 2017-11-29

RNA-binding protein fox-1 homolog 1 (Rbfox-1), an in neurons, is thought to be associated with many neurological diseases. To date, the mechanism on which Rbfox-1 worsens secondary cell death ICH remains poorly understood. In this study, we aimed explore role of intracerebral hemorrhage (ICH)-induced brain injury (SBI) and identify its underlying mechanisms. We found that expression neurons was significantly increased after ICH, accompanied by increases binding Ca 2+ /calmodulin-dependent...

10.1177/0271678x20916860 article EN Journal of Cerebral Blood Flow & Metabolism 2020-04-04

Breast cancer is the most common in women worldwide. Studies have suggested that Ras-related protein 25 (Rab25), a member of Rab small GTPase family, involved pathogenesis breast cancer. In this study, we investigated whether expression Rab25 correlated with lymphatic metastasis and was positively oestrogen receptor (ER) progesterone (PR) tissues from 42 invasive ductal patients or without were collected levels mRNA measured by quantitative real-time PCR immunohistochemistry, respectively....

10.1007/s13277-012-0412-5 article EN Tumor Biology 2012-05-29

Ovarian cancer is the major gynaecologic malignancy and leading cause of death in gynaecological cancer. Heat shock proteins (HSPs) are highly expressed many malignant cancers involved metastasis including ovarian The early detection peritoneal metastases epithelial may be more important clinical care. HSP27, a small heat protein, correlated with tissues. In this study, we investigated whether levels total HSP27 were detectable serum it could predictive biomarker for Serum samples from 48...

10.1007/s13277-013-1139-7 article EN Tumor Biology 2013-09-04

The incidence of ovarian cancer depends on the ethnicity and geographical area. Menopausal status is a well-known risk factor for most cases occur after menopause in Caucasians. However, it less clear how or age at diagnosis associated with including its subtypes Chinese women. Data 1,283 women primary malignant borderline diagnosis, histology from largest women's hospital China was analysed. median 53, 44 23 years epithelial sex-cord tumors germ cell respectively. 58% cancers were diagnosed...

10.18632/oncotarget.20384 article EN Oncotarget 2017-08-22

Recent studies have indicated the possibility that genistein may improve depression via regulating expression of miR221/222. This study is to explore whether could by altering miR-221/222 levels and investigate possible mechanisms involved in improvement effect genistein.The animal model was established through unpredictable chronic mild stress. Nest building test splash were adapted evaluate effects on depressive symptoms mice. qRT-PCR western blot analysis used detect connexin 43 (Cx43)...

10.30773/pi.2018.06.29 article EN Psychiatry Investigation 2018-09-12
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