A5103213954- Trigeminal Neuralgia and Treatments
- Facial Nerve Paralysis Treatment and Research
- Botulinum Toxin and Related Neurological Disorders
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Reconstructive Facial Surgery Techniques
- Spinal Dysraphism and Malformations
- Peripheral Nerve Disorders
- Neurogenesis and neuroplasticity mechanisms
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Ear Surgery and Otitis Media
- Cancer Cells and Metastasis
- Nerve injury and regeneration
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Pain Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Neurological disorders and treatments
- RNA Research and Splicing
- Mesenchymal stem cell research
- Orthopedic Surgery and Rehabilitation
- Spinal Fractures and Fixation Techniques
- Elbow and Forearm Trauma Treatment
Zhuzhou Central Hospital
2022-2024
Shanghai Jiao Tong University
2012-2022
XinHua Hospital
2012-2021
Fundación Juan March
2017
First Affiliated Hospital Zhejiang University
2007-2011
Zhejiang University
2007-2008
Zhejiang Chinese Medical University
2008
Abstract Cancer stem cells have been isolated from human gliomas and many other parenchymal tumors. It was previously assumed that established malignant cell lines also contain a rare subpopulation of cells. This study designed to investigate the fraction cancer in C6 glioma line using clonal population analyses, rather than isolating methods, which are based on specific markers. Interestingly, serum-containing medium, each 67 single plated per miniwell able generate clone subclones,...
Glioblastoma multiforme ( GBM ) is one of the most malignant human intracranial tumors. Temozolomide TMZ primary alkylating agent for patients. However, many patients are resistant to . Therefore, with urgently need more effective therapeutic options. 20(S)‐ginsenoside‐Rg3 (20(S)‐Rg3) a natural chemical anti‐tumor effects, but at present there little understanding its functional mechanism. Several research reports have demonstrated that O 6 ‐methylguanine DNA ‐methyltransferase MGMT repairs...
Background: Glioblastoma (GBM) represents the most aggressive glioma with high invasive potential. Recent studies proved involvement of epithelial-mesenchymal transition (EMT) process in increasing malignancy and invasiveness GBM. LncRNAs have been verified to play pivotal roles human disease including However, molecular mechanisms lncRNA-mediated EMT GBM remain largely unknown. LINC-PINT, a LncRNA which has never studied before, was predicted be negatively associated This study aimed...
Abstract NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) is a subunit of Complex I the mitochondrial respiratory chain, which important in metabolic reprogramming and oxidative stress multiple cancers. However, biological role molecular regulation NDUFA4L2 glioblastoma (GBM) are poorly understood. Here, we found that was significantly upregulated GBM; elevated levels were correlated with reduced patient survival. Gene knockdown inhibited tumor cell proliferation...
Despite the vascular compression of seventh cranial nerve has been verified by microvascular decompression surgery as cause hemifacial spasm (HFS), mechanism disease is still unknown. We believe that autonomic nervous system in adventitia offending artery may contribute to HFS. To prove our hypothesis, we performed an experiment SD rats.Moller's HFS model was adopted and abnormal muscle response (AMR) wave electrophysiologically monitored. With randomization, some rats underwent exclusion or...
CXC chemokine receptor 4 (CXCR4) is a cell surface molecule expressed in distinct subset of glioma cells with enhanced tumorigenicity, and it related to many important biological activities the tumor. We supposed that this might be "marker" for stem cells. This hypothesis was tested both vitro vivo. The CXCR4+ CXCR4- subsets were sorted from three human malignant specimens. They capability colony formation soft agar, generation tumorosphere, self-renewal, multipotent differentiation vitro,...
MutS homolog 6 (MSH6) is one of the mismatch repair proteins and encoded by MSH6 gene, which located on chromosome 2 23,806 bp in length, including 10 exons 83 untranslated regions. The protein consists 1,358 amino acid residues forms a heterodimer with another protein, MSH2. MSH2-MSH6 heterodimeric complex able to recognize base-base substitution single-base insertion/deletion mismatches. Germline mutations lead high susceptibility glioma, as well number benign or malignant tumors other...
Abstract In various malignant tumors, NF-kappa B interacting long noncoding RNA (NKILA) displays antitumor activity by inhibiting the pathway. However, role of NKILA in gliomas remains unclear. Surprisingly, this study showed that is significantly upregulated gliomas, and increased levels were correlated with a decrease patient survival time. expression level hypoxia-inducible factor-1α, hypoxia pathway gliomas. Furthermore, we demonstrated enhances Warburg effect angiogenesis both vitro...
Objective: O6-methylguanine (O6-meG) DNA-methyltransferase (MGMT) is a main regulator of temozolomide (TMZ) resistance in glioblastomas. Some MGMT inhibitors have been studied clinical trials but with very little success, because their inhibiting effects were not tumor-selective, and often cause severe toxicity normal tissues the presence TMZ. The goal this study to explore whether Epigallocatechin gallate (EGCG), natural small molecule, could preferentially modulate glioblastoma...
<b>Background</b> In 1992, Dellon reported the first use of peripheral nerve decompression surgery in treatment limb diabetic neuropathy (DPN). However, efficacy this procedure is still under debate. clinic study, we analyzed therapeutic effect microsurgical for DPN patients, using both clinical evaluation and electrophysiological testing. <b>Patients Methods</b> 560 patients with , surgical as described by was performed. Before 18 months after surgery, Toronto Clinical Scoring System,...
The aim of this study is to introduce zone exploration the trigeminal nerve and decompression techniques for different types vasculars.The was sectioned into 5 zones. Zone 1, 2, 3, 4 located at rostral, caudal, ventral, dorsal part root entry (REZ) respectively, distal root. This contained 86 patients with neuralgia underwent microvascular decompression. Every exposed through preoperative imaging. During operation, offending vessels were explored from 1 5, used vessels.Through exploration,...