A5058439392- Antifungal resistance and susceptibility
- Mechanical Circulatory Support Devices
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetic Foot Ulcer Assessment and Management
- Infective Endocarditis Diagnosis and Management
- Tuberculosis Research and Epidemiology
- Orthopedic Infections and Treatments
- Antibiotic Use and Resistance
- Wound Healing and Treatments
- Interpreting and Communication in Healthcare
- Respiratory Support and Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac, Anesthesia and Surgical Outcomes
- Patient-Provider Communication in Healthcare
- Streptococcal Infections and Treatments
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Physiological and biochemical adaptations
- Peptidase Inhibition and Analysis
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
Michigan Medicine
2020-2025
University of Michigan
2018-2025
Cleveland Clinic Florida
2024
A. Alfred Taubman Health Care Center
2023
Hainan University
2021
Shaoxing People's Hospital
2021
VA Ann Arbor Healthcare System
2020
Howard Hughes Medical Institute
1993-2017
University of California, San Francisco
2017
Michigan State University
2014
Abstract Background Severe coronavirus disease 2019 (COVID-19) can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent cytokine release syndrome for which IL-6 blockade is an approved treatment. Methods We assessed effectiveness safety of tocilizumab a single-center cohort patients COVID-19 requiring mechanical ventilation. The primary endpoint was survival probability postintubation; secondary analyses included ordinal illness severity...
ABSTRACT Background Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers. This presentation is consistent cytokine release syndrome chimeric antigen receptor T cell therapy, for which IL-6 blockade approved treatment. Methods We assessed effectiveness safety of tocilizumab a single-center cohort patients requiring mechanical ventilation. The primary endpoint was survival probability post-intubation; secondary analyses included an...
Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality evidence.To construct a clinical guideline for pyogenic osteomyelitis management, with new standard evidence resolve the gap evidence, through use novel open access approach utilizing social media tools.This consensus statement systematic review study used from WikiGuidelines Group, an collaborative research project, osteomyelitis. In June 2021 February 2022, authors...
This JAMA Insights Clinical Update discusses current recommendations regarding prevention of Pneumocystis pneumonia in patients who are immunocompromised.
Abstract Background While echocardiography and cardiac positron emission tomography (PET) can aid in the diagnosis of prosthetic valve endocarditis (PVE), post-operative changes lead to false-positive imaging findings. We report a case patient with an aortic prosthesis remnant BioGlue deposits mimicking para-valvular abscess on setting suspected PVE. Case summary A 67-year-old man presented 2 days fever, chills, altered mentation. He had history two prior root replacements—19 4 years his...
Background: Infections following durable left ventricular assist device (dLVAD) implantation are common and associated with increased morbidity mortality. Despite documented interhospital variability, few studies have identified strategies to mitigate their occurrence. This national study uses a multistage mixed methods design develop customizable deployable toolkit of expert-guided recommendations reduce infections post-dLVAD. Methods: Representatives from low, medium, high-performance...
While the signals and complexes that coordinate heartbeat are well established, how heart maintains its electromechanical rhythm over a lifetime remains an open question with significant implications to human health. Reasoning this homeostatic challenge confronts all pulsatile organs, we developed high resolution imaging analysis toolset for measuring cardiac function in intact, unanesthetized Drosophila melanogaster. We demonstrate that, as humans, normal aging primarily manifests defects...
The multisubunit transcription factor TFIID is an essential component of the RNA polymerase II initiation apparatus. Recent studies suggest that subunits, or TAFs associated with TATA-binding protein (TBP), play a critical role in modulating transcriptional activation by sequence-specific DNA-binding factors. Thus far, six largest Drosophila have been cloned and partially characterized. Here, we report molecular cloning, expression, subunit interaction specificities two small mass TAFs. Both...
This JAMA Patient Page describes syphilis, its signs and symptoms, diagnosis, treatment.
Abstract Diabetic foot ulcers commonly precede diabetic osteomyelitis (DFO) and once the latter occurs, surgical management is often performed. The presence of an independent risk factor for development re‐ulceration. We investigated relationship between causative organisms in 1‐year outcomes (re‐ulceration, amputation, death) following observational cohort 223 patients. Univariate multivariate analyses were performed available demographic, clinical, laboratory data. In addition, random...
The care delivered to patients with cardiovascular disease involves coordination among a multitude of clinical team members spanning diverse inpatient and outpatient settings. majority quality improvement interventions in have been developed based on quantitative evidence, which neither fully accounts for multilevel determinants (eg, patient, clinician, institution) nor contextualization from key informants. rigor effectiveness these would be enhanced by mixed-methods studies whose strengths...
This JAMA Patient Page describes the viral infection dengue and its signs symptoms, diagnosis, treatment, prevention measures.
The diagnosis of invasive pulmonary aspergillosis (IPA) remains challenging. We evaluated the performance characteristics a newly formatted Aspergillus lateral flow test, AspLFD, in bronchoalveolar lavage (BAL) fluid from patients with classic risk factors for IPA.Prospectively banked BAL samples 14 proven or probable IPA defined by EORTC/MSG criteria and 28 age-matched high-risk without were tested AspLFD according to manufacturer's directions. Results read two independent observers, test...
We describe the case of a patient with pancreatitis followed by intra-abdominal infection in which source control was not achieved. Antimicrobial therapy led to emergence resistance multiple organisms through population dynamics processes. While initial insult due infection, subsequent infections resistant contributed poor outcome for patient. Though evolution known risk, it difficult predict next organism that would arise setting antibiotic pressure and its profile. This illustrates...
In a cohort of patients with diabetic foot osteomyelitis who were recommended to undergo below-knee amputation, those deferred amputation and chose medical therapy more likely die during the follow-up time compared proceeded amputation.
We evaluated the performance of (1,3)-β-d-glucan (BDG) assay on bronchoalveolar lavage fluid (BALF) as a possible aid to diagnosis Pneumocystis jirovecii pneumonia. BALF samples from 18 patients with well-characterized proven, probable, and pneumonia well-matched controls were tested. found that best test was observed cut-off value 128 pg/mL; receiver operating characteristic/area under curve (ROC/AUC) 0.70 (95% CI 0.52-0.87). Sensitivity specificity 78% 56%, respectively; positive...