A5090777984- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Soft Robotics and Applications
- Advanced oxidation water treatment
- Advanced Surface Polishing Techniques
- Neurosurgical Procedures and Complications
- Polysaccharides and Plant Cell Walls
- Neuroinflammation and Neurodegeneration Mechanisms
- Scoliosis diagnosis and treatment
- Spinal Dysraphism and Malformations
- Case Reports on Hematomas
- Advanced Measurement and Metrology Techniques
- Musculoskeletal pain and rehabilitation
- Nerve injury and regeneration
- Medical Imaging and Analysis
- Advanced machining processes and optimization
- Surgical Simulation and Training
- Radiomics and Machine Learning in Medical Imaging
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Optical Systems and Laser Technology
Second Affiliated Hospital of Zhejiang University
2016-2025
First Affiliated Hospital of Zhengzhou University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Wuyi University
2021-2024
Southern Medical University
2016-2024
Nanfang Hospital
2016-2024
Zhejiang University
2015-2023
Zhejiang Normal University
2022
Hainan University
2020-2021
Institute of Hematology & Blood Diseases Hospital
2020
This study is aimed at investigating the changes in relevant pathways and differential expression of related gene after ischemic stroke (IS) single-cell level using multiple weighted coexpression network analysis (WGCNA) analysis.The transcriptome datasets IS samples RNA sequencing (scRNA-seq) profiles cerebrovascular tissues were obtained by searching Gene Expression Omnibus (GEO) database. First, pathway scoring was calculated via set variation (GSVA) imported into WGCNA to acquire key...
Age-related long-term disability is attracting increasing attention due to the growing ageing population worldwide. However, current understanding of senescent spinal cord remains insufficient. Bulk RNA sequencing reveals that 526 genes are upregulated and 300 downregulated in cords. Pathway enrichment analysis differentially expressed shows senescence cords related phagosome function, neuroinflammation, ferroptosis, necroptosis. Prediction upstream transcription factors interactome identify...
Neuroinflammation is regarded as a vital pathological process in spinal cord injury (SCI), which removes damaged tissue, secretes cytokines, and facilitates regeneration. Repopulation of microglia has been shown to favor recovery from SCI. However, the origin regulatory factors repopulation after SCI remain unknown. Here, we used single-cell RNA sequencing portray dynamic transcriptional landscape immune cells during early late phases mice. B migDCs, located meninges under physiological...
OBJECT Posterior midline laminectomy or hemilaminectomy has been successfully applied as the standard microsurgical technique for treatment of spinal intradural pathologies. However, associated risks postoperative instability increase need subsequent fusion surgery to prevent potential long-term deformity. Continuous efforts have made minimize injuries surrounding tissue resulting from surgical manipulations. The authors report here their experiences with a novel minimally invasive approach,...
Spinal cord injury (SCI) causes nearly all patients to suffer from protracted disabilities. An emerging therapeutic strategy involving the recruitment of endogenous neural stem cells (NSCs) has been developed. However, NSCs in adult spinal differentiate into mostly astrocytes after traumatic injury, forming glial scars, which is a major cause regeneration failure SCI. Thus, understanding factors drive activation and differentiation SCI critical for developing drugs.The infiltration, state,...
Abstract Handheld robots offer accessible solutions with a short learning curve to enhance operator capabilities. However, their controllable degree-of-freedoms are limited due scarce space for actuators. Inspired by muscle movements stimulated nerves, we report handheld time-share driven robot. It comprises several motion modules, all powered single motor. Shape memory alloy (SMA) wires, acting as “nerves”, connect enabling the selection of activated module. The robot contains 202-gram...
This study aimed to assess the association between obesity, sarcopenia, and sarcopenic obesity with hypertension explore potential mediation of inflammation indicators insulin resistance. Data from UK Biobank, a large-scale prospective cohort, were utilized. Obesity was defined using percentage fat mass, while sarcopenia as low muscle mass strength. The primary outcome assessed new-onset within 5-year follow-up period. analysis examined Cox regression model. A total 183,091 participants...
Existing orthopaedic robotic systems are almost restricted to provide guidance for trajectory direction. In the present study, a novel spinal system with automatic drilling power was introduced. The aim of this study is evaluate feasibility and safety in pedicle screw insertion posterior lumbar interbody fusion assisted by system.A randomised controlled trial conducted 17 participants who were required process. Seven (3 M/4 F) randomly assigned robot-assisted group (RA group), other ten (4...
The critical role of vascular health on brain function has received much attention in recent years. At the single-cell level, studies developmental processes cerebral growth are still relatively few. Techniques for constructing gene regulatory networks (GRNs) based transcriptome expression data have made significant progress Herein, we constructed a transcriptional network mouse cerebrovascular cells.The RNA-seq dataset vessels was downloaded from GEO (GSE98816). This cell clustering...
Abstract Objectives To investigate the value of extracellular volume (ECV) derived from portal-venous phase (PVP) in predicting prognosis locally advanced pancreatic cancer (LAPC) patients receiving intraoperative radiotherapy (IORT) with initial stable disease (SD) and to construct a risk-scoring system based on ECV clinical-radiological features. Materials methods One hundred three LAPC who received IORT demonstrating SD were enrolled underwent multiphasic contrast-enhanced CT (CECT)...