A5032499409- Autophagy in Disease and Therapy
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Toxoplasma gondii Research Studies
- Child Nutrition and Water Access
- Neurogenesis and neuroplasticity mechanisms
- Infant Nutrition and Health
- Cerebrospinal fluid and hydrocephalus
- Neurogenetic and Muscular Disorders Research
- Neonatal Respiratory Health Research
- Ubiquitin and proteasome pathways
- Nerve injury and regeneration
- Spinal Dysraphism and Malformations
- Gut microbiota and health
- Advanced battery technologies research
- Calcium signaling and nucleotide metabolism
Zhejiang University
2022-2025
Sir Run Run Shaw Hospital
2023-2025
Fujian Medical University
2024
Traumatic spinal cord injury (SCI) causes severe central nervous system damage. M2 macrophages within the lesion are crucial for SCI recovery. Our previous research revealed that transfected with magnetotactic bacteria–derived Mms6 gene can resist ferroptosis and enhance To address limitations of macrophage transplantation, we developed lipid nanoparticles (LNPs) encapsulating mRNA targeting ( mRNA-PS/LNPs). The efficiency therapeutic effect these LNPs in mice were evaluated. Intravenous...
Abstract Recent studies have shown that nucleophagy can mitigate DNA damage by selectively degrading nuclear components protruding from the nucleus. However, little is known about role of in neurons after spinal cord injury (SCI). Western blot analysis and immunofluorescence were performed to evaluate leakage SCI vivo NSC34 expression primary cultured with oxygen–glucose deprivation (OGD) vitro, as well interaction colocalization autophagy protein LC3 lamina Lamin B1. The effect UBC9, a...
Spinal cord injury (SCI) causes nearly all patients to suffer from protracted disabilities. An emerging therapeutic strategy involving the recruitment of endogenous neural stem cells (NSCs) has been developed. However, NSCs in adult spinal differentiate into mostly astrocytes after traumatic injury, forming glial scars, which is a major cause regeneration failure SCI. Thus, understanding factors drive activation and differentiation SCI critical for developing drugs.The infiltration, state,...
Abstract Magnetotactic bacteria are microaerobic microorganisms that take up iron from solution and crystallize magnetite nanoparticles called magnetosomes, enclosed by membrane intracellularly mainly formed the magnetosome membrane‐specific 6 ( Mms6 ) gene. M2 macrophages transfected magnetotactic bacteria‐derived gene to form magnetic bio‐nanoparticles. Under myelin debris‐rich hypoxic stress in spinal cord injury (SCI) microenvironment, ‐transfected can antagonize ferroptosis. Meanwhile,...