A5026578814- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- Streptococcal Infections and Treatments
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Kawasaki Disease and Coronary Complications
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Circular RNAs in diseases
- Nerve injury and regeneration
- Facial Nerve Paralysis Treatment and Research
- RNA Research and Splicing
- Aquatic life and conservation
- Congenital Anomalies and Fetal Surgery
- Mitochondrial Function and Pathology
- Reconstructive Facial Surgery Techniques
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- Ginseng Biological Effects and Applications
- Spinal Dysraphism and Malformations
- Teratomas and Epidermoid Cysts
- RNA modifications and cancer
- Echinoderm biology and ecology
- Neonatal Health and Biochemistry
Chinese Academy of Sciences
2024-2025
Institute of Oceanology
2024-2025
Qingdao National Laboratory for Marine Science and Technology
2024-2025
University of Chinese Academy of Sciences
2024-2025
College of Marin
2024-2025
XinHua Hospital
2018-2021
Shanghai Jiao Tong University
2018-2021
Glioblastoma multiforme ( GBM ) is one of the most malignant human intracranial tumors. Temozolomide TMZ primary alkylating agent for patients. However, many patients are resistant to . Therefore, with urgently need more effective therapeutic options. 20(S)‐ginsenoside‐Rg3 (20(S)‐Rg3) a natural chemical anti‐tumor effects, but at present there little understanding its functional mechanism. Several research reports have demonstrated that O 6 ‐methylguanine DNA ‐methyltransferase MGMT repairs...
Background: Glioblastoma (GBM) represents the most aggressive glioma with high invasive potential. Recent studies proved involvement of epithelial-mesenchymal transition (EMT) process in increasing malignancy and invasiveness GBM. LncRNAs have been verified to play pivotal roles human disease including However, molecular mechanisms lncRNA-mediated EMT GBM remain largely unknown. LINC-PINT, a LncRNA which has never studied before, was predicted be negatively associated This study aimed...
Abstract NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) is a subunit of Complex I the mitochondrial respiratory chain, which important in metabolic reprogramming and oxidative stress multiple cancers. However, biological role molecular regulation NDUFA4L2 glioblastoma (GBM) are poorly understood. Here, we found that was significantly upregulated GBM; elevated levels were correlated with reduced patient survival. Gene knockdown inhibited tumor cell proliferation...
Type III secretion system (T3SS) is a virulence apparatus existing in many bacterial pathogens. Structurally, T3SS consists of the base, needle, tip, and translocon. The NLRC4 inflammasome major receptor for needle basal rod proteins. Whether other components are recognized by unclear. In this study, using Edwardsiella tarda as model intracellular pathogen, we examined T3SS−inflammasome interaction its effect on cell death. E. induced pyroptosis manner that required translocon host proteins...
Type III secretion system (T3SS) is a virulence apparatus existing in many bacterial pathogens. Structurally, T3SS consists of the base, needle, tip, and translocon. The NLRC4 inflammasome major receptor for needle basal rod proteins. Whether other components are recognized by unclear. In this study, using Edwardsiella tarda as model intracellular pathogen, we examined T3SS−inflammasome interaction its effect on cell death. E. induced pyroptosis manner that required translocon host proteins...
Abstract In various malignant tumors, NF-kappa B interacting long noncoding RNA (NKILA) displays antitumor activity by inhibiting the pathway. However, role of NKILA in gliomas remains unclear. Surprisingly, this study showed that is significantly upregulated gliomas, and increased levels were correlated with a decrease patient survival time. expression level hypoxia-inducible factor-1α, hypoxia pathway gliomas. Furthermore, we demonstrated enhances Warburg effect angiogenesis both vitro...
Caspase (CASP) is a protease family that plays vital role in apoptosis, development, and immune response. Herein, we reported the identification characterization of two CASPs, AjCASPX1 AjCASPX2, from sea cucumber Apostichopus japonicus, an important aquaculture species. AjCASPX1/2 share similar domain organizations with vertebrate initiator caspases CASP2/9, including CARD p20/p10 subunits conserved functional motifs. However, compared human possess unique structural features linker region...
Abstract Type III secretion system (T3SS) is a virulence apparatus existing in many bacterial pathogens. Structurally, T3SS consists of the base, needle, tip, and translocon. The NLRC4 inflammasome major receptor for needle basal rod proteins. Whether other components are recognized by unclear. In this study, using Edwardsiella tarda as model intracellular pathogen, we examined T3SS−inflammasome interaction its effect on cell death. E. induced pyroptosis manner that required translocon host...
Type III secretion system (T3SS) is a virulence apparatus existing in many bacterial pathogens. Structurally, T3SS consists of the base, needle, tip, and translocon. The NLRC4 inflammasome major receptor for needle basal rod proteins. Whether other components are recognized by unclear. In this study, using Edwardsiella tarda as model intracellular pathogen, we examined T3SS−inflammasome interaction its effect on cell death. E. induced pyroptosis manner that required translocon host proteins...
Type III secretion system (T3SS) is a virulence apparatus existing in many bacterial pathogens. Structurally, T3SS consists of the base, needle, tip, and translocon. The NLRC4 inflammasome major receptor for needle basal rod proteins. Whether other components are recognized by unclear. In this study, using Edwardsiella tarda as model intracellular pathogen, we examined T3SS−inflammasome interaction its effect on cell death. E. induced pyroptosis manner that required translocon host proteins...
Facial nerve injury often results in facial paralysis, which seriously affects the patients both aesthetically and functionally. reinnervation methods, including direct anastomosis, graft, transposition, cross-facial combined surgeries, have recently become a hot topic with many new procedures being explored. This study summarizes relevant literatures discusses scope of application, advantages, disadvantages different methods. The treatment options or surgeries for should be individualized...